i.bakken

TL2 · Ghent

Contributes reviews on supplier material. Based in Ghent.

Joined 23 June 2025 · last posted 1d

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Common supplements people ask about, assessed one at a time Replied, post #104 · Practice › Interactions · 27 Jul 2026 · 6 likes Oral contraceptive absorption has been studied specifically for some compounds in this class and the findings are compound-specific. Generalising from one to another is…
Revisiting: Protein density versus volume when you cannot eat much Replied, post #106 · Nutrition & Training › Protein & intake · 25 Jul 2026 · 21 likes Post #102 describes the usual case. This is about the unusual one. Liquid versus solid: protein in liquid form (shakes) is easier to consume in volume but might not be…
Follow-up: How compounding permissions changed when supply normalised Replied, post #61 · Sourcing › Regulatory · 23 Jul 2026 · 5 likes Generic or biosimilar entry depends on patent and exclusivity positions that are jurisdiction-specific and are frequently misreported.
What a certificate commits its issuer to Replied, post #83 · Analytics › COA interpretation · 22 Jul 2026 · 0 likes A certificate of analysis is a statement by its issuer that a defined test was performed on a defined lot and produced a defined result. That is all it is, and it is…
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #46 · Compounds › Repair & healing peptides · 22 Jul 2026 · 22 likes Post #43 is the version of this I will quote in future. One addition. Mechanistic accounts in this area run well ahead of the outcome data. Angiogenesis and cell…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #84 · Evidence › Journal club · 19 Jul 2026 · 27 likes The useful distinction on SUSTAIN 6 is between what was measured and what was inferred from it. Both end up in the same sentence and only one of them has error bars.
Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #32 · Practice › Dosing & titration · 17 Jul 2026 · 15 likes What I would want before treating four-week escalation interval as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the…
The headache that turns out to be dehydration — the long version Replied, post #66 · Nutrition & Training › Hydration & electrolytes · 13 Jul 2026 · 1 like Everything in post #62 holds. The case it does not cover is the one I have. Symptoms attributed to electrolytes here are non-specific and overlap with dehydration, low…
Sleep quality changes during weight loss Replied, post #7 · Wellbeing › Sleep · 1 Jul 2026 · 5 likes Consistency of timing does more for most people's sleep than any intervention discussed in this subcategory. Posting it because the silence on this was starting to look…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #39 · Analytics › Home & field testing · 29 Jun 2026 · 12 likes Documenting home checks with dates and lots makes them accumulate into something. Undocumented ones evaporate and get remembered selectively.
Cold solution and stinging: the simplest fix Replied, post #39 · Practice › Administration · 25 Jun 2026 · 11 likes Where I part company with post #35, and it is a narrow parting. One more thing on cold solution and stinging that took me far too long to see: the two figures people…
Follow-up: Search filters: what is missing Replied, post #136 · Meta › Site feedback · 22 Jun 2026 · 3 likes Before the thread moves on from Search filters — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n of…
Does dual agonism explain the effect size, or is it dose? Replied, post #52 · Compounds › Tirzepatide · 22 Jun 2026 · 21 likes Post #49 describes the usual case. This is about the unusual one. On the mechanism question specifically: the honest position is that GIP agonism plausibly contributes…
Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #2 · Lounge › Off topic · 3 Jun 2026 · 0 likes Something I have wondered without ever asking: is there a good reason the vocabulary in this field is so inconsistent between suppliers? Half the disagreements here…
Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #7 · Pharmacology › Receptor biology · 30 May 2026 · 0 likes Signalling through cyclic AMP is the canonical pathway and is not the only one. Beta-arrestin recruitment differs between ligands and its clinical significance here is…
Alcohol: what is documented and what is folklore Replied, post #31 · Practice › Interactions · 28 May 2026 · 0 likes SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of concern.
Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #72 · Sourcing › Vendor reports · 24 May 2026 · 22 likes The arithmetic in post #71 is right; the assumption feeding it is the part to check. Do not adjust a reported figure. Post what the laboratory said and put your…
A 10 mg vial reconstituted three different ways, compared Replied, post #21 · Practice › Reconstitution · 21 May 2026 · 1 like Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
Comparing my trajectory with the trial curves, carefully — a second dataset Replied, post #42 · Outcomes › Progress reports · 8 May 2026 · 0 likes Post #41 answers the question as asked. The question underneath it is different. A single scale used throughout beats a more accurate scale introduced halfway through.…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #125 · Pharmacology › Pharmacokinetics · 1 May 2026 · 12 likes The number people quote for Washout is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly uninformative on…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #59 · Outcomes › Body composition · 15 Apr 2026 · 14 likes Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass…
Search filters: what is missing Replied, post #46 · Meta › Site feedback · 13 Apr 2026 · 0 likes Thank you for taking the time. That was more work than a reply usually is.
A single out-of-range value on an otherwise normal panel Replied, post #33 · Clinical › Bloodwork · 11 Apr 2026 · 17 likes Repeat before acting is standard practice for an isolated abnormal result on most analytes, and it is standard for a reason. The disagreement above is smaller than it…
[2026 update] What a purity-only report leaves out Replied, post #81 · Sourcing › Independent verification · 7 Apr 2026 · 19 likes I read post #77 twice before replying, because I had assumed the opposite. The record shows what was measured. Everything beyond that is inference and this site tries…
[2026 update] Thyroid function tests during substantial weight change Replied, post #31 · Clinical › Bloodwork · 5 Apr 2026 · 5 likes Nobody has said the unglamorous part of Thyroid function tests during substantial yet, so: most of the variation is explained by things that are boring to write about…
Measurement error in home scales, with a worked standard deviation — the long version Replied, post #54 · Research Methods › Statistics · 16 Mar 2026 · 4 likes Thank you for taking the time. That was more work than a reply usually is.
Second pass at: Metformin co-administration and additive GI effects Replied, post #58 · Practice › Interactions · 1 Mar 2026 · 4 likes The question underneath Metformin co-administration is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it. Write down…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #123 · Access › International · 22 Feb 2026 · 10 likes Where a jurisdiction has published guidance for clinicians, that document usually answers the practical questions better than any consumer-facing page. The honest…
[2026 update] A rising related-substance total over six months: degradation or method… Replied, post #41 · Analytics › Impurities & related substances · 15 Feb 2026 · 0 likes Worth separating two things that post #37 runs together. Dimer and higher-order multimers: two or more peptide molecules bonded together. They appear at double the mass…
Trifluoroacetate content and its consequences Replied, post #120 · Analytics › Impurities & related substances · 10 Feb 2026 · 1 like Adding what did not work for me on trifluoroacetate content, since the failures never get written up and they are half the useful information.
A site rotation scheme that is easy enough to actually follow Started this topic · Practice › Administration · 2 Feb 2026 · 56 likes On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Two things I would like separated…
Promotion criteria, and the one that stops most nominations — the long version Replied, post #138 · Documentation › Doc review · 23 Jan 2026 · 0 likes Reading rather than answering, but this is the post I would point somebody at.
Reference intervals: how they are constructed and why one in twenty flags Replied, post #38 · Clinical › Bloodwork · 19 Jan 2026 · 10 likes I read post #37 twice before replying, because I had assumed the opposite. Time of day: some biomarkers vary across the day. Cortisol in the morning differs from…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #30 · Documentation › Wiki requests · 9 Jan 2026 · 0 likes Request a new maintained page: if a question recurs, has a good marked solution, and contains a worked example, it is a candidate for promotion to a maintained…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #101 · Analytics › COA interpretation · 31 Dec 2025 · 20 likes Narrowing post #100, because the general version has more than one answer. An itemised related-substances table with retention times says considerably more about the…
What to include when your question involves a chromatogram Replied, post #9 · Start Here › How to Ask · 30 Dec 2025 · 12 likes Clear enough that I do not think I have a follow-up, which is unusual.
What a good consultation looks like from the other side Replied, post #3 · Clinical › Prescriber conversations · 9 Dec 2025 · 0 likes Picking up the opening post: that is the part I would want checked first. Bringing a record of symptoms with dates and severities makes an assessment materially easier…
[2026 update] What steady state means for the decision to escalate Replied, post #67 · Practice › Dosing & titration · 12 Nov 2025 · 4 likes I read post #63 twice before replying, because I had assumed the opposite. Worth stating the null on steady state before we explain it: the observation may be nothing.…
Documentation that appears only after payment Replied, post #67 · Sourcing › Red flags · 4 Nov 2025 · 20 likes Post #65 and I disagree about the size of the effect, not about the direction. Before the thread moves on from documentation — what is the sample size behind the claim?…
The anatomy of a question that gets answered within an hour — the long version Replied, post #36 · Start Here › How to Ask · 29 Oct 2025 · 0 likes Asking a follow-up: new topic or reply in the old one? If the answer depends on the previous post, reply. If it is a question that makes sense without the previous…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #6 · marked as the solution · Access › Pricing · 27 Oct 2025 · 7 likes Careful with the language on Price changes. "Not detected" and "not present" are different findings and the first is a statement about the method.
How the vendor documentation pages are maintained, and by whom — what changed since Replied, post #69 · Sourcing › Vendor reports · 7 Oct 2025 · 0 likes Post #68 is the version of this I will quote in future. One addition. I think the vendor documentation pages question is answerable and has not been answered, which is…
Revisiting: German, French and Dutch differences, compared Replied, post #74 · Regional › European Union · 18 Sep 2025 · 20 likes Netherlands: CBG-MEB implements framework. GPs are first point of contact. Insurance coverage for weight management is conditional on structured lifestyle programme…
A preprint whose numbers changed substantially at publication Replied, post #47 · Evidence › Preprints · 9 Sep 2025 · 4 likes Post #45 put the caveat in the right place and I want to underline it. Peer review catches some things reliably — missing methods, unsupported conclusions, statistical…
Why a pen's dose steps are fixed and what that costs you — one year on Replied, post #35 · Devices › Pens & autoinjectors · 9 Sep 2025 · 0 likes Storage instructions for a pen typically differ before and after first use, and the in-use period is the one people miss. It is on the carton.
What this community means by "a source", in practical terms Replied, post #83 · Start Here › Welcome · 23 Aug 2025 · 15 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
How to read a forest plot, properly, from scratch Replied, post #14 · Evidence › Trials · 10 Aug 2025 · 0 likes Coming back to post #10, because the follow-up matters more than the original answer. Composite endpoints should be read component by component. A composite driven…
A field-by-field walk through a certificate of analysis Replied, post #86 · Analytics › COA interpretation · 16 Jul 2025 · 0 likes Answering the question post #82 raises rather than the one it answers. Asking for the batch record rather than the certificate is a reasonable request and the response…
Why the timeline is on the right and not the left Replied, post #40 · Meta › Site feedback · 12 Jul 2025 · 27 likes This follows post #37 rather than contradicting it. An honest declaration on timeline: I have a prior here and it is strong enough that you should weight what I say…
Why "any advice?" is the least effective ending for a post — the long version Replied, post #17 · Start Here › How to Ask · 25 Jun 2025 · 8 likes On post #15 — agreed on the reasoning, with one qualification. Timeline questions need the timeline. Dates, in order, with what happened on each. "A while ago" and…
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #109 · Compounds › Cagrilintide & amylin analogues · 16 Jun 2025 · 0 likes The honest summary of the evidence base: a coherent mechanism, good phase 2 data in combination, and much less standalone human data than the volume of discussion…
[2026 update] Clearance pathways and what renal impairment changes Replied, post #42 · Pharmacology › Pharmacokinetics · 12 Jun 2025 · 0 likes Answering the question post #40 raises rather than the one it answers. Taking Clearance pathways seriously for a moment rather than deflecting: the honest position is…
Coming back to: An 18-month record including the parts that went badly Replied, post #62 · Outcomes › Progress reports · 6 Jun 2025 · 0 likes Thank you for the correction. I would rather find out here than later.
Talking to a therapist about this specifically — does this still hold? Replied, post #66 · Wellbeing › Mental health · 23 May 2025 · 0 likes Taking post #63 at face value and following it one step further. Motivation and expectation: starting with clear motivation and realistic expectations about what will…
Asking about a compound your prescriber has not heard of Replied, post #40 · Clinical › Prescriber conversations · 15 May 2025 · 0 likes I read post #38 twice before replying, because I had assumed the opposite. If time runs out, asking what to do next — book again, phone, message — is better than…
Metformin co-administration and additive GI effects Replied, post #9 · Practice › Interactions · 22 Apr 2025 · 9 likes Post #5 describes the usual case. This is about the unusual one. Where a published interaction study exists it usually reports an area-under-curve ratio, and that…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #6 · Clinical › Comorbidities · 19 Mar 2025 · 3 likes Coming back to post #2, because the follow-up matters more than the original answer. The arithmetic on Cardiovascular risk is the easy part and it is where the errors…
Delayed gastric emptying and oral medication absorption: which drugs matter Replied, post #15 · Practice › Interactions · 14 Mar 2025 · 29 likes Oral contraceptive absorption has been studied specifically for some compounds in this class and the findings are compound-specific. Generalising from one to another is…
Consistent declarations and why they matter more than clever ones Replied, post #85 · Sourcing › Logistics · 25 Feb 2025 · 23 likes Peak periods and public holidays affect this more than any other factor and are entirely predictable in advance. Reading it back, the second half matters more than the…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #55 · Devices › Cold chain · 20 Feb 2025 · 10 likes Post #53 is right about the mechanism and I think understates the practical bit. The question underneath Domestic fridge temperature mapping is usually "how would I…
A promotion I argued against, and why I lost Replied, post #92 · Documentation › Doc review · 10 Feb 2025 · 12 likes Post #89 is the version of this I will quote in future. One addition. Genuine question rather than a rhetorical one: has anyone here actually observed promotion, as…
Reading a supplementary appendix and finding the interesting part Replied, post #65 · Evidence › Trials · 11 Jan 2025 · 0 likes I read the earlier replies on reading a supplementary appendix twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #81 · Evidence › Journal club · 4 Jan 2025 · 9 likes Coming back to post #79, because the follow-up matters more than the original answer. Filing a mild objection to the consensus on SURPASS-2. Mild because I might be…
Body image changing more slowly than the body Replied, post #90 · Wellbeing › Mental health · 21 Dec 2024 · 11 likes Social and relationship impacts: weight change affects how others perceive and interact with a person. Those impacts are real and can be psychologically significant. I…
Research-use-only status: what it means legally and practically — a second dataset Replied, post #40 · Compounds › Other compounds · 14 Dec 2024 · 27 likes Worth separating two things that post #37 runs together. What I would want before treating Research-use-only status as settled: the method, the sample, and whether…
[2026 update] New subcategory: rationale and scope Replied, post #49 · Meta › Announcements · 7 Dec 2024 · 0 likes Post #45 put the caveat in the right place and I want to underline it. Scheduled maintenance: if the site is going offline for maintenance, advance notice will be…
EMA product information as a primary source — does this still hold? Replied, post #90 · Regional › European Union · 17 Nov 2024 · 21 likes What I want from this EMA product information thread is the list of things that would need to be true for the claim to hold. If we can write that list, we can check it.
Follow-up: Tirzepatide's shorter half-life and its one practical consequence Replied, post #15 · Compounds › Tirzepatide · 30 Oct 2024 · 17 likes Adding a data point of agreement rather than a data point.
Coming back to: Research-use-only labelling: what it means and what it does not Replied, post #6 · marked as the solution · Sourcing › Regulatory · 14 Oct 2024 · 8 likes The arithmetic in post #3 is right; the assumption feeding it is the part to check. Offering a way to settle Research-use-only labelling rather than another opinion…
Revisiting: Melanocortin agonists: mechanism and the documented adverse profile Replied, post #48 · Compounds › Other compounds · 13 Oct 2024 · 2 likes Everything in post #46 holds. The case it does not cover is the one I have. Melanocortin agonists is worth one more sentence than it usually gets, and the sentence is…
Priming a pen and whether the primed volume is wasted — one year on Replied, post #8 · Devices › Pens & autoinjectors · 3 Oct 2024 · 8 likes Nothing here is medical advice, and pen technique is the single easiest thing to have demonstrated in person rather than learned from a description. I have seen it go…
Why a preprint's supplementary material is often the best part Replied, post #36 · Evidence › Preprints · 24 Sep 2024 · 13 likes Always label it as a preprint in any discussion. A preprint is not a published trial and it is not settled knowledge. Use it for hypothesis generation and for…
Guidelines revision: what changed and why Replied, post #35 · Meta › Announcements · 25 Jul 2024 · 29 likes On guidelines revision, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the…