r.torrence

TL2 Member · Nijmegen, NL

Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.

Joined 16 August 2025 · last posted 3d

68 posts, newest first. Showing up to 150.

Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #35 · Compounds › Semaglutide · 25 Jul 2026 · 13 likes Semaglutide formulation looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
GIP receptor agonism and the argument about direction — does this still hold? Replied, post #14 · Pharmacology › Receptor biology · 25 Jul 2026 · 4 likes Amylin receptor signalling: amylin promotes satiety and slows gastric emptying through a receptor distinct from GLP-1. The hypothesis behind combination therapy is two…
Reading order for a first week here, and what to skip until later — what changed since Replied, post #72 · Start Here › Welcome · 22 Jul 2026 · 25 likes That matches what I have seen, for whatever a single anecdote is worth.
Documenting a supplier's response to a discrepancy Replied, post #39 · Sourcing › Vendor reports · 15 Jul 2026 · 3 likes Post #37 and I disagree about the size of the effect, not about the direction. Reports of ordinary results are more valuable than reports of remarkable ones, precisely…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #28 · Practice › Dosing & titration · 30 Jun 2026 · 16 likes Where I part company with post #24, and it is a narrow parting. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add…
Why the timeline is on the right and not the left — what changed since Replied, post #64 · Meta › Site feedback · 29 Jun 2026 · 6 likes If you are new and reading this thread for the answer to timeline: the answer is conditional, the conditions are in the third reply, and the rest of the thread is worth…
GLP-1 receptor distribution: central and peripheral Replied, post #78 · Pharmacology › Receptor biology · 27 Jun 2026 · 0 likes Adding a note of thanks rather than an opinion. I did not know most of that.
Secretagogues and glucose tolerance: the mechanistic concern Replied, post #41 · Compounds › Secretagogues & GH axis · 19 Jun 2026 · 0 likes This follows post #38 rather than contradicting it. Summarising the secretagogues and glucose tolerance thread so far, since it is long and the answer is buried: the…
Submitting a sample: the process end to end Replied, post #12 · Sourcing › Independent verification · 11 Jun 2026 · 12 likes Careful with the language on submitting a sample. "Not detected" and "not present" are different findings and the first is a statement about the method.
Angle of injection and whether 90 degrees is always right — the long version Replied, post #20 · Practice › Administration · 9 Jun 2026 · 23 likes This is the first time the answer has come with its own limits attached. Appreciated.
Official shortage notices and what they authorise Replied, post #93 · Access › Shortages · 7 Jun 2026 · 1 like Shortages end and the notices are updated. Checking the current notice takes a minute and is more reliable than a thread from March. The literature is thinner on this…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #95 · Sourcing › Red flags · 6 Jun 2026 · 0 likes Reporting something here requires the batch, the date, the method and the document, which is exactly what makes the reports worth reading two years later.
What a certificate commits its issuer to — one year on Replied, post #77 · Analytics › COA interpretation · 28 May 2026 · 18 likes That is consistent with mine, for whatever one more account is worth.
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #84 · Outcomes › Body composition · 27 May 2026 · 4 likes The reason Lean mass preservation keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.
How this community labels and discusses unrefereed work — the long version Replied, post #7 · Evidence › Preprints · 11 May 2026 · 5 likes The practical version of community labels is three sentences long. The rigorous version is three pages and reaches the same conclusion with the conditions attached.
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #21 · Analytics › HPLC & UHPLC · 3 May 2026 · 25 likes Peak purity: a diode-array detector records a spectrum at every time point. If a peak contains two co-eluting species with different spectra, the spectrum changes…
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #92 · Compounds › Tirzepatide · 21 Apr 2026 · 0 likes 2.5 mg starting dose: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like…
Amylin receptor signalling and satiety — what changed since Replied, post #58 · Pharmacology › Receptor biology · 8 Apr 2026 · 0 likes Receptor distribution explains the side-effect profile better than anything else. GLP-1 receptors in the gastrointestinal tract and the area postrema account for most…
EU-wide position versus national implementation — what changed since Replied, post #22 · Regional › European Union · 5 Apr 2026 · 1 like Post #21 answers the question as asked. The question underneath it is different. I read the earlier replies on eu-wide position versus national implementation twice…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #79 · Analytics › Mass spectrometry · 23 Mar 2026 · 19 likes Resolution and mass accuracy are different specifications. An instrument can resolve two species and still assign their masses imprecisely, and the reverse is also…
Revisiting: Absolute versus relative contraindications Replied, post #48 · Safety › Contraindications · 21 Mar 2026 · 18 likes Narrowing post #45, because the general version has more than one answer. The strongest argument against my own position on Absolute versus relative contraindications,…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #76 · Compounds › Cagrilintide & amylin analogues · 19 Mar 2026 · 0 likes Historical amylin analogues: pramlintide was the only long-acting amylin analogue licensed for some time and its poor adherence was a known limitation. A weekly…
Guidelines revision: what changed and why — one year on Replied, post #76 · Meta › Announcements · 28 Feb 2026 · 0 likes Reading the changed pages: the diff is smaller than the announcement implies, which is reassuring rather than disappointing. A large change to a documentation page…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #123 · Practice › Dosing & titration · 21 Feb 2026 · 20 likes The arithmetic in post #122 is right; the assumption feeding it is the part to check. If you are stepping up mainly because the schedule says so rather than because the…
Reused chromatograms across lots: how to spot it — what changed since Replied, post #16 · Analytics › COA interpretation · 8 Feb 2026 · 1 like Post #14 and I disagree about the size of the effect, not about the direction. A chromatogram supplied as a small image is legible for peak shape and not for baseline…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #20 · Practice › Storage & stability · 17 Jan 2026 · 0 likes Narrowing post #19, because the general version has more than one answer. Published stability data applies specifically to the formulation studied, under the specific…
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #39 · Practice › Storage & stability · 21 Dec 2025 · 19 likes Narrowing post #38, because the general version has more than one answer. Reconstituted material carried in a bag for a day is a temperature excursion even in a cool…
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly — the long… Replied, post #61 · Compounds › Tirzepatide · 9 Dec 2025 · 12 likes The arithmetic in post #60 is right; the assumption feeding it is the part to check. On purity: the trailing-edge features people report on tirzepatide chromatograms…
Heterogeneity as information rather than as a nuisance Replied, post #10 · Evidence › Meta-analyses · 28 Nov 2025 · 1 like Quality assessment of included trials should change the analysis rather than sit beside it. A sensitivity analysis excluding the weakest studies is the minimum. The…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #69 · Compounds › Tirzepatide · 22 Oct 2025 · 12 likes Fair, and the limits you put on it are the part I will remember.
Research-use-only status: what it means legally and practically — does this still hold? Replied, post #3 · Compounds › Other compounds · 21 Oct 2025 · 0 likes Narrowing post #2, because the general version has more than one answer. Research-use-only status is a legal classification, not a safety classification. It means the…
New subcategory: rationale and scope Replied, post #36 · Meta › Announcements · 16 Oct 2025 · 7 likes On new subcategory I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #13 · Start Here › Welcome · 12 Oct 2025 · 12 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #11 · Research Methods › N-of-1 designs · 12 Oct 2025 · 3 likes Objective versus subjective measures: subjective measures (how you feel) are vulnerable to bias. Objective measures (weight, strength on a specific exercise) are less…
Sleep quality changes during weight loss — what changed since Replied, post #14 · Wellbeing › Sleep · 1 Oct 2025 · 17 likes Sleep-disordered breathing improving with weight reduction is one of the better-evidenced downstream effects, and the trial that measured it used an objective index…
Which panel is worth repeating and which is worth ignoring Replied, post #125 · Clinical › Bloodwork · 30 Sep 2025 · 7 likes Where the panel reasoning breaks down for me is the step from the group result to the individual case. That step is almost never argued for.
Pages past their review date, listed Replied, post #24 · Meta › Wiki maintenance · 30 Aug 2025 · 14 likes Taking post #21 at face value and following it one step further. Small correction to my own earlier position on pages past. I had the units the wrong way round, which…
The most useful thing you learned here that was not the answer you came for — a second… Replied, post #10 · Lounge › Off topic · 28 Aug 2025 · 2 likes Adjacent and interesting: you might post something about nutrition, bioavailability from a food perspective, or the sociology of weight. Adjacent to this community's…
[2026 update] Journal club: is percentage weight change the right endpoint? Replied, post #74 · Evidence › Journal club · 20 Aug 2025 · 9 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. Two sources, same…
A request that was declined, and the reasoning — a second dataset Replied, post #99 · Documentation › Wiki requests · 16 Aug 2025 · 0 likes Narrowing post #98, because the general version has more than one answer. A request is more likely to succeed with a proposed outline attached. "Somebody should write…
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #41 · Compounds › Semaglutide · 13 Aug 2025 · 0 likes Distinguishing three things in the semaglutide versus liraglutide discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the…
Gauge and length selection for subcutaneous injection Replied, post #16 · Devices › Syringes & needles · 30 Jul 2025 · 3 likes Where I part company with post #12, and it is a narrow parting. Silicone coating on the barrel affects how smoothly the plunger moves and how a very slow injection…
Revisiting: Why a compound being unapproved is not the same as being illegal to possess Replied, post #37 · Sourcing › Regulatory · 29 Jun 2025 · 6 likes Compound being unapproved would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
Second pass at: Semaglutide and alcohol: what is actually documented Replied, post #20 · Compounds › Semaglutide · 29 Jun 2025 · 7 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
Excipient function in a licensed injectable Replied, post #8 · Pharmacology › Formulation chemistry · 31 May 2025 · 0 likes A note on how excipient function gets discussed rather than on excipient function itself: the confident posts get the replies and the careful ones get ignored, and the…
Revisiting: GLP-1 receptor distribution: central and peripheral Started this topic · Pharmacology › Receptor biology · 18 May 2025 · 27 likes Revisiting: GLP-1 receptor distribution: central and peripheral — setting out what I have, and where I think it stops being reliable. An honest uncertainty about GLP-1…
Why "any advice?" is the least effective ending for a post — the long version Replied, post #4 · Start Here › How to Ask · 18 May 2025 · 12 likes Coming back to the opening post, because the follow-up matters more than the original answer. Quantities without units are the single commonest reason a question sits…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #121 · Compounds › Semaglutide · 17 May 2025 · 0 likes Injection site does not appear to matter much for semaglutide exposure. The published comparisons of abdomen, thigh and upper arm found differences small enough to be…
Reading a trial's population section before its results — does this still hold? Replied, post #70 · Evidence › Trials · 5 May 2025 · 16 likes Reading the supplementary appendix is where most of the real information is, and it is where almost nobody goes. The baseline table alone answers half the…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #123 · Evidence › Journal club · 22 Apr 2025 · 23 likes The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.…
Reconstituting a multi-strength kit without mixing yourself up Replied, post #60 · Practice › Reconstitution · 21 Apr 2025 · 17 likes I had written a reply contradicting post #56 and deleted it. Here is what survived. Preservative effectiveness is tested against a defined microbial challenge under…
A well-designed study with a badly written abstract Replied, post #28 · Evidence › Study critique · 17 Apr 2025 · 9 likes Offering a way to settle well-designed study rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within…
UK access routes, dated and sourced — a second dataset Replied, post #64 · Regional › UK & Ireland · 15 Apr 2025 · 2 likes Seconded. It reads as careful rather than confident, which is the right register.
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #73 · Compounds › Semaglutide · 11 Apr 2025 · 31 likes SELECT has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.
Antibiotics and a course of something with delayed emptying Replied, post #17 · Practice › Interactions · 8 Apr 2025 · 15 likes A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is…
Follow-up: Open-label extensions: what survives and what does not Replied, post #21 · Evidence › Trials · 29 Mar 2025 · 23 likes Everything in post #19 holds. The case it does not cover is the one I have. Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not…
Maintainer handover: how it works Replied, post #63 · Meta › Wiki maintenance · 18 Mar 2025 · 5 likes Useful. I had the fact and not the reason, which turns out to be the important half.
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Replied, post #19 · Compounds › Secretagogues & GH axis · 4 Mar 2025 · 0 likes Reading back through the Tesamorelin threads from last year, the same three questions come up every time and only one of them has ever been answered properly. That…
A supplier that answers analytical questions with restated claims Replied, post #31 · Sourcing › Red flags · 27 Feb 2025 · 29 likes That reframing is the whole thing. The facts I already had.
Consistent declarations and why they matter more than clever ones Replied, post #59 · Sourcing › Logistics · 20 Feb 2025 · 1 like Recording ordinary deliveries is what makes the record useful. A file of only the bad ones cannot tell you the rate. Noting that I have skin in this question and have…
Coming back to: Renal impairment: what the labelling says about dose Replied, post #29 · Clinical › Special populations · 14 Jan 2025 · 0 likes Answering the question post #27 raises rather than the one it answers. Genetic and ancestry-related differences in response are asked about regularly and the published…
Coming back to: Grapefruit: why this class is not the class that cares Replied, post #47 · Practice › Interactions · 10 Jan 2025 · 16 likes An observation about Grapefruit that I cannot explain and am posting anyway, on the principle that unexplained observations are more useful public than private.
The report format the maintainers ask for, and why each field is there — what changed… Replied, post #3 · Sourcing › Vendor reports · 1 Jan 2025 · 1 like Worth separating two things that the opening post runs together. Where you have no independent result, a documentation report is still worth filing: what the…
Injection-site reactions: describing them precisely enough to be useful Replied, post #26 · Practice › Side effects · 26 Nov 2024 · 3 likes Post #24 is right about the mechanism and I think understates the practical bit. Two things can be true about injection-site reactions at once: the mechanism is…
Food noise reducing and the disorientation that can follow Replied, post #27 · Wellbeing › Mental health · 23 Oct 2024 · 23 likes What I would want before treating food noise as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually…
Transit times by route, from a logged dataset — the long version Replied, post #7 · Sourcing › Logistics · 23 Aug 2024 · 16 likes Transit times was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.
Identical chromatograms across two different lots Replied, post #12 · Sourcing › Red flags · 6 Aug 2024 · 0 likes Coming back to post #8, because the follow-up matters more than the original answer. I would put moderate confidence on the mainstream reading of identical…
How this community labels and discusses unrefereed work Replied, post #120 · Evidence › Preprints · 28 Jul 2024 · 12 likes Checked the community labels claim against the primary source this morning. It survives, with a narrower scope than the version quoted here. Posting the narrower scope.