f.haddad

TL2 · Groningen

Contributes reviews on supplier material. Based in Groningen.

Joined 27 March 2025 · last posted 3d

108 posts, newest first. Showing up to 150.

[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #107 · Access › International · 25 Jul 2026 · 13 likes Both are useful and they are different contributions. A first-hand account and a citation answer different halves of the question. Anyone who has looked at this more…
Follow-up: Signs of dehydration worth acting on Replied, post #26 · Safety › Adverse events · 15 Jul 2026 · 2 likes The useful distinction on Signs of dehydration worth acting is between what was measured and what was inferred from it. Both end up in the same sentence and only one of…
Follow-up: How compounding permissions changed when supply normalised Replied, post #23 · Sourcing › Regulatory · 15 Jul 2026 · 0 likes An indication approved for one age range does not extend to another, and paediatric extensions are separate decisions with separate evidence. I would want a second…
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #59 · Practice › Dosing & titration · 12 Jul 2026 · 18 likes The maximum studied dose is a fact about the trial and not a ceiling on the molecule. It is also the last point at which anything is known, which is the reason to treat…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #118 · Evidence › Journal club · 12 Jul 2026 · 0 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. It is one reading…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #52 · Compounds › Retatrutide · 10 Jul 2026 · 9 likes Confirming post #51 from a second method, which matters more than confirming it from a second person. What we do not know about retatrutide, listed explicitly:…
Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #57 · Analytics › Impurities & related substances · 8 Jul 2026 · 0 likes This follows post #56 rather than contradicting it. A supplier that can tell you what its principal impurity is has answered a harder question than one that can tell…
Submitting a sample: the process end to end Replied, post #57 · Sourcing › Independent verification · 4 Jul 2026 · 0 likes I read post #55 twice before replying, because I had assumed the opposite. The strongest argument against my own position on submitting a sample, stated as well as I…
Tracking a shortage from primary sources rather than rumour Replied, post #71 · Access › Shortages · 26 Jun 2026 · 8 likes Fair, and the limits you put on it are the part I will remember.
NHS criteria and how they are applied in practice Replied, post #7 · Regional › UK & Ireland · 20 Jun 2026 · 8 likes I read the earlier replies on NHS criteria twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was said…
What steady state means for the decision to escalate Replied, post #14 · Practice › Dosing & titration · 15 Jun 2026 · 23 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose. A…
Racemisation and why it is invisible to a mass measurement Replied, post #122 · Analytics › Impurities & related substances · 15 Jun 2026 · 2 likes That matches what I have seen, for whatever a single anecdote is worth.
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #108 · Practice › Storage & stability · 9 Jun 2026 · 0 likes Dating prepared solutions: write the date reconstitution on the vial in permanent marker. If you later need to know whether it has been sitting for weeks or days, the…
Electrolyte supplements: which ones do anything Replied, post #23 · Nutrition & Training › Hydration & electrolytes · 4 Jun 2026 · 4 likes Picking up post #20: that is the part I would want checked first. Checked the electrolyte supplements claim against the primary source this morning. It survives, with a…
Counter-ion form: the field almost nobody reports Replied, post #4 · Analytics › COA interpretation · 2 Jun 2026 · 12 likes Purity and content are different measurements: purity tells you what proportion of the detected material is the intended species. Content tells you how much of the…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #53 · Practice › Storage & stability · 1 Jun 2026 · 31 likes Taking post #50 at face value and following it one step further. Temperature excursions in transit are common and are not all equal. A few hours warm is a different…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #20 · Compounds › Oral incretins · 30 May 2026 · 0 likes Grateful for the specificity. Vague answers to this question are what sent me looking.
Research-use-only status: what it means legally and practically Replied, post #41 · Compounds › Other compounds · 12 May 2026 · 9 likes Worth separating two things that post #39 runs together. Two sentences on research-use-only status and then I will stop, because the rest is speculation and the thread…
Fixed versus detachable needles: the trade-offs — does this still hold? Replied, post #2 · Devices › Syringes & needles · 27 Apr 2026 · 4 likes Coring the stopper is a real phenomenon with repeated entries at the same point and blunt needles. Varying the entry point slightly and using a fresh needle prevents it.
Sample handling between despatch and injection Replied, post #56 · Analytics › Method validation · 21 Apr 2026 · 17 likes Everything in post #52 holds. The case it does not cover is the one I have. Having read the whole sample handling between despatch thread before replying: the question…
Journal club: SURMOUNT-4 and continuation versus withdrawal Replied, post #26 · Evidence › Journal club · 10 Apr 2026 · 21 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
A site rotation scheme that is easy enough to actually follow Replied, post #37 · Practice › Administration · 9 Apr 2026 · 25 likes Site rotation scheme is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
Tesamorelin has an approved indication — what that changes about the evidence Started this topic · Compounds › Secretagogues & GH axis · 9 Apr 2026 · 0 likes Tesamorelin has an approved indication — what that changes about the evidence — setting out what I have, and where I think it stops being reliable. What changes if the…
Anaesthesia and elective surgery: the aspiration question Replied, post #78 · Practice › Interactions · 8 Apr 2026 · 0 likes SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #116 · Clinical › Bloodwork · 31 Mar 2026 · 1 like Right — I had this wrong and I am glad to have read it before it mattered.
Insomnia at a dose step: reported experiences — the long version Replied, post #7 · Wellbeing › Sleep · 31 Mar 2026 · 31 likes Reporting rather than recommending, on Insomnia. What happened is above. Whether it should have is a different question and not one I am qualified to answer.
Sulfonylureas: the interaction most worth taking seriously Replied, post #4 · Practice › Interactions · 29 Mar 2026 · 22 likes SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular discussion, not to interactions. There is no pharmacokinetic interaction of…
Personal import allowances, compared — a second dataset Replied, post #91 · Access › International · 24 Mar 2026 · 2 likes Import rules for personal quantities are jurisdiction-specific and change without much publicity. Establishing your own position is unavoidable.
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #77 · Start Here › How to Ask · 23 Mar 2026 · 4 likes Building on post #74 rather than restating it. It is fine to say you cannot explain why you are asking. Nobody will press, and the technical part of the question can…
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #100 · Lounge › Introductions · 18 Mar 2026 · 17 likes Hello and welcome. One practical suggestion: watch two subcategories rather than the whole site. The firehose is real and it puts people off in the first fortnight.…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #54 · Research Methods › N-of-1 designs · 13 Mar 2026 · 25 likes No disagreement from me. Posting only so the question does not look ignored.
Reading an interaction checker output critically Replied, post #132 · Practice › Interactions · 28 Feb 2026 · 8 likes On post #130 — agreed on the reasoning, with one qualification. Supplements and herbs: many have no established interaction. Some do. If you are taking something…
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #130 · Compounds › Semaglutide · 27 Feb 2026 · 0 likes Semaglutide half-life is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Whether protein timing matters at a large deficit Replied, post #28 · Nutrition & Training › Protein & intake · 24 Feb 2026 · 0 likes Micronutrient adequacy becomes a real question at very low total intake and is much less discussed than protein.
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #7 · Practice › Dosing & titration · 14 Feb 2026 · 0 likes Escalating before steady state means you are judging a dose you have not yet fully experienced. That is the whole argument against compressing the schedule and it is a…
Specification in the result column: why that is a meaningful error Replied, post #119 · Analytics › COA interpretation · 8 Feb 2026 · 0 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #18 · Outcomes › Progress reports · 8 Feb 2026 · 0 likes Post #15 is right about the mechanism and I think understates the practical bit. Maintenance series are the ones this subcategory needs most and receives least. The…
Reconciling a label claim with a content assay Replied, post #6 · Analytics › COA interpretation · 4 Feb 2026 · 7 likes I read post #4 twice before replying, because I had assumed the opposite. Amino acid analysis gives content: it hydrolyses the peptide and quantifies the residues. It…
Why a compound being unapproved is not the same as being illegal to possess Replied, post #55 · Sourcing › Regulatory · 1 Feb 2026 · 1 like Marking my uncertainty on compound being unapproved explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it…
Packaging that arrived damaged: documenting it properly — a second dataset Replied, post #29 · Sourcing › Logistics · 28 Jan 2026 · 0 likes Document outcomes rather than forecasting them. A forecast in this category reads as reassurance and is not one.
Preprint servers and what screening they do Replied, post #26 · Evidence › Preprints · 16 Jan 2026 · 14 likes One more thing on preprint servers that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the…
Muscle cramps: the ordinary causes before the exotic ones Replied, post #33 · Practice › Side effects · 15 Jan 2026 · 6 likes The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
A partial dose because the pen emptied mid-injection Replied, post #39 · Practice › Administration · 8 Jan 2026 · 0 likes The arithmetic in post #36 is right; the assumption feeding it is the part to check. If you have to inject at a different time of day than usual, that is a much smaller…
Alcohol: what is documented and what is folklore — the long version Replied, post #10 · Practice › Interactions · 5 Jan 2026 · 2 likes Building on post #8 rather than restating it. Alcohol is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will…
Vomiting: when it is expected and when it is a reason to stop Replied, post #56 · Practice › Side effects · 28 Dec 2025 · 24 likes The practical division worth making is between symptoms that are unpleasant, symptoms that are limiting, and symptoms that are a reason to stop and get assessed. They…
Why "add 2 mL" is not an instruction Replied, post #21 · Practice › Reconstitution · 25 Dec 2025 · 1 like Coming back to post #19, because the follow-up matters more than the original answer. Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and…
Second pass at: The topic list is dense — is that deliberate? Replied, post #22 · Meta › Site feedback · 17 Dec 2025 · 15 likes Taking post #21 at face value and following it one step further. I disagree with the framing of topic list above, and I think it is a substantive disagreement rather…
Tracking a preprint to publication: a worked example Replied, post #118 · Evidence › Preprints · 12 Dec 2025 · 3 likes Post #117 answers the question as asked. The question underneath it is different. A preprint with the data and code attached is frequently more checkable than a…
Publishing an inconvenient result: a case study — the long version Replied, post #47 · Sourcing › Independent verification · 24 Nov 2025 · 0 likes Right — I had this wrong and I am glad to have read it before it mattered.
Interpreting a result that disagrees with the supplier's certificate Replied, post #19 · Sourcing › Independent verification · 21 Nov 2025 · 8 likes Nothing to add on the substance. Thank you for taking the question at face value.
The anatomy of a question that gets answered within an hour — the long version Replied, post #89 · Start Here › How to Ask · 12 Nov 2025 · 0 likes Everything in post #87 holds. The case it does not cover is the one I have. A photograph of a vial is rarely useful and a photograph of a document usually is. Redact…
What a purity-only report leaves out Replied, post #82 · Sourcing › Independent verification · 11 Nov 2025 · 1 like I have three months of notes on purity-only and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite…
How to read a forest plot, properly, from scratch Replied, post #52 · Evidence › Trials · 8 Nov 2025 · 25 likes Where I part company with post #50, and it is a narrow parting. Absolute numbers, not just relative: a 30% relative reduction tells you the ratio but not the practical…
Half-life, steady state, and accumulation worked through — a second dataset Replied, post #12 · Pharmacology › Pharmacokinetics · 1 Nov 2025 · 14 likes The accumulation ratio for weekly dosing with a week-long half-life is around two, which is why the concentration after several doses is roughly double the…
What a purity-only report leaves out Replied, post #67 · Sourcing › Independent verification · 31 Oct 2025 · 24 likes Small methodological point on purity-only: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
Where to report an adverse event officially, by region — a second dataset Replied, post #67 · Safety › Adverse events · 29 Oct 2025 · 24 likes Adding the measurement that post #64 says would settle it. Psychological adverse events: mood changes, anxiety, or suicidal ideation warrant discussion with a mental…
Why oral semaglutide needs an absorption enhancer at all Replied, post #41 · Compounds › Oral incretins · 14 Oct 2025 · 0 likes PIONEER 6 is the cardiovascular outcome trial for oral semaglutide and it enrolled a diabetes population at high cardiovascular risk. Quoting it outside that population…
Hypertension improvement and when medication needs revisiting Replied, post #68 · Clinical › Comorbidities · 18 Sep 2025 · 11 likes Building on post #65 rather than restating it. Where somebody is on several medicines, the interaction question and the comorbidity question are entangled and both…
Payment method and the leverage it gives you, ranked Replied, post #17 · Sourcing › Payments · 15 Sep 2025 · 16 likes Adding a null result on payment method. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.
Documentation that appears only after payment Replied, post #21 · Sourcing › Red flags · 9 Sep 2025 · 0 likes The most useful contribution to this subcategory is a resolved case written up with the resolution, because the unresolved ones are all anyone remembers. The claim is…
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #24 · Analytics › Method validation · 31 Aug 2025 · 0 likes Everything in post #20 holds. The case it does not cover is the one I have. The most useful single question about a method: what would it fail to detect? Every method…
A parcel that arrived warm: a decision process, not a verdict Replied, post #18 · Practice › Storage & stability · 30 Aug 2025 · 0 likes Where I part company with post #16, and it is a narrow parting. Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation…
Thyroid function tests during substantial weight change Replied, post #45 · Clinical › Bloodwork · 29 Aug 2025 · 6 likes The failure mode on thyroid function tests during substantial is boring rather than dramatic. It is almost always the step everyone assumes was done correctly because…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #39 · Analytics › HPLC & UHPLC · 28 Aug 2025 · 5 likes That reframing is the whole thing. The facts I already had.
Titles that describe the question, not the situation Replied, post #59 · Start Here › How to Ask · 29 Jul 2025 · 0 likes Narrowing post #56, because the general version has more than one answer. Chromatogram questions: describe the method first. Column type, gradient, wavelength,…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #59 · Compounds › Oral incretins · 5 Jul 2025 · 0 likes The practical argument for an oral is adherence, and the published adherence data is less flattering than the argument. Daily dosing with fasting requirements is not…
Coming back to: Official shortage notices and what they authorise Replied, post #44 · Access › Shortages · 30 Jun 2025 · 28 likes Adding the measurement that post #43 says would settle it. Worth stating the null on Official shortage notices before we explain it: the observation may be nothing.…
Repeatability versus intermediate precision Replied, post #44 · Analytics › Method validation · 23 Jun 2025 · 10 likes This is the sort of exchange that makes the archive worth searching.
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #140 · Practice › Reconstitution · 20 Jun 2025 · 2 likes Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #29 · Compounds › Repair & healing peptides · 2 Jun 2025 · 25 likes Coming back to post #25, because the follow-up matters more than the original answer. Oral versus injected administration claims for BPC-157: the preclinical work…
Validating a calculator against hand arithmetic — what changed since Replied, post #93 · Data & Tools › Calculators · 26 May 2025 · 1 like Summarising the Validating a calculator against hand thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the…
Second pass at: Designing a personal experiment that could change your mind Replied, post #23 · Research Methods › N-of-1 designs · 19 May 2025 · 22 likes Committing to post the result before you know it is a useful precommitment, and this subcategory is a reasonable place to make it. Flagging that the sources on this are…
Validating a calculator against hand arithmetic — what changed since Replied, post #72 · Data & Tools › Calculators · 16 May 2025 · 5 likes Narrowing post #71, because the general version has more than one answer. Tools that run entirely in the browser send nothing anywhere, which matters more to some…
Coverage for the indication versus for the drug Replied, post #68 · Access › Insurance & coverage · 16 May 2025 · 19 likes This follows post #67 rather than contradicting it. Keep every document with dates in one place. An appeal months later is assembled from whatever you kept. That…
DXA precision and the least significant change for lean mass — the long version Replied, post #24 · Outcomes › Body composition · 10 May 2025 · 0 likes On post #22 — agreed on the reasoning, with one qualification. Precision versus accuracy: the precision you need depends on what question you are answering. "Am I…
Titles that describe the question, not the situation Replied, post #7 · Start Here › How to Ask · 7 May 2025 · 6 likes Answering the question post #3 raises rather than the one it answers. What I would want before treating titles as settled: the method, the sample, and whether anyone…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #42 · Sourcing › Independent verification · 3 May 2025 · 11 likes Picking up post #39: that is the part I would want checked first. What I would check first on Janoshik is whether the thing being measured moved or whether the way of…
Publishing an inconvenient result: a case study Replied, post #13 · Sourcing › Independent verification · 28 Apr 2025 · 4 likes Post #11 put the caveat in the right place and I want to underline it. Filing a mild objection to the consensus on publishing an inconvenient result. Mild because I…
Metformin co-administration and additive GI effects Replied, post #13 · Practice › Interactions · 24 Apr 2025 · 21 likes Building on post #10 rather than restating it. The most defensible general position in this subcategory: identify the plausible mechanism, check whether it has been…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #41 · Evidence › Journal club · 19 Apr 2025 · 0 likes This follows post #38 rather than contradicting it. I have no financial interest in anything named in this thread and I want to say so before I comment on STEP 1,…
Follow-up: Documentation that appears only after payment Replied, post #6 · Sourcing › Red flags · 18 Apr 2025 · 5 likes I had written a reply contradicting post #2 and deleted it. Here is what survived. Where the same certificate image appears with different lot numbers, that is a…
Which panel is worth repeating and which is worth ignoring Started this topic · Clinical › Bloodwork · 5 Apr 2025 · 41 likes The question in the title: Which panel is worth repeating and which is worth ignoring I will give what I have already checked below so nobody repeats it. An honest…
Fibre intake when total intake falls, and the constipation link Replied, post #47 · Nutrition & Training › Protein & intake · 31 Mar 2025 · 20 likes Where I part company with post #45, and it is a narrow parting. Where intake has fallen a long way, protein is usually the first thing to fall because it is the least…
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Replied, post #126 · Compounds › Semaglutide · 11 Mar 2025 · 21 likes Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #112 · Sourcing › Regulatory · 4 Mar 2025 · 0 likes The version of pharmaceutical compounding rules that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
Why we hide unevidenced fraud accusations and log the hiding Replied, post #48 · Sourcing › Red flags · 5 Feb 2025 · 0 likes Post #46 describes the usual case. This is about the unusual one. The most useful contribution to this subcategory is a resolved case written up with the resolution,…
What we do not know about retatrutide, listed explicitly Replied, post #77 · Compounds › Retatrutide · 31 Jan 2025 · 2 likes Following, with nothing to contribute beyond having asked the same thing elsewhere.
Dose numbers for oral formulations are not comparable to injectable ones — a second… Replied, post #52 · Compounds › Oral incretins · 15 Jan 2025 · 3 likes The gastrointestinal tolerability profile of the oral formulation is broadly similar in character to the injectable, which supports the effects being systemic rather…
Follow-up: Individual participant data versus aggregate data Replied, post #13 · Evidence › Meta-analyses · 8 Jan 2025 · 0 likes Double extraction with disagreement resolution is standard and is worth checking for, because single extraction errors are common and non-random.
UK access routes, dated and sourced — a second dataset Replied, post #23 · Regional › UK & Ireland · 4 Jan 2025 · 0 likes Post #21 is the version of this I will quote in future. One addition. Waiting times are the most variable and least generalisable thing reported here, and they are…
Oxidation pathways for methionine and tryptophan Replied, post #7 · Analytics › Impurities & related substances · 25 Dec 2024 · 0 likes The arithmetic in post #4 is right; the assumption feeding it is the part to check. Practical experience of oxidation pathways for methionine, offered as one case with…
[2026 update] Lipid changes during rapid weight loss: the expected trajectory Started this topic · Clinical › Bloodwork · 25 Dec 2024 · 54 likes Lipid changes during rapid weight loss: the expected trajectory Writing it up because I had to work it out twice and would rather nobody else did. Lipid changes during…
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #83 · Compounds › Semaglutide · 24 Dec 2024 · 13 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Follow-up: Dead volume across syringe and needle combinations Replied, post #80 · Devices › Syringes & needles · 11 Dec 2024 · 8 likes Worth separating two things that post #76 runs together. Coring the stopper is a real phenomenon with repeated entries at the same point and blunt needles. Varying the…
Washout with a one-week half-life: the arithmetic Replied, post #31 · Research Methods › N-of-1 designs · 28 Nov 2024 · 0 likes The version of washout that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #45 · Clinical › Special populations · 23 Nov 2024 · 12 likes Dedicated trials in under-studied populations are the only real remedy and several are ongoing, which is worth saying rather than speculating. Genuinely open to being…
Follow-up: Recovery when intake is low: what to cut first Replied, post #39 · Nutrition & Training › Resistance training · 23 Nov 2024 · 0 likes I had written a reply contradicting post #35 and deleted it. Here is what survived. Frequency: three sessions per week of full-body training is easier to maintain than…
What we do not know about retatrutide, listed explicitly Started this topic · Compounds › Retatrutide · 18 Nov 2024 · 8 likes The question in the title: What we do not know about retatrutide, listed explicitly I will give what I have already checked below so nobody repeats it. Setting out what…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #35 · Evidence › Journal club · 17 Nov 2024 · 0 likes SELECT (N Engl J Med 2023): Semaglutide cardiovascular outcomes without diabetes. The first outcome trial in people without diabetes, which decoupled the cardiovascular…
Why "any advice?" is the least effective ending for a post Replied, post #44 · Start Here › How to Ask · 17 Nov 2024 · 7 likes Say what you want out of the answer. "I want to know whether to accept this delivery" and "I want to understand the chemistry" get very different and equally valid…
Revisiting: Moderation log format change Replied, post #25 · Meta › Announcements · 12 Nov 2024 · 17 likes Worth saying publicly: stepping back cleanly and handing over is a service. Documents with an absent maintainer go wrong quietly, which is the worst way for them to go…
Isotope patterns and why the monoisotopic peak is not the tallest Replied, post #2 · Analytics › Mass spectrometry · 8 Nov 2024 · 3 likes Monoisotopic and average mass are different numbers and both appear on documents. At this molecular weight the difference is a few daltons, which is more than the…
Why "any advice?" is the least effective ending for a post Replied, post #6 · Start Here › How to Ask · 3 Nov 2024 · 5 likes Lab result questions: state the result, the reference interval, and what else is on the same panel. A single flag on a single draw is usually uninformative without…
Coming back to: Oxidation pathways for methionine and tryptophan Replied, post #2 · Analytics › Impurities & related substances · 24 Oct 2024 · 19 likes The opening post is right about the mechanism and I think understates the practical bit. Trying to state the Oxidation pathways for methionine position in a way that…
Requesting a page: what makes a good request — what changed since Replied, post #128 · Documentation › Wiki requests · 13 Oct 2024 · 21 likes Post #127 is the version of this I will quote in future. One addition. Translation suggestions: if a maintained page should exist in another language, suggesting it…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #9 · marked as the solution · Compounds › Cagrilintide & amylin analogues · 9 Oct 2024 · 11 likes If someone has run amylin analogue mechanism properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
Progressive overload when the scale is falling — one year on Replied, post #19 · Nutrition & Training › Resistance training · 1 Sep 2024 · 21 likes Cardiovascular work has its own benefits and is not a substitute for a resistance stimulus for this particular purpose.
Journal club: FLOW and the renal composite, component by component Replied, post #70 · Evidence › Journal club · 16 Jul 2024 · 0 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…