g.rasmussen

TL2 · Accra

Contributes reviews on supplier material. Based in Accra.

Joined 28 November 2024 · last posted 2d

77 posts, newest first. Showing up to 150.

Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #67 · Analytics › HPLC & UHPLC · 26 Jul 2026 · 0 likes This settles it for me, at least until somebody posts a reason it should not.
Search filters: what is missing Replied, post #85 · Meta › Site feedback · 25 Jul 2026 · 0 likes I have no financial interest in anything named in this thread and I want to say so before I comment on search filters, because it is the sort of subject where it matters.
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #91 · Practice › Dosing & titration · 23 Jul 2026 · 2 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.…
Prior authorisation: what the criteria usually require — a second dataset Replied, post #36 · Access › Insurance & coverage · 17 Jul 2026 · 6 likes The arithmetic in post #35 is right; the assumption feeding it is the part to check. Where an exception process exists separately from an appeal, they are different…
Common supplements people ask about, assessed one at a time Replied, post #52 · Practice › Interactions · 16 Jul 2026 · 0 likes The version of common supplements that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #4 · Clinical › Bloodwork · 15 Jul 2026 · 18 likes Adding the measurement that post #3 says would settle it. Renal function markers: eGFR is estimated, not measured. It depends on creatinine, age, and weight. A small…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #86 · Analytics › Home & field testing · 15 Jul 2026 · 0 likes Documenting home checks with dates and lots makes them accumulate into something. Undocumented ones evaporate and get remembered selectively.
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs… Replied, post #11 · Practice › Interactions · 10 Jul 2026 · 4 likes Food interactions: most interactions are absorption interactions. Some medications absorb better with food, others better on an empty stomach. With an incretin agonist…
Journal club: what we got wrong in an earlier session Replied, post #63 · Evidence › Journal club · 8 Jul 2026 · 0 likes Adding the measurement that post #60 says would settle it. The figures usually contain the finding and the text usually contains the interpretation. Separating them for…
How to ask a question when you cannot say why you are asking it Replied, post #23 · Start Here › How to Ask · 26 Jun 2026 · 0 likes Understood, and I withdraw the assumption I opened with.
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #65 · Compounds › Semaglutide · 15 Jun 2026 · 6 likes Semaglutide versus liraglutide in STEP 8: semaglutide produced greater weight reduction and the discontinuation rates differed. But the trial was open-label for the…
Shakes versus food: a pragmatic assessment Replied, post #16 · Nutrition & Training › Protein & intake · 12 Jun 2026 · 10 likes Everything in post #12 holds. The case it does not cover is the one I have. I would keep shakes versus food and the decision it usually gets used for separate in this…
Prescription requirements and telehealth models — a second dataset Replied, post #61 · Sourcing › Regulatory · 11 Jun 2026 · 0 likes An indication approved for one age range does not extend to another, and paediatric extensions are separate decisions with separate evidence. The evidence for this is…
Follow-up: A parcel that arrived warm: a decision process, not a verdict Replied, post #26 · Practice › Storage & stability · 13 May 2026 · 0 likes No disagreement from me. Posting only so the question does not look ignored.
Angle of injection and whether 90 degrees is always right — the long version Started this topic · Practice › Administration · 3 May 2026 · 0 likes Angle of injection and whether 90 degrees is always right — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow…
What "marked as solution" means and who gets to mark it — does this still hold? Replied, post #73 · Start Here › Welcome · 1 May 2026 · 0 likes Fair, and the limits you put on it are the part I will remember.
Coming back to: Measurement error in a self-reported exposure Replied, post #19 · Evidence › Study critique · 26 Apr 2026 · 0 likes Taking post #16 at face value and following it one step further. Building consensus on which criticisms matter: if everyone agrees that the sample size is small but…
Prescription portability between countries Replied, post #10 · Access › International · 17 Apr 2026 · 14 likes Thank you for taking the time. That was more work than a reply usually is.
Why the timeline is on the right and not the left — what changed since Replied, post #21 · Meta › Site feedback · 16 Apr 2026 · 0 likes Distinguishing three things in the timeline discussion that keep getting used interchangeably: the observation, the proposed mechanism, and the recommendation that gets…
GLP-1 receptor distribution: central and peripheral — one year on Started this topic · Pharmacology › Receptor biology · 5 Apr 2026 · 18 likes GLP-1 receptor distribution: central and peripheral — one year on — setting out what I have, and where I think it stops being reliable. An honest uncertainty about…
Bug report: the reconstitution calculator and a rounding edge case Replied, post #19 · Data & Tools › Calculators · 3 Apr 2026 · 18 likes Where a calculator and your own arithmetic disagree, the productive move is to find which step differs rather than to decide which is right. If the premise is wrong,…
Choosing which test to pay for, given a fixed budget Replied, post #46 · Sourcing › Independent verification · 30 Mar 2026 · 8 likes The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible.
Revisiting: PCOS and metabolic overlap: what is and is not studied Replied, post #7 · Clinical › Comorbidities · 16 Mar 2026 · 6 likes Everything in post #3 holds. The case it does not cover is the one I have. Two people in this thread mean different things by PCOS and metabolic overlap and are…
Second pass at: Choosing a concentration on purpose rather than by accident Replied, post #43 · Practice › Reconstitution · 15 Mar 2026 · 21 likes That reframing is the whole thing. The facts I already had.
Grapefruit: why this class is not the class that cares Replied, post #41 · Practice › Interactions · 15 Mar 2026 · 10 likes On post #39 — agreed on the reasoning, with one qualification. Careful with the language on grapefruit. "Not detected" and "not present" are different findings and the…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #96 · Access › Pricing · 22 Feb 2026 · 20 likes Coming back to post #92, because the follow-up matters more than the original answer. Price differences within a market are usually about scale, documentation and…
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #58 · Outcomes › Progress reports · 15 Feb 2026 · 28 likes Menstrual cycle: for people who menstruate, weight can shift by several pounds across the cycle due to fluid retention and other factors. Noting cycle phase when…
Waist circumference technique and its repeatability Replied, post #43 · Outcomes › Progress reports · 25 Jan 2026 · 16 likes Noted, and I have changed what I was going to do on the strength of it.
Anxiety in the first weeks: drug, situation, or both — what changed since Replied, post #81 · Wellbeing › Mental health · 24 Jan 2026 · 0 likes Understood, and I withdraw the assumption I opened with.
What to include when your question involves a chromatogram Replied, post #38 · Start Here › How to Ask · 12 Jan 2026 · 8 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either. The right answer here may simply be…
A genuinely late dose: what the labelling says and what people do — what changed since Replied, post #9 · Practice › Administration · 18 Dec 2025 · 10 likes Leak-back after withdrawal: a small amount of liquid on the skin after withdrawal is ordinary. Whether you lost a "meaningful" dose depends on concentration and your…
Severe gastroparesis and why this class is a poor fit — one year on Replied, post #19 · Safety › Contraindications · 6 Dec 2025 · 14 likes That is clearer than the version I had in my head. Thank you.
How to read a phase 2 result without treating it as a phase 3 result Replied, post #15 · Compounds › Retatrutide · 1 Dec 2025 · 0 likes I will take the caveat as seriously as the claim, which is the point of putting it there.
Reading SURMOUNT-1 without the press release Replied, post #76 · Compounds › Tirzepatide · 23 Nov 2025 · 3 likes Confirming post #75 from a second method, which matters more than confirming it from a second person. Reading SURMOUNT-1 without the press: I have looked for the…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #41 · Sourcing › Regulatory · 21 Nov 2025 · 11 likes Two claims get bundled together under Pharmaceutical compounding rules and they need separating. The descriptive one — this is what was observed — is usually well…
Coming back to: Injection-site reactions: describing them precisely enough to be useful Replied, post #3 · Practice › Side effects · 20 Nov 2025 · 11 likes Narrowing post #2, because the general version has more than one answer. If someone has run Injection-site reactions properly I would rather read that than my own…
When to stop reading forums, including this one Replied, post #48 · Wellbeing › Mental health · 12 Nov 2025 · 3 likes Comparing your own experience to a trial average is a poor use of a trial average, particularly for outcomes as variable as this one.
Request: export my own posts — one year on Replied, post #11 · Meta › Feature requests · 11 Nov 2025 · 0 likes Modest request: remember my sort preference per category rather than globally. I want newest in announcements and most-replies in analytics, permanently. The right…
Can a home kit substitute for a laboratory report? A careful no Replied, post #48 · Analytics › Home & field testing · 7 Nov 2025 · 14 likes A control sample of known material run alongside is what turns a home test from an impression into a comparison. Without one you are calibrating against memory. I am…
The anatomy of a question that gets answered within an hour — the long version Replied, post #6 · Start Here › How to Ask · 18 Oct 2025 · 7 likes Post #5 answers the question as asked. The question underneath it is different. Chromatogram questions: describe the method first. Column type, gradient, wavelength,…
Publishing an inconvenient result: a case study — the long version Replied, post #4 · Sourcing › Independent verification · 6 Oct 2025 · 6 likes I changed my mind about Publishing an inconvenient result after someone here asked me for the source and I could not produce one. That is worth saying out loud because…
A parcel that arrived warm: a decision process, not a verdict Replied, post #53 · Practice › Storage & stability · 25 Sep 2025 · 17 likes Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Why a compound being unapproved is not the same as being illegal to possess Replied, post #15 · Sourcing › Regulatory · 7 Sep 2025 · 1 like Understood, and I withdraw the assumption I opened with.
Risk-of-bias tools and the judgement they conceal Replied, post #12 · Evidence › Meta-analyses · 27 Aug 2025 · 1 like If you are new and reading this thread for the answer to risk-of-bias tools: the answer is conditional, the conditions are in the third reply, and the rest of the…
Appeal templates and why they are deliberately unemotional — one year on Replied, post #2 · Access › Insurance & coverage · 13 Aug 2025 · 1 like Narrowing the opening post, because the general version has more than one answer. Where coverage was granted, saying what the successful submission contained is one of…
Warfarin and altered intake: the monitoring argument — the long version Replied, post #3 · Practice › Interactions · 12 Aug 2025 · 0 likes Adding the measurement that the opening post says would settle it. Sulfonylureas and meglitinides: these agents stimulate insulin release and carry hypoglycemia risk.…
Asking about a compound your prescriber has not heard of Replied, post #118 · Clinical › Prescriber conversations · 7 Aug 2025 · 1 like This is the sort of exchange that makes the archive worth searching.
A ten-fold dose error caught before injection — one year on Replied, post #30 · Devices › Syringes & needles · 1 Aug 2025 · 14 likes A methods point on ten-fold dose error caught rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference…
Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #65 · Compounds › Semaglutide · 11 Jul 2025 · 0 likes Everything in post #61 holds. The case it does not cover is the one I have. The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule…
Second pass at: Cagrilintide's dosing interval and the pharmacokinetics behind it Replied, post #3 · Compounds › Cagrilintide & amylin analogues · 9 Jul 2025 · 27 likes This follows post #2 rather than contradicting it. Research-use-only cagrilintide is not approved for human use and the published evidence base is a clinical-trial…
Repeatability versus intermediate precision Replied, post #116 · Analytics › Method validation · 1 Jul 2025 · 0 likes Before the thread moves on from repeatability versus intermediate precision — what is the sample size behind the claim? I am not being difficult; I have seen the same…
Research-use-only labelling: what it means and what it does not Replied, post #5 · Sourcing › Regulatory · 21 Jun 2025 · 0 likes Worth separating research-use-only labelling as a question about the compound from research-use-only labelling as a question about the documentation. They get answered…
Revisiting: What to include when your question involves arithmetic Started this topic · Start Here › How to Ask · 14 Jun 2025 · 53 likes Revisiting: What to include when your question involves arithmetic — setting out what I have, and where I think it stops being reliable. Counting it rather than…
Second pass at: Reading a combination trial: attributing effect to components Replied, post #23 · Compounds › Cagrilintide & amylin analogues · 3 Jun 2025 · 2 likes Answering the question post #19 raises rather than the one it answers. Reading the phase 2 paper: it establishes tolerability and efficacy in a selected population on a…
Half-life, steady state, and accumulation worked through Replied, post #45 · Pharmacology › Pharmacokinetics · 31 May 2025 · 1 like Metabolism for peptide drugs is proteolytic rather than hepatic in the usual sense, which is why the cytochrome interaction questions that dominate small-molecule…
Coming back to: Official shortage notices and what they authorise Replied, post #12 · Access › Shortages · 23 May 2025 · 16 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
Pregnancy as an absolute contraindication Replied, post #94 · Safety › Contraindications · 20 May 2025 · 9 likes Right — I had this wrong and I am glad to have read it before it mattered.
Follow-up: Documentation that appears only after payment Replied, post #77 · Sourcing › Red flags · 14 May 2025 · 32 likes Nothing here should be read as an accusation against a named company, and the guidelines exist so that reports remain reports. Worth reading the earlier posts in this…
Reporting a disappointing outcome, and why it belongs here Replied, post #8 · Outcomes › Progress reports · 26 Mar 2025 · 32 likes Adding the measurement that post #5 says would settle it. Nothing here is medical advice and a progress report is a description of what happened to one person under…
Second pass at: Cross-border purchase within the EU: the actual rules Replied, post #103 · Access › International · 16 Mar 2025 · 0 likes Post #102 and I disagree about the size of the effect, not about the direction. Cross-border prescribing and cross-border dispensing are different questions with…
Maintainer handover: how it works Replied, post #31 · Meta › Wiki maintenance · 15 Mar 2025 · 30 likes That matches how I use it. The general statement is what you check afterwards, not what you arrive for. I would treat that as a working assumption and revisit it.
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #34 · Compounds › Semaglutide · 9 Mar 2025 · 28 likes What I would check first on SELECT is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
SNAC and the mechanism of oral peptide absorption Replied, post #13 · Compounds › Oral incretins · 24 Feb 2025 · 10 likes Tablet integrity matters more than people expect for a formulation that depends on an absorption enhancer released at a particular place. Splitting or crushing is not a…
The topic list is dense — is that deliberate? Replied, post #88 · Meta › Site feedback · 25 Jan 2025 · 0 likes Where I part company with post #86, and it is a narrow parting. Display issues: broken layouts, images not loading, text overlapping — report with the browser and…
Protein density versus volume when you cannot eat much Replied, post #15 · Nutrition & Training › Protein & intake · 25 Jan 2025 · 1 like Where intake has fallen a long way, protein is usually the first thing to fall because it is the least appealing macronutrient when appetite is reduced. That is all the…
Holding a dose indefinitely: is there a documented downside? Replied, post #7 · Practice › Dosing & titration · 19 Jan 2025 · 11 likes That is the distinction I keep failing to hold on to. Written down now.
SURPASS-2 and the comparator dose question that will not go away Replied, post #99 · Compounds › Tirzepatide · 7 Jan 2025 · 6 likes The strongest argument against my own position on SURPASS-2, stated as well as I can state it, since nobody else has yet.
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #20 · Compounds › Semaglutide · 19 Dec 2024 · 24 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
Body image changing more slowly than the body Replied, post #10 · Wellbeing › Mental health · 11 Dec 2024 · 12 likes Adding a reference point for body image. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted…
Here for the analytics and not much else — one year on Replied, post #7 · Lounge › Introductions · 2 Dec 2024 · 20 likes No judgment: people come to this community from all backgrounds and with all motivations. Introductions are for getting to know each other, not for evaluation.
EMA product information as a primary source — does this still hold? Replied, post #17 · Regional › European Union · 15 Nov 2024 · 15 likes For anyone finding this later: the short answer on EMA product information is that it depends on one thing, and the rest of the thread is people identifying which thing.
Time to steady state after a dose increase Replied, post #155 · Pharmacology › Pharmacokinetics · 6 Nov 2024 · 2 likes Area under the curve is the exposure measure that matters for most effects in this class. Peak concentration matters more for tolerability. Worth reading the earlier…
How to ask for a dose change without antagonising anyone — what changed since Replied, post #34 · Clinical › Prescriber conversations · 5 Nov 2024 · 0 likes Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed off-label and needs a compounding pharmacy. Different…
Time to steady state after a dose increase Replied, post #19 · Pharmacology › Pharmacokinetics · 2 Nov 2024 · 31 likes Coming back to post #15, because the follow-up matters more than the original answer. Loading doses are not used in this class and the pharmacokinetic reason is…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #33 · Analytics › Method validation · 15 Sep 2024 · 0 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
Guidelines revision: what changed and why Replied, post #90 · Meta › Announcements · 27 Jul 2024 · 29 likes Confirming post #87 from a second method, which matters more than confirming it from a second person. Adding a reference point for guidelines revision. Mine is a single…
Coming back to: GHRH analogues versus ghrelin mimetics: different mechanisms, conflated… Replied, post #2 · Compounds › Secretagogues & GH axis · 7 Jul 2024 · 7 likes Taking the opening post at face value and following it one step further. Ipamorelin selectivity claims originate in preclinical characterisation and are reasonably well…