e.kimani

TL2 · Funchal

Contributes reviews on supplier material. Based in Funchal.

Joined 27 January 2025 · last posted 2d

89 posts, newest first. Showing up to 150.

[2026 update] A report I filed that turned out to be wrong, and the correction Replied, post #20 · Sourcing › Vendor reports · 26 Jul 2026 · 8 likes The maintainers will ask for missing fields rather than rejecting a report. Filling them in afterwards is normal and nobody minds. The evidence for this is thinner than…
Coming back to: Telehealth prescribing models in the US Replied, post #28 · Regional › North America · 25 Jul 2026 · 22 likes The public assessment documents published at approval are free, detailed and largely unread here. Anyone with a larger sample, please post it.
Journal club: what we got wrong in an earlier session Replied, post #111 · Evidence › Journal club · 23 Jul 2026 · 0 likes The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping. It…
Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #39 · Practice › Dosing & titration · 21 Jul 2026 · 0 likes Answering the question post #35 raises rather than the one it answers. Two people in this thread mean different things by four-week escalation interval and are…
Journal club: SUSTAIN 6 and its retinopathy signal Replied, post #89 · Evidence › Journal club · 20 Jul 2026 · 28 likes The figures usually contain the finding and the text usually contains the interpretation. Separating them for the first twenty minutes is a discipline worth keeping.…
NHS criteria and how they are applied in practice Replied, post #34 · Regional › UK & Ireland · 18 Jul 2026 · 0 likes Pharmacy practice varies between pharmacies and is not deducible from the regulatory position. Two people can honestly report opposite experiences. On balance I think…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #137 · Sourcing › Logistics · 17 Jul 2026 · 17 likes Document outcomes rather than forecasting them. A forecast in this category reads as reassurance and is not one. Noting that I have skin in this question and have tried…
Micro-titration: a disputed topic, argued properly — one year on Replied, post #63 · Practice › Dosing & titration · 14 Jul 2026 · 23 likes On Micro-titration I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how…
Here for the analytics and not much else Replied, post #27 · Lounge › Introductions · 13 Jul 2026 · 16 likes I had read the opposite somewhere and cannot now find where, which tells me something.
Risk-of-bias tools and the judgement they conceal — does this still hold? Replied, post #22 · Evidence › Meta-analyses · 3 Jul 2026 · 2 likes On Risk-of-bias tools, I would rather understate and be corrected upward than overstate and be quoted. That is a house style here and it is a good one.
Historical amylin analogues and what happened to them Replied, post #26 · Compounds › Cagrilintide & amylin analogues · 1 Jul 2026 · 0 likes Agreed, and I will stop repeating the version of this I had been repeating.
I have no scientific background — can I still follow the analytics categories? Replied, post #29 · Start Here › Welcome · 29 Jun 2026 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Pooling trials with different estimands Replied, post #57 · Evidence › Meta-analyses · 29 Jun 2026 · 3 likes Small methodological point on pooling trials with different estimands: repeating a measurement is cheap and resolves most of what is being argued about here at no cost…
GLP-1 receptor distribution: central and peripheral Replied, post #79 · Pharmacology › Receptor biology · 29 Jun 2026 · 1 like This is the answer, and the reason it is the answer is the more useful part.
Second pass at: Programming during a large energy deficit Replied, post #44 · Nutrition & Training › Resistance training · 25 Jun 2026 · 9 likes Programming during a large energy is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly.…
[2026 update] Area percent versus weight percent: the confusion that causes most arguments Replied, post #61 · Analytics › HPLC & UHPLC · 21 Jun 2026 · 0 likes Post #60 answers the question as asked. The question underneath it is different. What I can speak to on Area percent versus weight percent is narrow, so I will keep it…
Coming back to: Reconciling a supplier certificate with an independent result Replied, post #16 · Sourcing › Vendor reports · 19 Jun 2026 · 0 likes This follows post #14 rather than contradicting it. Pattern across lots: a single result is a data point. Three or four results from the same supplier showing a…
Follow-up: Search filters: what is missing Replied, post #133 · Meta › Site feedback · 19 Jun 2026 · 7 likes Narrowing post #131, because the general version has more than one answer. I keep a log for Search filters specifically because my memory of it turned out to be…
Pages past their review date, listed — does this still hold? Replied, post #7 · Meta › Wiki maintenance · 9 Jun 2026 · 23 likes Careful with that. A short duplicated paragraph is sometimes better than a link, because the reader who needs it is mid-task and will not follow a link. The test is…
Micronutrient adequacy at low total intake Replied, post #32 · Nutrition & Training › Protein & intake · 8 Jun 2026 · 2 likes I had written a reply contradicting post #28 and deleted it. Here is what survived. Eating anything at all: on substantial appetite suppression, eating enough total…
Angle of injection and whether 90 degrees is always right — the long version Replied, post #15 · Practice › Administration · 1 Jun 2026 · 16 likes The bit of Angle of injection that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #31 · Analytics › Home & field testing · 26 May 2026 · 11 likes Colorimetric tests: colour intensity correlates with concentration, but the relationship is non-linear at extremes and the correlation depends on the exact conditions…
Reflectance and photometric devices: precision in practice — a second dataset Replied, post #36 · Analytics › Home & field testing · 26 May 2026 · 11 likes Worth separating two things that post #33 runs together. The honest cost comparison is a home kit against a single independent submission. For most people the second…
Blind submission and why it changes minds — the long version Replied, post #75 · Sourcing › Independent verification · 14 May 2026 · 3 likes I read post #71 twice before replying, because I had assumed the opposite. The number people quote for Blind submission is a central estimate presented without its…
Common supplements people ask about, assessed one at a time — a second dataset Replied, post #96 · Practice › Interactions · 29 Apr 2026 · 2 likes The arithmetic in post #93 is right; the assumption feeding it is the part to check. Common supplements has a well-known answer and a correct answer, and the…
Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #5 · Compounds › Semaglutide · 26 Apr 2026 · 0 likes Post #3 put the caveat in the right place and I want to underline it. Albumin binding is not a unique structural feature and nothing in the class lacks it, but the…
Moderation log format change Replied, post #46 · Meta › Announcements · 20 Apr 2026 · 22 likes I read the earlier replies on moderation log format change twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with…
Bioimpedance and hydration: why the number moves Replied, post #33 · Outcomes › Body composition · 20 Apr 2026 · 20 likes One caution on bioimpedance and hydration: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is…
Pinch or no pinch, and how needle length changes the answer — what changed since Replied, post #15 · Practice › Administration · 14 Apr 2026 · 3 likes Useful. I had the fact and not the reason, which turns out to be the important half.
Batch numbers that do not match the vial label Replied, post #5 · Sourcing › Red flags · 12 Apr 2026 · 15 likes Agreed, and I will stop repeating the version of this I had been repeating.
CJC-1295 with and without DAC: what the modification does Replied, post #20 · Compounds › Secretagogues & GH axis · 26 Mar 2026 · 1 like A mass result for a short peptide is more discriminating than for a long one, because a single residue difference is a larger proportion of the total. That makes…
Measurement error in home scales, with a worked standard deviation Replied, post #18 · Research Methods › Statistics · 5 Mar 2026 · 25 likes Noted, and I have changed what I was going to do on the strength of it.
Revisiting: Language barriers in accessing a prescription abroad Replied, post #130 · Access › International · 25 Feb 2026 · 0 likes Post #127 is right about the mechanism and I think understates the practical bit. Language barriers: if you need to communicate with a supplier, clinician, or regulator…
Managing an unplanned gap in supply Replied, post #25 · Access › Shortages · 7 Feb 2026 · 15 likes Resuming after a gap: after a gap of days or a few weeks, most people resume at the dose they were on when they stopped. Gaps of months might require retitration…
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #21 · Analytics › Mass spectrometry · 29 Jan 2026 · 27 likes Taking post #20 at face value and following it one step further. The version of Adducts that circulates here is a simplification of a simplification. It is not wrong,…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #59 · Clinical › Bloodwork · 24 Jan 2026 · 3 likes Time of day: some biomarkers vary across the day. Cortisol in the morning differs from cortisol in the evening. Comparing results from different times of day is…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #13 · Practice › Storage & stability · 6 Jan 2026 · 0 likes Protecting from light: amber vials or opaque containers reduce light exposure. If you are storing for long periods and light matters, this is worth doing. For…
What to include when your question involves a chromatogram Replied, post #4 · Start Here › How to Ask · 26 Dec 2025 · 13 likes Adding thanks rather than a view. I do not have a view worth the space.
Coming back to: Private prescribing in the UK: what is actually involved Replied, post #15 · Regional › UK & Ireland · 26 Dec 2025 · 0 likes Post #14 answers the question as asked. The question underneath it is different. Correcting an out-of-date claim in this subcategory with a source and a date is more…
Temperature loggers worth the money — the long version Replied, post #94 · Devices › Cold chain · 16 Dec 2025 · 0 likes Fair, and the limits you put on it are the part I will remember.
Second pass at: Circumference measurements as a poor man's composition estimate Replied, post #12 · Outcomes › Body composition · 5 Nov 2025 · 4 likes No notes. Posting so the count is not one.
Managing an unplanned gap in supply — what changed since Replied, post #105 · Access › Shortages · 2 Nov 2025 · 25 likes Managing an unplanned gap: if a shortage causes a gap in treatment, the questions are how long the gap will be and how that affects your condition. Discussing with your…
Airline travel with a temperature-sensitive injectable Replied, post #11 · Devices › Cold chain · 29 Oct 2025 · 24 likes Shipment during summer or to hot climates: consider shipping to a cold-storage facility rather than to home if temperatures will be high. Alternatively, time shipment…
Non-inferiority margins: how they are chosen and how they are abused Replied, post #10 · Evidence › Trials · 29 Oct 2025 · 21 likes I read post #6 twice before replying, because I had assumed the opposite. A treatment-policy estimand asks what happens to people assigned to a strategy, including…
Request: a diff view for wiki revisions — the long version Replied, post #61 · Meta › Feature requests · 26 Oct 2025 · 22 likes Whatever the answer on diff view for wiki revisions turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, invite…
Where to report an adverse event officially, by region — a second dataset Replied, post #35 · Safety › Adverse events · 19 Oct 2025 · 0 likes No disagreement from me. Posting only so the question does not look ignored.
A 40-week log with the measurement method stated Replied, post #15 · Outcomes › Progress reports · 15 Oct 2025 · 0 likes I read post #11 twice before replying, because I had assumed the opposite. Measurement noise: day-to-day body mass varies by more than a kilogram on hydration,…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #20 · Start Here › Welcome · 13 Oct 2025 · 11 likes Reading back through, this was answered upthread and I missed it. My fault.
Availability by country, dated, with primary sources Replied, post #15 · Access › International · 9 Oct 2025 · 10 likes The version of availability that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
Follow-up: Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #8 · Practice › Dosing & titration · 4 Oct 2025 · 0 likes I had written a reply contradicting post #4 and deleted it. Here is what survived. Going back down a step is not a failure and the trials allowed it. Several protocols…
A comparison of home results against a laboratory result on the same vial Replied, post #42 · Analytics › Home & field testing · 27 Sep 2025 · 0 likes Immunoassay limitations: tests that use antibodies have cross-reactivity limitations. An antibody raised to semaglutide will cross-react to some degree with tirzepatide…
How the vendor documentation pages are maintained, and by whom — what changed since Replied, post #62 · Sourcing › Vendor reports · 25 Sep 2025 · 7 likes Coming back to post #58, because the follow-up matters more than the original answer. What would change my mind on vendor documentation pages is a second dataset…
Cross-border purchase rules within the EU Replied, post #14 · Regional › European Union · 21 Sep 2025 · 30 likes Correcting a stale claim here is more valuable than adding a new one, because the stale claims are what people find first.
High-resolution MS on aggregates and what it can see Replied, post #72 · Analytics › Mass spectrometry · 20 Sep 2025 · 11 likes The honest answer on high-resolution is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much they matter. Most…
A preprint whose numbers changed substantially at publication Replied, post #42 · Evidence › Preprints · 5 Sep 2025 · 18 likes Narrowing post #40, because the general version has more than one answer. Where a preprint's numbers are the basis of a claim being repeated here, someone should check…
Second pass at: What "verified" means on our vendor pages, stated narrowly Replied, post #12 · Sourcing › Vendor reports · 2 Sep 2025 · 1 like Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is water, counter-ion, and excipient. Purity and content are…
Freeze-thaw and why one cycle is not the same as five — a second dataset Replied, post #38 · Practice › Storage & stability · 28 Aug 2025 · 30 likes Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear. I would rather…
When a preprint is the best available evidence and we say so Replied, post #106 · Evidence › Preprints · 27 Aug 2025 · 11 likes Adding thanks rather than a view. I do not have a view worth the space.
Follow-up: The lowest dose that does anything: is that a real question? Replied, post #45 · Practice › Dosing & titration · 25 Aug 2025 · 4 likes A missed dose in a weekly schedule is not a trough to chase. With a week-long half-life you are perturbing a slowly moving average, and the labelling for licensed…
A ten-fold dose error caught before injection — one year on Replied, post #151 · Devices › Syringes & needles · 5 Aug 2025 · 4 likes The arithmetic in post #150 is right; the assumption feeding it is the part to check. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm…
[2026 update] Mood changes: monitoring, and when to involve a professional Replied, post #16 · Wellbeing › Mental health · 1 Aug 2025 · 7 likes Source for the Mood changes figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version circulating is stronger than the…
Managing an unplanned gap in supply — what changed since Replied, post #16 · Access › Shortages · 13 Jul 2025 · 2 likes Post #15 is right about the mechanism and I think understates the practical bit. Second-hand on Managing an unplanned gap, so weight it accordingly — someone whose…
About the Datasets category Replied, post #8 · Data & Tools › Datasets · 7 Jun 2025 · 30 likes Combining data from different sources: datasets from this site are not directly comparable to published trials because the populations are different. They are worth…
Second pass at: Pen dose counters: what a click does and does not guarantee Replied, post #59 · Devices › Pens & autoinjectors · 6 Jun 2025 · 11 likes Dose counters: pens show the remaining number of doses. When the counter reaches zero, the pen is empty and cannot deliver more. Noting the counter before injection…
Pre-registering a personal experiment, seriously Replied, post #101 · Research Methods › N-of-1 designs · 3 Jun 2025 · 6 likes Two questions I would want answered before drawing anything from the pre-registering a personal experiment data above: how were the cases selected, and what happened to…
How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ Replied, post #106 · Sourcing › Independent verification · 16 May 2025 · 0 likes The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible.
Pages past their review date, listed — does this still hold? Replied, post #25 · Meta › Wiki maintenance · 11 May 2025 · 14 likes Practical note on Pages past: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would allow.
Journal club: STEP 4 and what a withdrawal design can prove Replied, post #37 · Evidence › Journal club · 10 May 2025 · 4 likes Answering the question post #33 raises rather than the one it answers. A conflict-of-interest statement is worth reading aloud and is worth very little as a predictor.…
Reading a trial's population section before its results — does this still hold? Replied, post #34 · Evidence › Trials · 23 Apr 2025 · 0 likes Multiplicity and multiple comparisons: if a trial tests many hypotheses, the chance of a false positive on at least one by random chance increases. This is why…
Scheduled maintenance and what will be unavailable Replied, post #120 · Meta › Announcements · 23 Apr 2025 · 6 likes I have no financial interest in anything named in this thread and I want to say so before I comment on scheduled maintenance, because it is the sort of subject where it…
Checking someone else's arithmetic: a worked example thread Replied, post #40 · Practice › Reconstitution · 20 Apr 2025 · 6 likes On post #38 — agreed on the reasoning, with one qualification. Do not shake. Swirl, or leave it. Vigorous agitation introduces air and shear, and neither helps a…
Reading a rodent study on a secretagogue without over-extrapolating Started this topic · Compounds › Secretagogues & GH axis · 15 Apr 2025 · 37 likes Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. Reading a…
Validating a method you did not develop — does this still hold? Replied, post #109 · Analytics › Method validation · 13 Mar 2025 · 20 likes Sensible. I would want the same detail before I acted on it either.
A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #21 · Practice › Reconstitution · 10 Mar 2025 · 0 likes Where I part company with post #20, and it is a narrow parting. Concentration is total mass divided by total volume, and everything else follows from that. Ten…
Sample size in a voluntary survey: the selection problem Replied, post #5 · Data & Tools › Datasets · 10 Mar 2025 · 6 likes Units in the column header, always, and the same units down the whole column. Mixed units in one field is the commonest defect in shared spreadsheets here. A single…
Journal club: SURMOUNT-1, read without the press release Replied, post #65 · Evidence › Journal club · 22 Feb 2025 · 9 likes The version of SURMOUNT-1 that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
Telehealth prescribing models in the US Replied, post #56 · Regional › North America · 9 Feb 2025 · 26 likes Worth separating two things that post #53 runs together. I keep a log for telehealth prescribing models specifically because my memory of it turned out to be…
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Replied, post #88 · Evidence › Journal club · 10 Jan 2025 · 14 likes I would be cautious about generalising from the SURPASS-2 example above. It is a good example. It is one example.
What changed in 2026, by region Replied, post #31 · Access › International · 20 Dec 2024 · 20 likes Licensed prescribing: where a compound is approved, prescribing is restricted to licensed prescribers. Where it is not approved, the legality of possession and use is…
Persistent vomiting and the threshold for seeking help — one year on Replied, post #14 · Safety › Adverse events · 19 Dec 2024 · 2 likes The reason Persistent vomiting is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is…
Coming back to: When to suspect the method rather than the sample Replied, post #34 · Analytics › Method validation · 6 Dec 2024 · 0 likes Why two laboratories may disagree: after validating the same method, they may still report different purity on the same sample due to integration differences, column…
SNAC and the mechanism of oral peptide absorption — the long version Replied, post #12 · Compounds › Oral incretins · 22 Nov 2024 · 0 likes Orforglipron is a small molecule rather than a peptide, which changes almost everything about how it is made, stored and analysed. Comparing it to oral semaglutide as…
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #109 · Clinical › Bloodwork · 14 Oct 2024 · 0 likes One caution on bring a laboratory: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.
Requesting a page: what makes a good request — what changed since Replied, post #72 · Documentation › Wiki requests · 11 Oct 2024 · 26 likes Building on post #71 rather than restating it. A page that would need to be rewritten every quarter is usually better as a topic with a good marked solution. That is…
Follow-up: A site rotation scheme that is easy enough to actually follow Replied, post #77 · Practice › Administration · 4 Oct 2024 · 0 likes Acknowledging rather than arguing. The reasoning holds as far as I can follow it.
Irish differences from the UK position Replied, post #17 · Regional › UK & Ireland · 1 Oct 2024 · 4 likes Two questions I would want answered before drawing anything from the irish differences data above: how were the cases selected, and what happened to the ones that…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #67 · Analytics › COA interpretation · 27 Sep 2024 · 1 like Saving this. It is the version I will quote when the question comes round again.
Second pass at: Journal club: LEADER as the historical anchor Replied, post #53 · Evidence › Journal club · 22 Jul 2024 · 19 likes My understanding of LEADER is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it.
Journal club: FLOW and the renal composite, component by component Replied, post #32 · Evidence › Journal club · 11 Jul 2024 · 0 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. I keep a log of…