h.eriksen

TL2 · Osijek

Contributes reviews on supplier material. Based in Osijek.

Joined 15 November 2024 · last posted 10h

76 posts, newest first. Showing up to 150.

What a statistical analysis plan adds that the paper does not Replied, post #3 · marked as the solution · Evidence › Trials · 27 Jul 2026 · 7 likes Confirming the opening post from a second method, which matters more than confirming it from a second person. Dropout is information: high dropout rates can indicate…
Insurance and replacement policies, compared Replied, post #115 · Sourcing › Logistics · 24 Jul 2026 · 0 likes Where I have landed on insurance and replacement policies, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a…
[2026 update] Antibiotics and a course of something with delayed emptying Replied, post #83 · Practice › Interactions · 24 Jul 2026 · 0 likes Adding the measurement that post #82 says would settle it. Food interactions: most interactions are absorption interactions. Some medications absorb better with food,…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #58 · Pharmacology › Pharmacokinetics · 22 Jul 2026 · 13 likes Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5 half-lives (about 4 to 5 weeks). Before that,…
A single out-of-range value on an otherwise normal panel Replied, post #74 · Clinical › Bloodwork · 18 Jul 2026 · 8 likes A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line.
What to bring: records that a clinician can actually use — a second dataset Replied, post #15 · Clinical › Prescriber conversations · 7 Jul 2026 · 19 likes Confirming post #14 from a second method, which matters more than confirming it from a second person. Prescription logistics: confirm whether it will be filled locally,…
An appeal that succeeded, with the letter structure Replied, post #13 · Access › Insurance & coverage · 7 Jul 2026 · 21 likes Post #11 put the caveat in the right place and I want to underline it. Nothing here is legal or medical advice, and appeal processes differ enough by jurisdiction and…
Pooling trials with different estimands Replied, post #73 · Evidence › Meta-analyses · 5 Jul 2026 · 0 likes Everything in post #69 holds. The case it does not cover is the one I have. Fixed-effects versus random-effects models: fixed-effects assumes all studies are estimating…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #110 · Analytics › HPLC & UHPLC · 5 Jul 2026 · 24 likes The most useful thing anyone has posted about Carryover in this category was a table of what had been measured and by whom. That is what I would want again.
[2026 update] Interpreting a result that disagrees with the supplier's certificate Replied, post #62 · Sourcing › Independent verification · 3 Jul 2026 · 15 likes Answering the Interpreting a result question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how the…
Reference intervals: how they are constructed and why one in twenty flags — does this… Replied, post #9 · marked as the solution · Clinical › Bloodwork · 25 Jun 2026 · 7 likes Second-hand on Reference intervals, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.
An 18-month record including the parts that went badly Replied, post #37 · Outcomes › Progress reports · 10 Jun 2026 · 0 likes Medication changes: escalating dose, or adding or removing other medications, can affect the rate of weight loss. Documenting medication changes alongside weight makes…
Micro-titration: a disputed topic, argued properly — one year on Replied, post #47 · Practice › Dosing & titration · 9 Jun 2026 · 9 likes Micro-titration looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
Tracking a shortage from primary sources rather than rumour Replied, post #28 · Access › Shortages · 30 May 2026 · 0 likes A shortage of one presentation is not a shortage of all of them, and the published notices are specific about which.
Revisiting: The arithmetic of an intermediate dose between two label steps Replied, post #36 · Practice › Dosing & titration · 20 May 2026 · 19 likes Writing down the date, the dose and the site each week takes fifteen seconds and is the single most useful record anyone here keeps. Memory reconstructs a titration…
Batch numbers that do not match the vial label Replied, post #18 · Sourcing › Red flags · 19 May 2026 · 4 likes Summarising the batch numbers thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the correction to it, and the…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #40 · Devices › Syringes & needles · 14 May 2026 · 9 likes Barrel size determines resolution and nothing else. A 0.3 mL barrel and a 1 mL barrel deliver the same volume equally well; the smaller one lets you see what you are…
Vomiting: when it is expected and when it is a reason to stop — one year on Replied, post #8 · Practice › Side effects · 12 May 2026 · 1 like Nothing to add on the substance. Thank you for taking the question at face value.
A plateau that disappeared when I changed how I measured — the long version Replied, post #34 · Outcomes › Progress reports · 4 May 2026 · 0 likes A plateau over two weeks is usually measurement. A plateau over two months is usually energy balance. The timescale is what distinguishes them. I have changed my mind…
Tracking intake honestly when appetite is absent Replied, post #7 · Nutrition & Training › Protein & intake · 24 Apr 2026 · 14 likes Where intake has fallen a long way, protein is usually the first thing to fall because it is the least appealing macronutrient when appetite is reduced.
Spreadsheets: an appreciation — what changed since Replied, post #19 · Lounge › Off topic · 14 Apr 2026 · 0 likes Unserious but true: I can now identify a certificate template at a glance and I have no professional use for that skill whatsoever. One case, stated as one case.
Spike-and-recover accuracy for a peptide assay Replied, post #71 · Analytics › Method validation · 9 Apr 2026 · 0 likes The limit of quantitation determines what the impurity table can honestly contain. Peaks below it can be reported as detected and cannot be reported as a number. A…
Type 2 diabetes and the largest part of the evidence base Replied, post #61 · Clinical › Comorbidities · 9 Apr 2026 · 30 likes Where a condition is well controlled and where it is not are different questions and the published data rarely distinguishes them. Scoping that to what I have actually…
Run-in periods and the population they select Replied, post #96 · Evidence › Trials · 9 Apr 2026 · 0 likes Taking post #95 at face value and following it one step further. Absolute and relative effects answer different questions. Write down the event rate in each arm and the…
Coming back to: Washout: how long is long enough, and for what purpose Replied, post #97 · Pharmacology › Pharmacokinetics · 7 Apr 2026 · 0 likes Post #93 describes the usual case. This is about the unusual one. Where two sources give different half-lives, check the study design before deciding either is wrong.…
Follow-up: State-level differences that actually matter Replied, post #29 · Regional › North America · 5 Apr 2026 · 19 likes Everything in post #27 holds. The case it does not cover is the one I have. Distinguishing three things in the State-level differences discussion that keep getting used…
Labelling requirements for research chemicals Replied, post #7 · Sourcing › Regulatory · 2 Apr 2026 · 13 likes Labelling requirements for research chemicals has been discussed here with more heat than it deserves, mostly because two definitions have been in play the whole time.
[2026 update] Composite endpoints and the component doing the work Replied, post #33 · Evidence › Trials · 16 Mar 2026 · 0 likes A treatment-policy estimand asks what happens to people assigned to a strategy, including those who abandon it. A hypothetical estimand asks what would have happened…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #14 · Evidence › Journal club · 11 Mar 2026 · 31 likes Coming back to post #12, because the follow-up matters more than the original answer. A methods point on orforglipron phase 2 rather than a substantive one: if the…
[2026 update] Publication patterns in the BPC-157 literature, examined Replied, post #14 · Compounds › Repair & healing peptides · 4 Mar 2026 · 7 likes Worth separating two things that post #12 runs together. Publication patterns is a good example of a question where the honest answer is boring and the interesting…
[2026 update] Thyroid function tests during substantial weight change Replied, post #8 · Clinical › Bloodwork · 4 Mar 2026 · 31 likes Thyroid function tests during substantial is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in…
The lowest dose that does anything: is that a real question? Replied, post #22 · Practice › Dosing & titration · 2 Mar 2026 · 0 likes Post #18 and I disagree about the size of the effect, not about the direction. When a dose reduction is the correct response to a side effect: if a side effect is…
Measurement error in a self-reported exposure Replied, post #43 · Evidence › Study critique · 24 Feb 2026 · 12 likes Narrowing post #41, because the general version has more than one answer. The practical version of measurement error is three sentences long. The rigorous version is…
Follow-up: Search filters: what is missing Replied, post #39 · Meta › Site feedback · 23 Feb 2026 · 5 likes One more thing on Search filters that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the apparent…
Revisiting: Language barriers in accessing a prescription abroad Replied, post #76 · Access › International · 27 Jan 2026 · 9 likes Post #75 is the version of this I will quote in future. One addition. Trying to state the Language barriers in accessing position in a way that someone who disagrees…
Coming back to: Training through a dose escalation week Replied, post #15 · Nutrition & Training › Resistance training · 25 Jan 2026 · 1 like Training through a dose escalation would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
Muscle cramps: the ordinary causes before the exotic ones Replied, post #70 · Practice › Side effects · 19 Jan 2026 · 20 likes Fatigue: commonly reported, frequently multifactorial. It is worth asking whether other factors have changed (sleep, training volume, diet adequacy, hydration) before…
Charge states for a 4 kDa peptide, worked through — the long version Started this topic · Analytics › Mass spectrometry · 16 Jan 2026 · 4 likes Charge states for a 4 kDa peptide, worked through — the long version Writing it up because I had to work it out twice and would rather nobody else did. Working through…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #9 · Data & Tools › Datasets · 28 Dec 2025 · 10 likes Version the file rather than editing in place. A dataset that changes silently under an analysis makes the analysis unreproducible. If it helps: the failure mode here…
Non-inferiority margins: how they are chosen and how they are abused Replied, post #21 · Evidence › Trials · 5 Dec 2025 · 18 likes Adding the measurement that post #18 says would settle it. An honest declaration on non-inferiority margins: I have a prior here and it is strong enough that you should…
Follow-up: Constipation management, with a dietitian's contribution Replied, post #25 · Practice › Side effects · 14 Nov 2025 · 5 likes The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #10 · Clinical › Bloodwork · 13 Nov 2025 · 8 likes The second most useful thing it does is say clearly when the answer is to book the appointment.
Bleeding at the injection site: normal, and what to do about it Replied, post #3 · marked as the solution · Practice › Administration · 2 Nov 2025 · 7 likes On the opening post — agreed on the reasoning, with one qualification. Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It is not…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #21 · Compounds › Oral incretins · 28 Oct 2025 · 10 likes Coming back to post #17, because the follow-up matters more than the original answer. PIONEER programme is phase 3 for oral semaglutide. The trials cover multiple…
Request: a diff view for wiki revisions — the long version Replied, post #41 · Meta › Feature requests · 10 Sep 2025 · 9 likes Practical experience of diff view for wiki revisions, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what…
Liver enzymes drifting down and what that usually means Replied, post #10 · Clinical › Bloodwork · 9 Sep 2025 · 10 likes Repeat before acting is standard practice for an isolated abnormal result on most analytes, and it is standard for a reason. On balance I think that is right, and I…
When a preprint is the best available evidence and we say so Replied, post #126 · Evidence › Preprints · 1 Sep 2025 · 2 likes Version numbers on a preprint server matter. Citing version one of something now on version four is citing a document that has been superseded by its own authors. The…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #115 · Compounds › Secretagogues & GH axis · 30 Aug 2025 · 4 likes This is the answer, and the reason it is the answer is the more useful part.
Substitution between formats during a shortage Replied, post #37 · Access › Shortages · 11 Aug 2025 · 11 likes Post #33 put the caveat in the right place and I want to underline it. Something worth flagging about substitution between formats: the strongest-sounding claims in…
High-resolution MS on aggregates and what it can see Replied, post #41 · Analytics › Mass spectrometry · 10 Aug 2025 · 15 likes Mass accuracy is expressed in parts per million. It is the difference between observed and theoretical mass divided by theoretical mass, multiplied by a million. A…
Antibiotics and a course of something with delayed emptying Replied, post #106 · Practice › Interactions · 1 Aug 2025 · 0 likes Everything in post #104 holds. The case it does not cover is the one I have. SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular…
Criticising the method without criticising the authors — one year on Replied, post #13 · Evidence › Study critique · 24 Jul 2025 · 10 likes Attrition is the failure mode most likely to invalidate a result and the least likely to be discussed. Differential attrition between arms is the specific thing to look…
Managing an unplanned gap in supply — what changed since Replied, post #22 · Access › Shortages · 22 Jul 2025 · 3 likes Post #20 and I disagree about the size of the effect, not about the direction. Where a manufacturer publishes a supply statement, that document is more reliable than…
Journal club: indirect comparison between two programmes, defended and attacked — one… Replied, post #19 · Evidence › Journal club · 6 Jul 2025 · 21 likes Post #18 describes the usual case. This is about the unusual one. An hour is enough for one paper read properly and not enough for two read partly. The temptation is…
Reporting a disappointing outcome, and why it belongs here Replied, post #19 · Outcomes › Progress reports · 3 Jul 2025 · 33 likes Maintenance series are the ones this subcategory needs most and receives least. The interesting questions all change once loss stops. A single observation, in a thread…
Micronutrient status when intake falls substantially Replied, post #14 · Clinical › Bloodwork · 1 Jul 2025 · 7 likes Narrowing post #11, because the general version has more than one answer. Worth stating the null on micronutrient status before we explain it: the observation may be…
Specification in the result column: why that is a meaningful error Replied, post #13 · Analytics › COA interpretation · 28 Jun 2025 · 1 like Method identification means enough to reproduce: column chemistry, dimensions, gradient, flow, wavelength. A method name alone identifies a family of methods.
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #9 · Compounds › Semaglutide · 1 Jun 2025 · 23 likes A note on how semaglutide versus liraglutide gets discussed rather than on semaglutide versus liraglutide itself: the confident posts get the replies and the careful…
Coming back to: What published stability data actually covers, and what it does not Replied, post #35 · Practice › Storage & stability · 6 May 2025 · 0 likes Adding the measurement that post #34 says would settle it. Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to…
Certificates issued by the seller versus by a laboratory Replied, post #63 · Analytics › COA interpretation · 26 Apr 2025 · 4 likes Marking my place. If it changes for me I will come back and say so.
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Replied, post #8 · Evidence › Journal club · 8 Apr 2025 · 0 likes STEP 4 was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.
A ten-fold dose error caught before injection Replied, post #14 · Devices › Syringes & needles · 28 Mar 2025 · 5 likes Post #10 put the caveat in the right place and I want to underline it. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or…
A promotion I argued against, and why I lost Replied, post #121 · Documentation › Doc review · 5 Mar 2025 · 2 likes Where I part company with post #119, and it is a narrow parting. Objections are genuinely wanted at this stage, because a bad promotion is much harder to undo than a…
Pancreatitis history and the risk calculus — a second dataset Replied, post #25 · Safety › Contraindications · 27 Feb 2025 · 0 likes I had read the opposite somewhere and cannot now find where, which tells me something.
Identical chromatograms across two different lots Replied, post #88 · Sourcing › Red flags · 8 Feb 2025 · 0 likes Narrowing post #87, because the general version has more than one answer. Two things can be true about identical chromatograms at once: the mechanism is plausible and…
Escalating every six weeks instead of four: what I observed over eight months Replied, post #4 · Practice › Dosing & titration · 1 Jan 2025 · 5 likes How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a particular cadence; the SURPASS and SURMOUNT programmes used…
Fixed versus detachable needles: the trade-offs Replied, post #76 · Devices › Syringes & needles · 28 Dec 2024 · 4 likes Adding the measurement that post #75 says would settle it. If someone has run fixed versus detachable needles properly I would rather read that than my own…
Washout with a one-week half-life: the arithmetic Replied, post #68 · Research Methods › N-of-1 designs · 5 Dec 2024 · 1 like Generalisability: a robust n-of-1 result applies to you. It does not tell you much about whether the effect generalises to others similar to you, much less to people…
Second pass at: Food noise reducing and the disorientation that can follow Replied, post #57 · Wellbeing › Mental health · 29 Oct 2024 · 0 likes Motivation and expectation: starting with clear motivation and realistic expectations about what will happen and when helps with psychological adjustment. The confident…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #47 · Clinical › Comorbidities · 17 Oct 2024 · 24 likes My understanding of Hypertension improvement is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating…
Second pass at: Sodium, potassium and magnesium when intake drops Replied, post #63 · Nutrition & Training › Hydration & electrolytes · 28 Aug 2024 · 8 likes Magnesium: deficiency during weight loss is common and symptoms (fatigue, muscle cramps) are nonspecific. Supplementation is inexpensive and low-risk if needed.
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #2 · Analytics › Method validation · 12 Jul 2024 · 1 like An independent laboratory's method being different from the supplier's is not a discrepancy. It becomes one only when the results differ by more than both methods'…
Journal club: FLOW and the renal composite, component by component Replied, post #4 · Evidence › Journal club · 7 Jul 2024 · 21 likes Sessions on negative or null results are consistently the most instructive and the hardest to get anyone to attend. I would rather say I do not know than round it up to…
Splitting a weekly dose in two: the pharmacokinetic argument against — the long version Replied, post #27 · Practice › Dosing & titration · 7 Jul 2024 · 26 likes Dose and effect are not linear across the studied range for every compound in this class. Assuming a doubled dose gives a doubled effect is the reasoning error behind…
The mass-error checker and its intended scope Replied, post #85 · Data & Tools › Calculators · 29 Jun 2024 · 0 likes Practical experience of mass-error checker, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it…
Assessing a warm arrival: the decision process — one year on Replied, post #6 · Sourcing › Logistics · 28 May 2024 · 6 likes Post #5 is right about the mechanism and I think understates the practical bit. Anyone deciding whether a delay is a problem should ask what would change if they waited…