p.krastev

TL2 · Lyon

Contributes reviews on supplier material. Based in Lyon.

Joined 6 April 2025 · last posted 8d

104 posts, newest first. Showing up to 150.

How shortages have affected compounding permissions Replied, post #55 · Access › Shortages · 20 Jul 2026 · 6 likes Shortage predictions: regulators and suppliers issue shortage alerts before they become acute. Checking the regulatory website for shortages gives you advance notice.…
Immortal time bias in a claims-database study — one year on Replied, post #33 · Evidence › Study critique · 20 Jul 2026 · 21 likes Answering the question post #32 raises rather than the one it answers. Checked the Immortal time bias claim against the primary source this morning. It survives, with a…
Deletion sequences: expected mass shifts by residue — the long version Replied, post #17 · Analytics › Impurities & related substances · 20 Jul 2026 · 10 likes Aggregates may be a multiple of the monomer mass and may not elute at all under a standard method. What does not come off the column does not appear in the area…
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #70 · Evidence › Journal club · 19 Jul 2026 · 30 likes Where the group cannot agree, record the disagreement rather than resolving it by seniority. The recorded disagreement is more honest and more useful later. Speaking…
[2026 update] Journal club: what we got wrong in an earlier session Replied, post #6 · Evidence › Journal club · 10 Jul 2026 · 12 likes Post #4 is the version of this I will quote in future. One addition. The baseline characteristics table is the single most useful page for the questions that get asked…
Revisiting: What pooling buys you and what it destroys Replied, post #53 · Evidence › Meta-analyses · 13 Jun 2026 · 6 likes Posting my pooling buys numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular…
GLP-1 receptor distribution: central and peripheral Replied, post #61 · Pharmacology › Receptor biology · 2 Jun 2026 · 0 likes Glucagon receptor agonism raises energy expenditure and promotes hepatic fat oxidation. In a triple agonist the incretin limbs offset the glycaemic consequence, which…
Historical amylin analogues and what happened to them Replied, post #14 · Compounds › Cagrilintide & amylin analogues · 1 Jun 2026 · 0 likes The arithmetic on historical amylin analogues is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will…
Follow-up: Comparing two chromatograms from different laboratories, properly Replied, post #34 · Analytics › HPLC & UHPLC · 29 May 2026 · 19 likes Clear enough that I do not think I have a follow-up, which is unusual.
Tracking intake honestly when appetite is absent Replied, post #40 · Nutrition & Training › Protein & intake · 28 May 2026 · 0 likes The arithmetic in post #37 is right; the assumption feeding it is the part to check. Before the thread moves on from tracking intake — what is the sample size behind…
Coming back to: Lateral-flow and colorimetric approaches: the specificity problem Replied, post #29 · Analytics › Home & field testing · 24 May 2026 · 32 likes Building on post #28 rather than restating it. An update on my earlier Lateral-flow and colorimetric approaches post: the pattern held for another six weeks and then…
An 18-month record including the parts that went badly Replied, post #19 · Outcomes › Progress reports · 18 May 2026 · 0 likes If someone has run 18-month record properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.
Spreadsheets: an appreciation — what changed since Replied, post #45 · Lounge › Off topic · 17 May 2026 · 23 likes Humour: light, relevant humour is welcome. Cruel humour targeting individuals or groups is not. Reading it again, the caveat matters more than the finding.
The most useful thing you learned here that was not the answer you came for Replied, post #40 · Lounge › Off topic · 6 May 2026 · 1 like Adjacent and interesting: you might post something about nutrition, bioavailability from a food perspective, or the sociology of weight. Adjacent to this community's…
Revisiting: A field-by-field walk through a certificate of analysis Replied, post #5 · Analytics › COA interpretation · 28 Apr 2026 · 3 likes Everything in the opening post holds. The case it does not cover is the one I have. The distinction between release testing and characterisation is one industrial…
Revisiting: Liver enzymes drifting down and what that usually means Replied, post #24 · Clinical › Bloodwork · 22 Apr 2026 · 11 likes Answering the question post #22 raises rather than the one it answers. Sample handling before analysis affects several analytes, and a haemolysed sample produces…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #18 · Devices › Syringes & needles · 18 Apr 2026 · 0 likes One more thing on 0.3 ml versus 0.5 ml that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the…
A widely repeated interaction claim that turns out to be unsupported Replied, post #43 · Practice › Interactions · 6 Apr 2026 · 0 likes Alcohol is not contraindicated in the labelling and it does irritate a stomach that is already emptying slowly. There is no published interaction study, and the…
Why the titration planner refuses to produce a schedule below a floor Replied, post #56 · Data & Tools › Calculators · 1 Apr 2026 · 10 likes Building on post #55 rather than restating it. Significant figures in the output should not exceed what the inputs support. A concentration calculated from a nominal…
Grapefruit: why this class is not the class that cares Replied, post #90 · Practice › Interactions · 28 Mar 2026 · 13 likes I would put moderate confidence on the mainstream reading of grapefruit and no more. That is not scepticism for its own sake; it is where the sourcing actually stops.
Pinch or no pinch, and how needle length changes the answer — the long version Replied, post #35 · Practice › Administration · 24 Mar 2026 · 8 likes I had written a reply contradicting post #33 and deleted it. Here is what survived. If you have to inject at a different time of day than usual, that is a much smaller…
Trust level 3 requirements: a clarification — does this still hold? Replied, post #17 · Meta › Announcements · 16 Mar 2026 · 10 likes Worth separating two things that post #15 runs together. Questions welcomed: if an announcement is unclear, asking for clarification is welcome. Staff will explain…
Reading a preclinical wound-healing model and its relevance to a human tendon — a second… Replied, post #13 · Compounds › Repair & healing peptides · 8 Mar 2026 · 2 likes Taking post #12 at face value and following it one step further. I have been on both sides of the Reading a preclinical wound-healing model argument in this category…
Coming back to: Time to steady state after a dose increase Replied, post #9 · Pharmacology › Pharmacokinetics · 4 Mar 2026 · 1 like Answering the question post #5 raises rather than the one it answers. Where two sources give different half-lives, check the study design before deciding either is…
Measurement error in a self-reported exposure Replied, post #70 · Evidence › Study critique · 25 Feb 2026 · 16 likes Where I part company with post #68, and it is a narrow parting. One more thing on measurement error that took me far too long to see: the two figures people quote are…
Choosing which test to pay for, given a fixed budget Replied, post #5 · Sourcing › Independent verification · 24 Feb 2026 · 0 likes A record with four results over sixteen months is a thin record rather than a bad one, and the honest description says which. The literature is thinner on this than the…
Nausea profile of amylin analogues compared with GLP-1 agonists Replied, post #16 · Compounds › Cagrilintide & amylin analogues · 20 Feb 2026 · 0 likes I read post #12 twice before replying, because I had assumed the opposite. What is genuinely unknown about long-term amylin agonism: real-world response rates, whether…
Follow-up: Evidence quality in the secretagogue literature: an honest assessment Replied, post #14 · Compounds › Secretagogues & GH axis · 16 Feb 2026 · 27 likes Evidence quality is one of those subjects where the general answer and the answer for a specific case diverge, and the thread will go in circles until someone says…
Coming back to: Pen dose counters: what a click does and does not guarantee Replied, post #5 · Devices › Pens & autoinjectors · 11 Feb 2026 · 0 likes A pen that will not dial to the intended dose is usually telling you the cartridge does not contain enough for it. That is a designed behaviour rather than a fault.
The most common factual error about semaglutide on the internet — what changed since Replied, post #22 · Compounds › Semaglutide · 7 Feb 2026 · 16 likes Worth separating two things this subcategory keeps merging: what the molecule does, which is reasonably well characterised, and what a particular vial contains, which…
Guidelines revision: what changed and why — one year on Replied, post #67 · Meta › Announcements · 6 Feb 2026 · 11 likes Careful with the language on Guidelines revision. "Not detected" and "not present" are different findings and the first is a statement about the method.
Gastro-oesophageal reflux: improving or worsening? Replied, post #16 · Clinical › Comorbidities · 3 Feb 2026 · 0 likes The honest answer on gastro-oesophageal reflux is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much they…
Trifluoroacetate content and its consequences Replied, post #41 · Analytics › Impurities & related substances · 29 Jan 2026 · 17 likes That last point is the ceiling on what any purity figure can claim. A method that cannot see a species cannot exclude it, and no certificate says which species its…
Revisiting: Absolute versus relative contraindications Replied, post #15 · Safety › Contraindications · 28 Jan 2026 · 17 likes Adding the measurement that post #12 says would settle it. Concurrent insulin or sulfonylureas: not an absolute contraindication but requires dose adjustment and close…
What a stability-indicating method is and how you demonstrate one Replied, post #3 · Analytics › Method validation · 13 Jan 2026 · 5 likes Range: the concentration range over which the method has been validated. Going outside the validated range is going outside the method's demonstrated performance.
Follow-up: Search filters: what is missing Replied, post #12 · Meta › Site feedback · 10 Jan 2026 · 0 likes Feature requests: if the site would work better with a feature it does not have (better search, different filtering, new section) suggest it here with the reasoning.…
Ultrasound and skinfolds: operator dependence in practice — what changed since Replied, post #6 · Outcomes › Body composition · 8 Jan 2026 · 0 likes Answering the question post #2 raises rather than the one it answers. Bioimpedance is considerably less precise and is strongly affected by hydration state, which is…
AOD-9604 and the fragment hypothesis, revisited Replied, post #39 · Compounds › Other compounds · 31 Dec 2025 · 31 likes When "no data" is the complete and final answer: if there is no published human data on a compound, that is the state of knowledge. Hope is not a substitute and…
Early satiety becoming a problem rather than a benefit Replied, post #19 · Practice › Side effects · 25 Dec 2025 · 0 likes Post #16 is the version of this I will quote in future. One addition. I would rather this thread reach "we do not know" about early satiety than reach a confident…
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #26 · Research Methods › N-of-1 designs · 10 Dec 2025 · 29 likes Confirming post #23 from a second method, which matters more than confirming it from a second person. A rolling mean over several days is far more informative than any…
Pen dose counters: what a click does and does not guarantee Replied, post #96 · Devices › Pens & autoinjectors · 19 Nov 2025 · 0 likes A pen delivers a fixed or dialled dose from a cartridge and is a metering device rather than simply a covered syringe. That is why dose changes are constrained to…
Pen mechanics when the cartridge is nearly empty — does this still hold? Replied, post #15 · Devices › Pens & autoinjectors · 10 Nov 2025 · 0 likes Off-label dosing with a pen: if you want to deliver a dose different from the pen's pre-set steps (e.g., halfway between two step doses), that is off-label use. Some…
Titles that describe the question, not the situation Replied, post #142 · Start Here › How to Ask · 6 Nov 2025 · 5 likes Post #140 put the caveat in the right place and I want to underline it. Titles is a good example of a question where the honest answer is boring and the interesting…
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #41 · Compounds › Tirzepatide · 20 Oct 2025 · 2 likes Where I have landed on SURMOUNT-4, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise magnitude has borrowed…
Sleep tracking data and its considerable limitations Replied, post #36 · Wellbeing › Sleep · 19 Oct 2025 · 1 like For anyone finding this later: the short answer on sleep is that it depends on one thing, and the rest of the thread is people identifying which thing.
Coming back to: Why most self-reports here are not experiments, and that is fine Replied, post #9 · Research Methods › N-of-1 designs · 2 Oct 2025 · 24 likes I had written a reply contradicting post #7 and deleted it. Here is what survived. Generalisability: a robust n-of-1 result applies to you. It does not tell you much…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #105 · Compounds › Oral incretins · 20 Sep 2025 · 13 likes I had written a reply contradicting post #103 and deleted it. Here is what survived. Anyone comparing published oral and injectable efficacy should check whether the…
Temperature loggers worth the money Replied, post #30 · Devices › Cold chain · 15 Sep 2025 · 21 likes Two things can be true about temperature loggers worth the money at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the…
Payment method and the leverage it gives you, ranked Replied, post #5 · marked as the solution · Sourcing › Payments · 13 Sep 2025 · 7 likes Fraud and scams: if a supplier demands payment upfront with no recourse if delivery fails, you are taking a risk. Reputation and history of other buyers matter.
Aggregated purity results across four services, with caveats — a second dataset Replied, post #95 · Data & Tools › Datasets · 10 Sep 2025 · 4 likes Aggregated purity results across four looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in…
Aggregated purity results across four services, with caveats — a second dataset Replied, post #74 · Data & Tools › Datasets · 9 Sep 2025 · 24 likes Post #72 and I disagree about the size of the effect, not about the direction. Where I have landed on Aggregated purity results across four, having got it wrong once in…
How to research a compound with no human data without deceiving yourself Replied, post #95 · Compounds › Other compounds · 4 Aug 2025 · 0 likes Two sentences on research a compound and then I will stop, because the rest is speculation and the thread is better without mine. What is documented is narrow. What is…
Second pass at: Reading a combination trial: attributing effect to components Replied, post #42 · Compounds › Cagrilintide & amylin analogues · 17 Jul 2025 · 0 likes Since Reading a combination trial keeps coming up, it should probably be a maintained page rather than a recurring thread. I am happy to draft it if someone with more…
EU-wide position versus national implementation Replied, post #18 · Regional › European Union · 16 Jul 2025 · 8 likes Post #16 put the caveat in the right place and I want to underline it. The public assessment report published at authorisation is one of the best free technical…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #87 · Wellbeing › Mental health · 11 Jul 2025 · 22 likes Taking post #86 at face value and following it one step further. Mood and anxiety: mood changes and anxiety are reported by some people. Baseline mental health status…
Distinguishing a deletion sequence by mass alone — the long version Replied, post #32 · Analytics › Mass spectrometry · 8 Jul 2025 · 25 likes Seconded. It reads as careful rather than confident, which is the right register.
Follow-up: The decimal-point error, and the habit that catches it Replied, post #22 · Practice › Reconstitution · 8 Jul 2025 · 2 likes Adding what did not work for me on decimal-point error, since the failures never get written up and they are half the useful information.
A report I filed that turned out to be wrong, and the correction Replied, post #131 · Sourcing › Vendor reports · 1 Jul 2025 · 17 likes Report the certificate figure alongside the independent one. The comparison is the point and it is the part most often omitted. I would treat that as a working…
Obstructive sleep apnoea and a hard endpoint in this class Replied, post #124 · Clinical › Comorbidities · 25 Jun 2025 · 0 likes PCOS and metabolic overlap: polycystic ovary syndrome has metabolic overlap with obesity and insulin resistance. Data on compounds in this class in PCOS specifically is…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #144 · Practice › Reconstitution · 24 Jun 2025 · 33 likes Arithmetic step by step: a 5 mg vial with 2 mL of diluent gives (5 mg) / (2 mL) = 2.5 mg/mL. On a U-100 syringe at that concentration, 100 units = 1 mL = 2.5 mg, so…
Second pass at: Pharmacy supply in the UK and the questions you will be asked Replied, post #47 · Regional › UK & Ireland · 21 Jun 2025 · 14 likes Source for the Pharmacy supply figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version circulating is stronger than…
Coming back to: When "no data" is the complete and final answer Replied, post #6 · Compounds › Other compounds · 5 Jun 2025 · 1 like For any compound without a widely available reference standard, retention-time comparisons across laboratories are close to meaningless. Only a mass result travels.
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #38 · Compounds › Oral incretins · 27 May 2025 · 0 likes The arithmetic in post #37 is right; the assumption feeding it is the part to check. Research-use-only oral material is not a licensed tablet and there is no reason to…
Half-life, steady state, and accumulation worked through Replied, post #16 · Pharmacology › Pharmacokinetics · 23 May 2025 · 11 likes Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5 half-lives (about 4 to 5 weeks). Before that,…
Reading a trial's population section before its results — does this still hold? Replied, post #133 · Evidence › Trials · 22 May 2025 · 1 like Trial duration determines what can be observed. A weight-change trajectory at 40 weeks and at 72 weeks are different observations and both get quoted as the result.…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #109 · Compounds › Semaglutide · 8 May 2025 · 14 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Antibiotics and a course of something with delayed emptying Replied, post #33 · Practice › Interactions · 3 May 2025 · 0 likes Two questions I would want answered before drawing anything from the antibiotics data above: how were the cases selected, and what happened to the ones that dropped out.
Adjudicated events and why the definition matters — the long version Replied, post #120 · Evidence › Trials · 26 Apr 2025 · 32 likes Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
Reading an MS report that only gives you a single number Replied, post #55 · Analytics › Mass spectrometry · 17 Apr 2025 · 17 likes Electrospray ionisation produces multiply charged ions. For a 4 kDa peptide you expect mostly 2+, 3+, and 4+ charge states. Reading an electrospray spectrum means…
Requesting a page: what makes a good request Replied, post #51 · Documentation › Wiki requests · 9 Apr 2025 · 16 likes Requests for a page summarising a supplier are declined, because that is what the vendor documentation set is for and it has its own standards.
UK access routes, dated and sourced — a second dataset Replied, post #57 · Regional › UK & Ireland · 30 Mar 2025 · 0 likes Where guidance distinguishes between indications, quoting the indication is essential. The same compound has different positions under different indications. This is…
Second pass at: Cross-border purchase within the EU: the actual rules Replied, post #129 · Access › International · 28 Mar 2025 · 16 likes On post #127 — agreed on the reasoning, with one qualification. My understanding of Cross-border purchase within is a few years old and may have been superseded. If it…
Documenting a supplier's response to a discrepancy — does this still hold? Replied, post #13 · Sourcing › Vendor reports · 22 Mar 2025 · 5 likes Do not adjust a reported figure. Post what the laboratory said and put your interpretation in a separate sentence.
Adducts: sodium, potassium, and the peak you did not expect Replied, post #41 · Analytics › Mass spectrometry · 21 Mar 2025 · 14 likes Where I part company with post #39, and it is a narrow parting. Distinguishing three things in the adducts discussion that keep getting used interchangeably: the…
Maintainer handover: how it works Replied, post #54 · Meta › Wiki maintenance · 17 Mar 2025 · 17 likes Careful with that. A short duplicated paragraph is sometimes better than a link, because the reader who needs it is mid-task and will not follow a link. The test is…
Journal club: SURMOUNT-1, read without the press release Replied, post #72 · Evidence › Journal club · 6 Mar 2025 · 0 likes Taking SURMOUNT-1 seriously for a moment rather than deflecting: the honest position is that the community has observations and no controlled comparison, and those two…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #131 · Sourcing › Regulatory · 5 Mar 2025 · 1 like Pharmaceutical compounding rules is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
A promotion I argued against, and why I lost Replied, post #110 · Documentation › Doc review · 24 Feb 2025 · 32 likes This follows post #109 rather than contradicting it. Worth stating the null on promotion before we explain it: the observation may be nothing. That possibility deserves…
A certificate whose chromatogram axes do not match its stated method Replied, post #5 · Sourcing › Red flags · 22 Feb 2025 · 3 likes Patterns that reliably precede a problem: underdosing (less active material than stated, documented by independent testing), mislabelling (wrong compound, wrong…
Anaesthesia and elective surgery: the aspiration question — does this still hold? Replied, post #24 · Practice › Interactions · 18 Feb 2025 · 2 likes The practical version of Anaesthesia and elective surgery is three sentences long. The rigorous version is three pages and reaches the same conclusion with the…
What we do not know about retatrutide, listed explicitly Replied, post #85 · Compounds › Retatrutide · 6 Feb 2025 · 2 likes Post #81 and I disagree about the size of the effect, not about the direction. A theoretical mass for retatrutide is not published in the peer-reviewed literature in a…
Protein density versus volume when you cannot eat much Replied, post #41 · Nutrition & Training › Protein & intake · 30 Jan 2025 · 0 likes Adequate protein during a substantial deficit is the part of this conversation that gets least attention and probably deserves most. Where I would look next, rather…
Canadian access and provincial variation Replied, post #14 · Regional › North America · 23 Jan 2025 · 0 likes That is clearer than the version I had in my head. Thank you.
Identical chromatograms across two different lots Replied, post #80 · Sourcing › Red flags · 22 Jan 2025 · 6 likes Since identical chromatograms keeps coming up, it should probably be a maintained page rather than a recurring thread. I am happy to draft it if someone with more…
HbA1c lag and what it can and cannot tell you at eight weeks Replied, post #3 · Clinical › Bloodwork · 19 Jan 2025 · 7 likes The claim about hba1c lag upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says "causes".
Recovery when intake is low: what to cut first Replied, post #67 · Nutrition & Training › Resistance training · 13 Jan 2025 · 25 likes Saving this. It is the version I will quote when the question comes round again.
Molecular mass of semaglutide and why the figure differs between sources — does this… Replied, post #79 · Compounds › Semaglutide · 23 Dec 2024 · 0 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #159 · Analytics › COA interpretation · 21 Dec 2024 · 2 likes A certificate is a statement by its issuer that a defined test was performed on a defined lot and produced a defined result. That is all it is, and it is not nothing. I…
Coming back to: When to suspect the method rather than the sample Replied, post #103 · Analytics › Method validation · 20 Dec 2024 · 6 likes Narrowing post #100, because the general version has more than one answer. Forced degradation studies: deliberately stress the material with acid, base, oxidant, heat,…
Injection-site reactions: describing them precisely enough to be useful Replied, post #33 · Practice › Side effects · 29 Nov 2024 · 0 likes The arithmetic in post #32 is right; the assumption feeding it is the part to check. Reporting rather than recommending, on injection-site reactions. What happened is…
SURPASS-2 and the comparator dose question that will not go away Replied, post #65 · Compounds › Tirzepatide · 26 Nov 2024 · 0 likes I have no financial interest in anything named in this thread and I want to say so before I comment on SURPASS-2, because it is the sort of subject where it matters.
Fixed versus detachable needles: the trade-offs Replied, post #17 · Devices › Syringes & needles · 24 Nov 2024 · 0 likes Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach…
Type 1 diabetes: off-label use and the evidence gap — what changed since Replied, post #11 · Clinical › Special populations · 19 Nov 2024 · 7 likes Post #8 is right about the mechanism and I think understates the practical bit. The claim about Type 1 diabetes upthread is stronger than its source supports. I have…
Time to steady state after a dose increase Replied, post #136 · Pharmacology › Pharmacokinetics · 6 Nov 2024 · 33 likes I had written a reply contradicting post #134 and deleted it. Here is what survived. The time to maximum concentration after a subcutaneous dose in this class is…
Revisiting: Holding a dose indefinitely: is there a documented downside? Replied, post #4 · Practice › Dosing & titration · 29 Oct 2024 · 0 likes Post #2 is right about the mechanism and I think understates the practical bit. The most useful reply I ever got about Holding a dose was a request to state my units.…
Coming back to: Research-use-only labelling: what it means and what it does not Replied, post #12 · Sourcing › Regulatory · 23 Oct 2024 · 0 likes Nothing in this subcategory is legal advice, and the members who work in regulated environments are the most careful to say so. Posted with less confidence than the…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #69 · Clinical › Comorbidities · 20 Oct 2024 · 0 likes Taking post #66 at face value and following it one step further. Small correction to my own earlier position on Hypertension improvement. I had the units the wrong way…
Food noise reducing and the disorientation that can follow Replied, post #14 · Wellbeing › Mental health · 29 Sep 2024 · 6 likes Food noise: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.
Reading a supplementary appendix and finding the interesting part Started this topic · Evidence › Trials · 29 Sep 2024 · 52 likes Reading a supplementary appendix and finding the interesting part — setting out what I have, and where I think it stops being reliable. Collecting what is known about…
Gallbladder disease risk with rapid weight loss Replied, post #12 · Clinical › Comorbidities · 23 Sep 2024 · 1 like Asking about a population rather than about yourself is a legitimate framing and generally gets a better answer, because the general case is answerable. The…
Reporting a discrepancy without making an allegation Replied, post #43 · Sourcing › Vendor reports · 26 Aug 2024 · 29 likes Photograph the vial and the label before opening. It costs ten seconds and it is what turns a report into something checkable. None of the above is medical advice and I…
Coming back to: What consumer-accessible tests can and cannot determine Started this topic · Analytics › Home & field testing · 18 Aug 2024 · 28 likes Asking directly, because I could not find a straight answer: What consumer-accessible tests can and cannot determine Something about consumer-accessible tests does not…
How this community labels and discusses unrefereed work Replied, post #98 · Evidence › Preprints · 20 Jul 2024 · 0 likes How to cite a preprint: author last name, first initial, et al. Title. Server name [preprint]. Posted date. Doi. Include the server name and note that it is a preprint.…
Second pass at: Journal club: LEADER as the historical anchor Replied, post #10 · Evidence › Journal club · 8 Jul 2024 · 4 likes On post #6 — agreed on the reasoning, with one qualification. Since LEADER keeps coming up, it should probably be a maintained page rather than a recurring thread. I am…