k.radich

TL2 · Graz

Contributes reviews on supplier material. Based in Graz.

Joined 14 November 2024 · last posted 3d

89 posts, newest first. Showing up to 150.

Common supplements people ask about, assessed one at a time Replied, post #95 · Practice › Interactions · 25 Jul 2026 · 1 like Useful. I had the fact and not the reason, which turns out to be the important half.
Seven-day rolling means and why weekly readings mislead Replied, post #77 · Outcomes › Progress reports · 21 Jul 2026 · 23 likes Thank you for taking the time. That was more work than a reply usually is.
Reading order for a first week here, and what to skip until later — what changed since Replied, post #63 · Start Here › Welcome · 20 Jul 2026 · 0 likes Reading counts toward trust level, so lurking is not wasted. That is unusual and it is the reason the levels here track familiarity rather than volume. I looked this up…
Submitting a sample: the process end to end Replied, post #61 · Sourcing › Independent verification · 6 Jul 2026 · 19 likes Narrowing post #60, because the general version has more than one answer. Filing a mild objection to the consensus on submitting a sample. Mild because I might be…
[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #5 · Analytics › HPLC & UHPLC · 1 Jul 2026 · 13 likes Where I part company with post #4, and it is a narrow parting. Where the Detection wavelength discussion usually stalls is that nobody wants to say "I do not know" and…
What consumer-accessible tests can and cannot determine — a second dataset Replied, post #30 · Analytics › Home & field testing · 26 Jun 2026 · 1 like Picking up post #29: that is the part I would want checked first. Two people in this thread mean different things by consumer-accessible tests and are disagreeing about…
Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #13 · Compounds › Retatrutide · 23 Jun 2026 · 0 likes The version of retatrutide discussion that I was taught turned out to be a teaching simplification. Useful, and not true in the way I had assumed it was.
Micronutrient adequacy at low total intake Replied, post #30 · Nutrition & Training › Protein & intake · 8 Jun 2026 · 0 likes Adding the measurement that post #28 says would settle it. What I would check first on micronutrient adequacy is whether the thing being measured moved or whether the…
A checklist for reading a certificate in under two minutes Replied, post #36 · Analytics › COA interpretation · 8 Jun 2026 · 12 likes When method identifiers are missing: "reversed-phase HPLC" is less specific than "reversed-phase HPLC at 214 nm on a C18 column with a 10 to 40% acetonitrile gradient…
Lean mass preservation: what the evidence supports — does this still hold? Replied, post #91 · Outcomes › Body composition · 8 Jun 2026 · 2 likes Comparison to published data: the trials reported mean fat and lean mass changes. Individual results vary around that mean. Being above or below average is not a sign…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #84 · Sourcing › Red flags · 6 Jun 2026 · 0 likes Keep the two claims separate. "The result on this lot did not match the certificate" is a report that can be checked. "This supplier is dishonest" is an allegation…
Injecting into an area that has become firm: why not to Replied, post #19 · Practice › Administration · 5 Jun 2026 · 23 likes If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.
Bariatric surgery history: altered anatomy, altered expectations Replied, post #26 · Clinical › Special populations · 27 May 2026 · 1 like Bariatric surgery history would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
CJC-1295 with and without DAC: what the modification does Replied, post #66 · Compounds › Secretagogues & GH axis · 25 May 2026 · 0 likes Reading back through the CJC-1295 threads from last year, the same three questions come up every time and only one of them has ever been answered properly. That seems…
[2026 update] A vial that will not fully dissolve: what to check and in what order Replied, post #59 · Practice › Reconstitution · 18 May 2026 · 27 likes Concentration is total mass divided by total volume, and everything else follows from that. Ten milligrams into two millilitres is five milligrams per millilitre, and…
Tracking a shortage from primary sources rather than rumour Replied, post #7 · Access › Shortages · 12 May 2026 · 28 likes Helpful, and short, which on this subject is harder than long.
Splitting an overlong document into two Replied, post #16 · Documentation › Wiki requests · 30 Apr 2026 · 23 likes A note on scope: what I am saying about splitting an overlong document applies to the case in the first post and I would not extend it further without checking.
Prescription portability between countries Replied, post #17 · Access › International · 26 Apr 2026 · 9 likes Customs practice varies between entry points within the same country, which is why two people in the same jurisdiction report different experiences honestly.
Pregnancy and pregnancy planning: contraindication and washout Replied, post #117 · Clinical › Special populations · 20 Apr 2026 · 20 likes Adding a data point of agreement rather than a data point.
[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #45 · Devices › Syringes & needles · 20 Apr 2026 · 7 likes Thank you for taking the time. That was more work than a reply usually is.
Five questions in one post gets you one answer — how to split them Replied, post #59 · Start Here › How to Ask · 19 Apr 2026 · 21 likes Disagreement-style questions: "I read this and it contradicts what I heard here, which is right?" is answerable. "Is this a bad idea?" without giving the context is…
Foaming during reconstitution and whether it matters — the long version Replied, post #104 · Practice › Reconstitution · 19 Apr 2026 · 0 likes Clear enough that I do not think I have a follow-up, which is unusual.
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #87 · Compounds › Tirzepatide · 18 Apr 2026 · 28 likes Where I part company with post #83, and it is a narrow parting. The 2.5 mg starting dose is not a therapeutic dose in the sense that weight loss is minimal at that…
Blinding yourself: practical methods and their limits Replied, post #18 · Research Methods › N-of-1 designs · 15 Apr 2026 · 15 likes I have been on both sides of the blinding yourself argument in this category within eighteen months, which should tell you how strong the evidence for either side is.
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #2 · Evidence › Journal club · 11 Apr 2026 · 7 likes The failure mode on STEP 1 is boring rather than dramatic. It is almost always the step everyone assumes was done correctly because it is too simple to get wrong.
Second pass at: Sleep apnoea improving and the equipment implications Replied, post #9 · Wellbeing › Sleep · 5 Apr 2026 · 5 likes The published data on sleep outcomes in this class is thinner than the volume of discussion, which is worth saying plainly. That is all I can say without guessing.
Why the timeline is on the right and not the left — what changed since Replied, post #13 · Meta › Site feedback · 30 Mar 2026 · 9 likes Post #10 is right about the mechanism and I think understates the practical bit. Navigation problems: if you cannot find something you expected to exist, or the path to…
The "under review" status pill and when a moderator applies it Replied, post #37 · Evidence › Preprints · 25 Mar 2026 · 5 likes On post #34 — agreed on the reasoning, with one qualification. Reading a preprint properly means doing some of the reviewer's job: methods first, then whether the…
Sample handling between despatch and injection Started this topic · Analytics › Method validation · 25 Mar 2026 · 19 likes Sample handling between despatch and injection Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #69 · Practice › Storage & stability · 21 Mar 2026 · 16 likes The number people quote for Adsorptive losses is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly…
Splitting a weekly dose in two: the pharmacokinetic argument against Replied, post #15 · Practice › Dosing & titration · 8 Mar 2026 · 0 likes Reading rather than answering, but this is the post I would point somebody at.
Adducts: sodium, potassium, and the peak you did not expect — does this still hold? Replied, post #50 · Analytics › Mass spectrometry · 26 Feb 2026 · 0 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass. Flagging that the…
Anaesthesia and elective surgery: the aspiration question Replied, post #31 · Practice › Interactions · 24 Feb 2026 · 0 likes Adding what did not work for me on anaesthesia and elective surgery, since the failures never get written up and they are half the useful information.
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #132 · Practice › Dosing & titration · 22 Feb 2026 · 7 likes Split dosing within a week is sometimes proposed to smooth tolerability. With a week-long half-life the concentration is already smooth, so what it would change is the…
Managing an unplanned gap in supply Replied, post #17 · Access › Shortages · 29 Jan 2026 · 22 likes Dose hold versus tapering: if a temporary shortage forces a gap, holding your dose and resuming when supply returns is different from gradually tapering. The two are…
Personal import allowances, compared — a second dataset Replied, post #58 · Access › International · 26 Jan 2026 · 0 likes Grateful for the specificity. Vague answers to this question are what sent me looking.
Reading an interaction checker output critically Replied, post #76 · Practice › Interactions · 26 Dec 2025 · 3 likes On reading an interaction checker output, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of…
Which panel is worth repeating and which is worth ignoring — a second dataset Replied, post #27 · Clinical › Bloodwork · 12 Dec 2025 · 9 likes Taking post #24 at face value and following it one step further. Counterpoint on panel, offered without confidence: the same observation is consistent with a much…
[2026 update] Storing lyophilised material long term: what governs the shelf life Replied, post #28 · Practice › Storage & stability · 27 Nov 2025 · 0 likes I would rather this thread reach "we do not know" about Storing lyophilised material long term than reach a confident answer that nobody can support when asked.
Severe gastroparesis and why this class is a poor fit — one year on Replied, post #9 · Safety › Contraindications · 21 Nov 2025 · 7 likes Worth separating two things that post #7 runs together. Asking a pharmacist to check a contraindication takes minutes and is more reliable than any thread, including…
[2026 update] Reporting a disappointing outcome, and why it belongs here Started this topic · Outcomes › Progress reports · 18 Nov 2025 · 17 likes On the subject in the title: Reporting a disappointing outcome, and why it belongs here Working notes rather than a conclusion. Proposing that Reporting a disappointing…
A comparison of home results against a laboratory result on the same vial Replied, post #60 · Analytics › Home & field testing · 8 Nov 2025 · 26 likes Reading a colorimetric result at the wrong time is the commonest procedural error. Development is time-dependent and the window is usually narrow. I would be interested…
Pharmaceutical compounding rules, summarised from primary sources — a second dataset Replied, post #17 · Sourcing › Regulatory · 5 Nov 2025 · 0 likes On post #14 — agreed on the reasoning, with one qualification. The reason Pharmaceutical compounding rules is hard to answer is that the obvious measurement and the…
Tirzepatide molecular mass and the charge states you would expect on ESI — does this… Replied, post #4 · Compounds › Tirzepatide · 16 Oct 2025 · 23 likes Answering the question the opening post raises rather than the one it answers. The five maintenance doses in the tirzepatide programme give a genuine dose-response…
Second pass at: How to ask a question when you cannot say why you are asking it Replied, post #21 · Start Here › How to Ask · 8 Oct 2025 · 0 likes When you quote a figure from somewhere else, say where from. Not as a formality — the answer frequently depends on whether the number came from a certificate, an…
Meeting a protein target on a suppressed appetite Replied, post #24 · Nutrition & Training › Protein & intake · 26 Sep 2025 · 0 likes Protein supplements: whey, casein, and plant-based protein powders can help hit targets when whole-food intake is limited by appetite. Protein quality (all essential…
Payment method and the leverage it gives you, ranked Replied, post #65 · Sourcing › Payments · 24 Sep 2025 · 0 likes A definition problem is doing most of the work in this payment method discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is…
Hypertension improvement and when medication needs revisiting Replied, post #58 · Clinical › Comorbidities · 13 Sep 2025 · 21 likes A methods point on hypertension improvement rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in…
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Replied, post #54 · Compounds › Semaglutide · 7 Sep 2025 · 10 likes The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule works. Below 4 half-lives you are not approaching steady state yet, which is…
Tirzepatide molecular mass and the charge states you would expect on ESI Replied, post #33 · Compounds › Tirzepatide · 29 Aug 2025 · 0 likes Post #31 is right about the mechanism and I think understates the practical bit. Dual agonism versus dose: how much of tirzepatide's effect is the GIP component and how…
The nausea timeline across the first four weeks, with a tabulated log Replied, post #9 · Practice › Side effects · 22 Aug 2025 · 0 likes On nausea timeline, I would rather understate and be corrected upward than overstate and be quoted. That is a house style here and it is a good one.
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #22 · Analytics › Mass spectrometry · 20 Jul 2025 · 9 likes An acylated peptide has a mass that reflects the modification, so comparing against the mass of the unmodified backbone gives a mismatch that is not an error. A single…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #141 · Devices › Cold chain · 12 Jul 2025 · 19 likes Insulation performance depends on the mass of the coolant more than on the thickness of the box. A large pack in a modest box outperforms a small pack in a good one.
Gauge and length selection for subcutaneous injection Replied, post #8 · Devices › Syringes & needles · 29 Jun 2025 · 0 likes Confirming post #6 from a second method, which matters more than confirming it from a second person. Adding a small correction to the gauge and length selection summary…
A claim built entirely on a subgroup analysis Replied, post #71 · Evidence › Study critique · 2 Jun 2025 · 13 likes Generalisability and validity are separate axes. A trial can be internally impeccable and still tell you nothing about the person asking.
Second pass at: Pen dose counters: what a click does and does not guarantee Replied, post #47 · Devices › Pens & autoinjectors · 23 May 2025 · 3 likes Needle changes between doses are specified for a reason and the reasons are dose accuracy and sterility rather than comfort alone.
A report I filed that turned out to be wrong, and the correction Replied, post #61 · Sourcing › Vendor reports · 19 May 2025 · 17 likes Do not adjust a reported figure. Post what the laboratory said and put your interpretation in a separate sentence.
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Replied, post #35 · Evidence › Journal club · 19 May 2025 · 0 likes I think the SURMOUNT-4 and continuation versus withdrawal question is answerable and has not been answered, which is a more optimistic position than most of this thread.
Pregnancy as an absolute contraindication Replied, post #74 · Safety › Contraindications · 19 May 2025 · 3 likes Answering the question post #72 raises rather than the one it answers. Personal or family history of medullary thyroid carcinoma, or multiple endocrine neoplasia type…
A claim built entirely on a subgroup analysis Replied, post #39 · Evidence › Study critique · 17 May 2025 · 13 likes A note on how claim built gets discussed rather than on claim built itself: the confident posts get the replies and the careful ones get ignored, and the careful ones…
Criticising the method without criticising the authors Replied, post #62 · Evidence › Study critique · 6 May 2025 · 0 likes Adding the measurement that post #61 says would settle it. Worth stating the null on criticising the method without criticising before we explain it: the observation…
Asking about a compound your prescriber has not heard of Replied, post #29 · Clinical › Prescriber conversations · 1 May 2025 · 21 likes Answering the question post #25 raises rather than the one it answers. If time runs out, asking what to do next — book again, phone, message — is better than leaving…
Reading a trial's population section before its results — does this still hold? Replied, post #19 · Evidence › Trials · 18 Apr 2025 · 22 likes Trial duration determines what can be observed. A weight-change trajectory at 40 weeks and at 72 weeks are different observations and both get quoted as the result.…
Carryover and the ghost peak from last week's standard Replied, post #86 · Analytics › HPLC & UHPLC · 11 Apr 2025 · 26 likes The arithmetic on carryover is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.
Reading order for a first week here, and what to skip until later Replied, post #65 · Start Here › Welcome · 3 Apr 2025 · 19 likes Marked solutions are the site's way of saying that someone asked a good question and someone else gave an answer that actually worked. It is not a competition and it…
Requesting a translation of an existing page Replied, post #4 · Documentation › Wiki requests · 24 Mar 2025 · 30 likes The arithmetic in post #3 is right; the assumption feeding it is the part to check. Requests for a page summarising a supplier are declined, because that is what the…
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Replied, post #30 · Compounds › Secretagogues & GH axis · 24 Mar 2025 · 9 likes On Tesamorelin: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply here…
Maintainer handover: how it works Replied, post #76 · Meta › Wiki maintenance · 19 Mar 2025 · 19 likes The question underneath maintainer handover is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it. Write down what you…
What SELECT changed about how semaglutide is discussed, and what it did not Replied, post #44 · Compounds › Semaglutide · 18 Mar 2025 · 8 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
Amylin analogue mechanism: satiety signalling separate from GLP-1 Replied, post #79 · Compounds › Cagrilintide & amylin analogues · 11 Mar 2025 · 31 likes Thank you for taking the time. That was more work than a reply usually is.
Second pass at: Regression to the mean in progress reports Replied, post #68 · Research Methods › Statistics · 26 Feb 2025 · 33 likes This follows post #65 rather than contradicting it. Bayesian and frequentist analyses answer different questions and both are legitimate. What matters is that the…
A page that has drifted out of date and needs a maintainer Replied, post #68 · Documentation › Wiki requests · 24 Feb 2025 · 0 likes Post #67 describes the usual case. This is about the unusual one. Request a new maintained page: if a question recurs, has a good marked solution, and contains a worked…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #31 · Practice › Reconstitution · 11 Feb 2025 · 0 likes Agreed, and I will stop repeating the version of this I had been repeating.
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #82 · Evidence › Meta-analyses · 9 Feb 2025 · 0 likes Coming back to post #81, because the follow-up matters more than the original answer. High heterogeneity is the finding rather than a nuisance to be minimised. If the…
Random versus fixed effects: choosing rather than defaulting — a second dataset Replied, post #61 · Evidence › Meta-analyses · 6 Feb 2025 · 1 like Clear enough that I do not think I have a follow-up, which is unusual.
What changed in 2026, by region Replied, post #105 · Access › International · 28 Jan 2025 · 10 likes I read post #102 twice before replying, because I had assumed the opposite. Regulatory position dates: a regulatory position is only current as of when it was written.…
Follow-up: Individual participant data versus aggregate data Replied, post #100 · Evidence › Meta-analyses · 11 Jan 2025 · 10 likes Worth separating two things that post #98 runs together. Something worth flagging about Individual participant data versus aggregate: the strongest-sounding claims in…
Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide Replied, post #59 · Compounds › Semaglutide · 30 Dec 2024 · 0 likes Thank you — that answers what I came here to find out.
Gallbladder disease risk with rapid weight loss Replied, post #49 · Clinical › Comorbidities · 27 Dec 2024 · 2 likes Obstructive sleep apnoea: SURMOUNT-OSA used an objective endpoint, the apnoea-hypopnoea index. Reduction was substantial. Whether the benefit is weight loss or a direct…
Oral semaglutide bioavailability and its variability between people — a second dataset Replied, post #3 · Compounds › Oral incretins · 24 Dec 2024 · 0 likes Trying to state the Oral semaglutide bioavailability position in a way that someone who disagrees would recognise as fair, because I do not think the version in this…
Body image changing more slowly than the body Replied, post #42 · Wellbeing › Mental health · 15 Dec 2024 · 0 likes This follows post #41 rather than contradicting it. Expectations set by other people's reported trajectories are a documented source of distress, and the trajectories…
Follow-up: Oral contraceptives and delayed emptying: what the data shows Replied, post #29 · Practice › Interactions · 7 Dec 2024 · 0 likes Where I part company with post #27, and it is a narrow parting. Oral medications versus time: if you take an oral medication 30 minutes before semaglutide (which slows…
EMA product information as a primary source — does this still hold? Replied, post #45 · Regional › European Union · 16 Nov 2024 · 0 likes Answering the question post #41 raises rather than the one it answers. France: ANSM implements EU framework. Reimbursement has been narrower for weight management.…
Promotion criteria, and the one that stops most nominations Replied, post #90 · Documentation › Doc review · 19 Oct 2024 · 0 likes Review of promoted topics: when a topic is nominated for promotion to a maintained documentation page, the draft is posted here. Community review happens before…
Transit times by route, from a logged dataset — the long version Replied, post #17 · Sourcing › Logistics · 3 Oct 2024 · 12 likes The practical version of Transit times is three sentences long. The rigorous version is three pages and reaches the same conclusion with the conditions attached.
Why we hide unevidenced fraud accusations and log the hiding Started this topic · Sourcing › Red flags · 21 Sep 2024 · 1 like Why we hide unevidenced fraud accusations and log the hiding — that is the question, and I have not found it answered plainly anywhere I have looked. Filing a…
Correlation in a self-tracked dataset: what it can support Replied, post #119 · Research Methods › Statistics · 24 Aug 2024 · 24 likes I read post #115 twice before replying, because I had assumed the opposite. Where the correlation reasoning breaks down for me is the step from the group result to the…
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #15 · Analytics › COA interpretation · 29 Jul 2024 · 22 likes Where the field-by-field walk through a certificate reasoning breaks down for me is the step from the group result to the individual case. That step is almost never…
Where the four-week escalation interval comes from, and what it is not Replied, post #11 · Practice › Dosing & titration · 1 Jun 2024 · 28 likes Where I have landed on four-week escalation interval, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise…