Latest topics page 51

Topics ordered by most recent activity across all 71 subcategories.

1,535 topics · page 51 of 52

Topic	Participants	Replies	Views	Activity
Cold packs, phase-change material, and what survives ten days — does this still hold? Sourcing › Logistics packaging temperature excursion customs shipping Asking directly, because I could not find a straight answer: Cold packs, phase-change material, and what survives ten days — does this still hold? I have spent a fortnight trying to pin Cold packs down and I…		2	22k	22mo
Hoarding and why it makes a shortage worse Access › Shortages formulary shortage compounding FDA Posting this under the heading it deserves: Hoarding and why it makes a shortage worse Everything below is what sits behind that. Documenting an access outcome, dated, because everything in this category…		2	12k	22mo
Revisiting: US compounding rules and how they changed Regional › North America insurance telehealth compounding On the subject in the title: Revisiting: US compounding rules and how they changed Working notes rather than a conclusion. Regional question, dated February 2026, because everything in this category expires.…	+5	9	26k	23mo
How to ask for a dose change without antagonising anyone Clinical › Prescriber conversations telehealth beginner friendly type 2 diabetes Solved The question in the title: How to ask for a dose change without antagonising anyone I will give what I have already checked below so nobody repeats it. A question about how to describe something to a…	+19	23	2.9k	23mo
[2026 update] People with a low starting BMI: where the evidence stops Clinical › Special populations chronic kidney disease adolescents pregnancy & planning bariatric surgery history People with a low starting BMI: where the evidence stops Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…	+19	23	62k	23mo
A rising related-substance total over six months: degradation or method drift? Analytics › Impurities & related substances data table endotoxin testing HPLC Closed Asking directly, because I could not find a straight answer: A rising related-substance total over six months: degradation or method drift? Rising related-substance — I have the observation and I do not trust…	+37	42	37k	23mo
Orforglipron as a non-peptide: what changes when the molecule is small Compounds › Oral incretins orforglipron SOUL trial PIONEER programme On the subject in the title: Orforglipron as a non-peptide: what changes when the molecule is small Working notes rather than a conclusion. What changes if the standard account of orforglipron is wrong? I ask…	+26	30	26k	23mo
Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Posting this under the heading it deserves: Reading a meta-analysis you disagree with, fairly Everything below is what sits behind that. I would like to disagree carefully with the settled view on reading a…	+7	13	2.5k	23mo
Circumference measurements as a poor man's composition estimate Outcomes › Body composition bioimpedance data table DXA lean mass loss Solved Posting this under the heading it deserves: Circumference measurements as a poor man's composition estimate Everything below is what sits behind that. Working notes on circumference measurements rather than a…	+96	112	14k	23mo
Correlation in a self-tracked dataset: what it can support Research Methods › Statistics effect size heterogeneity worked example number needed to treat Closed Correlation in a self-tracked dataset: what it can support — setting out what I have, and where I think it stops being reliable. Posting a small dataset on correlation. It is mine, it is uncontrolled, and the…	+152	166	48k	23mo
Follow-up: A partial dose because the pen emptied mid-injection Practice › Administration injection site reaction subcutaneous injection injection site rotation aseptic technique Posting this under the heading it deserves: A partial dose because the pen emptied mid-injection Everything below is what sits behind that. A follow-up question about partial dose because the pen that I did…	+10	14	10k	23mo
Chronic kidney disease and the FLOW result Clinical › Comorbidities PCOS blood pressure chronic kidney disease MASH / hepatic steatosis Solved Posting this under the heading it deserves: Chronic kidney disease and the FLOW result Everything below is what sits behind that. Chronic kidney disease: setting out the arithmetic in full, because I have had…	+34	38	33k	23mo
High-resolution MS on aggregates and what it can see — one year on Analytics › Mass spectrometry LC-MS counter-ion content MALDI-TOF charge states Solved High-resolution MS on aggregates and what it can see — one year on Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about High-resolution, deliberately…	+54	58	1.2k	23mo
Coming back to: Purity assay versus content assay: two different numbers Analytics › COA interpretation certificate of analysis reference standards batch & lot numbers Under review Purity assay versus content assay: two different numbers — setting out what I have, and where I think it stops being reliable. Asking about Purity assay versus content assay directly, because I have read four…	+71	77	31k	23mo
The most common factual error about semaglutide on the internet Compounds › Semaglutide STEP programme randomised trial type 2 diabetes effect size On the subject in the title: The most common factual error about semaglutide on the internet Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a compound…		2	49k	2y
Coming back to: Pricing far outside the range, in either direction Sourcing › Red flags documentation quality underdosing mislabelling Pricing far outside the range, in either direction Writing it up because I had to work it out twice and would rather nobody else did. Pricing far outside the range — I have the observation and I do not trust…	+22	26	325	2y
Naming conventions for research peptides and the confusion they cause — one year on Compounds › Other compounds research use only mislabelling needs a source Naming conventions for research peptides and the confusion they cause — one year on — setting out what I have, and where I think it stops being reliable. Asking about Naming conventions for research peptides…	+1	5	181	2y
[2026 update] Request: show the solution author in the topic list Meta › Feature requests site feedback wiki post translation Request: show the solution author in the topic list Writing it up because I had to work it out twice and would rather nobody else did. Bringing the figures rather than the impression, since a process question…		2	59	2y
Mean kinetic temperature explained without the mathematics Practice › Storage & stability temperature excursion freeze-thaw storage cloudy or discoloured solution Posting this under the heading it deserves: Mean kinetic temperature explained without the mathematics Everything below is what sits behind that. Two things I would like separated before anyone answers on…		2	1.5k	2y
The mass-error checker and its intended scope Data & Tools › Calculators worked example concentration maths syringe units site feedback The mass-error checker and its intended scope Writing it up because I had to work it out twice and would rather nobody else did. Proposing that mass-error checker deserves a maintained page rather than a…	+149	167	42k	2y
Second pass at: Journal club: LEADER as the historical anchor Evidence › Journal club randomised trial journal club effect size estimand Posting this under the heading it deserves: Second pass at: Journal club: LEADER as the historical anchor Everything below is what sits behind that. Two things I would like separated before anyone answers on…	+75	81	2k	2y
Guidelines revision: what changed and why Meta › Announcements guidelines moderation trust levels Guidelines revision: what changed and why Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about guidelines revision in a thread last spring and I would like to…	+125	142	1.7k	2y
How this community labels and discusses unrefereed work Evidence › Preprints risk of bias effect size preprint needs a source How this community labels and discusses unrefereed work — that is the question, and I have not found it answered plainly anywhere I have looked. Reading an unrefereed manuscript properly, and asking whether I…	+112	119	1.3k	2y
Follow-up: Conditions that change the calculus rather than forbidding it Safety › Contraindications pancreatitis disordered eating thyroid C-cell question pregnancy & planning Posting this under the heading it deserves: Conditions that change the calculus rather than forbidding it Everything below is what sits behind that. I was wrong about Conditions in a thread last spring and I…	+30	34	62k	2y
Where the four-week escalation interval comes from, and what it is not Practice › Dosing & titration missed dose semaglutide tirzepatide titration Solved On the subject in the title: Where the four-week escalation interval comes from, and what it is not Working notes rather than a conclusion. Working notes on four-week escalation interval rather than a…	+56	60	21k	2y
Refrigerated versus room temperature: the trade-off stated plainly Practice › Storage & stability cold chain cloudy or discoloured solution storage beyond-use date Refrigerated versus room temperature: the trade-off stated plainly Writing it up because I had to work it out twice and would rather nobody else did. The question about refrigerated versus room temperature…		2	66k	2y
Second pass at: Retatrutide dose escalation in the published trials Compounds › Retatrutide retatrutide randomised trial preprint Under review Second pass at: Retatrutide dose escalation in the published trials — setting out what I have, and where I think it stops being reliable. Two things I would like separated before anyone answers on Retatrutide…	+115	125	30k	2y
Cold packs, phase-change material, and what survives ten days Sourcing › Logistics shipping temperature excursion cold chain customs Cold packs, phase-change material, and what survives ten days — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin cold packs down and I want to set out…	+132	138	65k	2y
Oral contraceptives and delayed emptying: what the data shows Practice › Interactions metformin delayed gastric emptying insulin Solved Posting this under the heading it deserves: Oral contraceptives and delayed emptying: what the data shows Everything below is what sits behind that. The question about oral contraceptives and delayed emptying…	+63	71	5.9k	2y
Journal club: FLOW and the renal composite, component by component Evidence › Journal club randomised trial estimand risk of bias On the subject in the title: Journal club: FLOW and the renal composite, component by component Working notes rather than a conclusion. Reading FLOW ( N Engl J Med , 2024) for the population rather than the…	+84	91	18k	2y