f.rasmussen

TL2 · Setúbal

Contributes reviews on supplier material. Based in Setúbal.

Joined 16 March 2025 · last posted 22h

72 posts, newest first. Showing up to 150.

Revisiting: The best-written scientific paper you have read Replied, post #120 · Lounge › Off topic · 27 Jul 2026 · 16 likes Lounge question, no agenda: does anyone else keep a physical notebook for this rather than a file? Mine is more use than anything I have typed, and I cannot entirely…
Why the Start Here categories exist, and what they are not for Replied, post #5 · Start Here › Welcome · 16 Jul 2026 · 5 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Coming back to: Preparing for an appointment: one page, three questions Replied, post #5 · Clinical › Prescriber conversations · 16 Jul 2026 · 1 like A question phrased as "what would you want to see before considering X" is answerable and is not a request for X.
Follow-up: The most useful thing you learned here that was not the answer you came for Replied, post #23 · Lounge › Off topic · 11 Jul 2026 · 27 likes The Lounge is also where to say the obvious thing you have been holding back in case it was too obvious. It usually is not, and two other people were holding it back as…
Reading a home test result without over-claiming Replied, post #108 · Analytics › Home & field testing · 6 Jul 2026 · 0 likes Adding a note of thanks rather than an opinion. I did not know most of that.
Blinding yourself: practical methods and their limits — the long version Replied, post #8 · Research Methods › N-of-1 designs · 4 Jul 2026 · 1 like An n of one tells you about one person, which is the person you are most interested in. That is the whole value and it is not nothing. I would put a moderate confidence…
Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #23 · Practice › Side effects · 1 Jul 2026 · 4 likes The strongest argument against my own position on Muscle cramps, stated as well as I can state it, since nobody else has yet.
An 18-month record including the parts that went badly Replied, post #47 · Outcomes › Progress reports · 21 Jun 2026 · 1 like I had written a reply contradicting post #45 and deleted it. Here is what survived. Photographs at fixed intervals under fixed conditions are a better record of…
Peak-to-trough ratio at steady state for a weekly agent — the long version Replied, post #22 · Pharmacology › Pharmacokinetics · 10 Jun 2026 · 14 likes Half-life: semaglutide ≈ 165–184 hours (about a week). Tirzepatide ≈ 5 days. Liraglutide ≈ 13 hours. The half-life determines how much accumulation happens at steady…
Second pass at: Which categories are strict and which are relaxed, honestly Replied, post #67 · Start Here › Welcome · 1 Jun 2026 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Reference intervals: how they are constructed and why one in twenty flags — does this… Started this topic · Clinical › Bloodwork · 29 May 2026 · 7 likes Asking directly, because I could not find a straight answer: Reference intervals: how they are constructed and why one in twenty flags — does this still hold? A methods…
Hair shedding at month three: mechanism and time course — the long version Replied, post #16 · Practice › Side effects · 24 May 2026 · 0 likes Delayed gastric emptying: the mechanism behind much of the gastrointestinal side-effect profile. At extreme magnitudes, severe gastroparesis is a rare but serious…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #44 · Devices › Syringes & needles · 18 May 2026 · 21 likes Adding the measurement that post #41 says would settle it. What I want from this 0.3 ml versus 0.5 ml thread is the list of things that would need to be true for the…
Coming back to: Time to steady state after a dose increase Replied, post #53 · Pharmacology › Pharmacokinetics · 14 May 2026 · 8 likes This follows post #51 rather than contradicting it. Accumulation at steady state: with a week-long half-life, steady-state concentration is reached around 4 to 5…
Follow-up: Search filters: what is missing Replied, post #84 · Meta › Site feedback · 23 Apr 2026 · 9 likes Reporting rather than recommending, on Search filters. What happened is above. Whether it should have is a different question and not one I am qualified to answer.
Pinch or no pinch, and how needle length changes the answer — the long version Replied, post #46 · Practice › Administration · 18 Apr 2026 · 13 likes Bleeding at the injection site: normal and usually minimal. A little blood at the needle site after withdrawal is not a reason to assume you lost a significant dose.…
Follow-up: I have no scientific background — can I still follow the analytics categories? Replied, post #8 · Start Here › Welcome · 11 Apr 2026 · 4 likes Second this, and I would have said it less carefully.
Revisiting: Drawing up with one needle and injecting with another Started this topic · Practice › Administration · 30 Mar 2026 · 40 likes Revisiting: Drawing up with one needle and injecting with another Writing it up because I had to work it out twice and would rather nobody else did. A practical…
Journal club: orforglipron phase 2 and the non-peptide question Replied, post #26 · Evidence › Journal club · 29 Mar 2026 · 11 likes The most useful thing anyone has posted about orforglipron phase 2 in this category was a table of what had been measured and by whom. That is what I would want again.
Reading a preclinical wound-healing model and its relevance to a human tendon — a second… Replied, post #42 · Compounds › Repair & healing peptides · 12 Mar 2026 · 2 likes Anecdote is the whole of the human evidence base here, and this community's convention is to say so rather than to aggregate anecdotes into something that sounds like…
Stepping down deliberately, and how to do it without losing progress Replied, post #71 · Practice › Dosing & titration · 9 Mar 2026 · 13 likes Adding the measurement that post #70 says would settle it. If you are stepping up mainly because the schedule says so rather than because the current dose has stopped…
Revisiting: Maintainer handover: how it works Replied, post #11 · Meta › Wiki maintenance · 22 Feb 2026 · 0 likes Picking up post #10: that is the part I would want checked first. Where the Maintainer handover reasoning breaks down for me is the step from the group result to the…
Storing lyophilised material long term: what governs the shelf life Replied, post #64 · Practice › Storage & stability · 14 Feb 2026 · 18 likes I had written a reply contradicting post #62 and deleted it. Here is what survived. Clarity is a weak test. A solution can lose a significant fraction of its active…
Revisiting: Sample handling between despatch and injection Replied, post #8 · Analytics › Method validation · 26 Jan 2026 · 15 likes Transfer between laboratories: a method can be transferred from one lab to another, but the receiving lab needs to demonstrate that they can achieve the same…
DXA precision and the least significant change for lean mass Replied, post #64 · Outcomes › Body composition · 12 Dec 2025 · 9 likes Resting metabolic rate: body composition affects metabolic rate. As fat mass decreases and lean mass is maintained, metabolic rate is usually maintained better than…
Lurking for two months before posting: was that the right call? Replied, post #72 · Start Here › Welcome · 21 Nov 2025 · 27 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Persistent vomiting and the threshold for seeking help Replied, post #68 · Safety › Adverse events · 13 Nov 2025 · 12 likes On post #66 — agreed on the reasoning, with one qualification. Severe gastrointestinal events: persistent vomiting, abdominal pain out of proportion, or signs of bowel…
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Replied, post #41 · Clinical › Special populations · 26 Oct 2025 · 18 likes Older adults would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.
Comparing my trajectory with the trial curves, carefully Replied, post #61 · Outcomes › Progress reports · 13 Oct 2025 · 0 likes Post #59 answers the question as asked. The question underneath it is different. Seasonal patterns: some people report weight loss is slower in winter than summer. Body…
Cagrilintide's dosing interval and the pharmacokinetics behind it Replied, post #63 · Compounds › Cagrilintide & amylin analogues · 4 Oct 2025 · 0 likes The pharmacokinetics support weekly dosing comfortably. What the pharmacokinetics do not tell you is the tolerable escalation rate, and that is the practical constraint…
What this community means by "a source", in practical terms Replied, post #115 · Start Here › Welcome · 15 Sep 2025 · 15 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Needle changes between doses on a reusable pen Replied, post #32 · Devices › Pens & autoinjectors · 1 Sep 2025 · 32 likes A pen that will not dial to the intended dose is usually telling you the cartridge does not contain enough for it. That is a designed behaviour rather than a fault.
Immortal time bias in a claims-database study Replied, post #32 · Evidence › Study critique · 28 Aug 2025 · 3 likes Reporting bias within a paper — a result in a figure that is absent from the abstract — is checkable and is worth checking when the claim matters. I would want the raw…
Are there stupid questions here? A staff answer, at length Replied, post #112 · Start Here › Welcome · 25 Aug 2025 · 25 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Second pass at: Why this subcategory is stricter about sourcing than most Replied, post #74 · Compounds › Secretagogues & GH axis · 18 Aug 2025 · 19 likes Injection-site reactions are reported more often in this family than for the incretins. Whether that is the compounds or the preparations they are typically supplied in…
Coming back to: Why quantitation is the hard part, not detection Replied, post #48 · Analytics › Home & field testing · 7 Aug 2025 · 4 likes The right question for any home test is: what physical quantity does it measure, and what would have to be true for that quantity to answer your question? Most…
A ten-fold dose error caught before injection — one year on Replied, post #11 · Devices › Syringes & needles · 1 Aug 2025 · 0 likes Worth separating two things that post #7 runs together. Source for the ten-fold dose error caught figure, since it was asked for. It is in the discussion rather than…
Are there stupid questions here? A staff answer, at length Replied, post #18 · Start Here › Welcome · 27 Jul 2025 · 9 likes The moderation log is public. Every staff action is logged with the rule cited and the reasoning stated. If you get moderated, the explanation is there and it is worth…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #23 · Analytics › HPLC & UHPLC · 25 Jul 2025 · 22 likes Reporting rather than recommending, on detection wavelength. What happened is above. Whether it should have is a different question and not one I am qualified to answer.
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #53 · Devices › Cold chain · 21 Jul 2025 · 2 likes Useful. I had the fact and not the reason, which turns out to be the important half.
Triple agonism: additive, synergistic, or neither? Replied, post #67 · Compounds › Retatrutide · 13 Jul 2025 · 11 likes Everything in post #63 holds. The case it does not cover is the one I have. Heart rate increased in a dose-dependent way in the phase 2 work. That is not a footnote —…
Reading a supplier's product description as a marketing document Replied, post #43 · Compounds › Other compounds · 10 Jul 2025 · 0 likes Narrowing post #42, because the general version has more than one answer. Thymosin alpha-1 has a regulatory history in several jurisdictions and a real clinical…
Revisiting: German, French and Dutch differences, compared Replied, post #40 · Regional › European Union · 2 Jul 2025 · 7 likes I have no financial interest in anything named in this thread and I want to say so before I comment on German, because it is the sort of subject where it matters.
Tirzepatide in type 2 diabetes: the SURPASS programme, summarised honestly Replied, post #119 · Compounds › Tirzepatide · 25 Jun 2025 · 24 likes The question underneath tirzepatide in type 2 diabetes is usually "how would I tell?" rather than "what is true?", and that one has a method attached to it. Write down…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #47 · Compounds › Oral incretins · 13 Jun 2025 · 0 likes Dose numbers for oral formulations are not comparable to injectable ones. The 14 mg oral dose is not equivalent to any injectable dose in the traditional comparison…
The CagriSema phase 2 paper and what a fixed combination buys — the long version Replied, post #43 · Compounds › Cagrilintide & amylin analogues · 8 Jun 2025 · 19 likes On post #39 — agreed on the reasoning, with one qualification. Cagrilintide alone is discussed less than in combination because the published data is almost entirely…
Journal club: SURMOUNT-1, read without the press release Replied, post #128 · Evidence › Journal club · 1 Jun 2025 · 1 like Clear enough that I do not think I have a follow-up, which is unusual.
Pregnancy as an absolute contraindication Replied, post #100 · Safety › Contraindications · 20 May 2025 · 2 likes Anyone posting a contraindication claim should include the source. Without one it circulates and hardens. I would put a moderate confidence on that and no more.
Revisiting: Filter needles: when they help and what they cost you Replied, post #12 · Devices › Syringes & needles · 13 Apr 2025 · 8 likes Everything in post #10 holds. The case it does not cover is the one I have. Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm…
[2026 update] Cardiovascular risk: reading the outcome trials as a set Replied, post #16 · Clinical › Comorbidities · 11 Apr 2025 · 0 likes Building on post #14 rather than restating it. Cardiovascular risk is a good example of a question where the honest answer is boring and the interesting answers are…
Second pass at: A history of disordered eating: proceeding carefully Replied, post #32 · Wellbeing › Mental health · 11 Apr 2025 · 19 likes Picking up post #29: that is the part I would want checked first. Substance use: if someone has a history of substance use, appetite suppression and weight loss can…
Documenting a supplier's response to a discrepancy — does this still hold? Started this topic · Sourcing › Vendor reports · 16 Mar 2025 · 22 likes Documenting a supplier's response to a discrepancy — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below.…
BPC-157: what the rodent literature actually shows, and what it does not — a second… Replied, post #21 · Compounds › Repair & healing peptides · 7 Mar 2025 · 21 likes Something worth flagging about BPC-157: the strongest-sounding claims in this thread are the ones with no source attached, which is the usual pattern and not a…
Consistent declarations and why they matter more than clever ones Replied, post #143 · Sourcing › Logistics · 7 Mar 2025 · 33 likes That is the distinction I keep failing to hold on to. Written down now.
Canadian access and provincial variation Replied, post #63 · Regional › North America · 7 Feb 2025 · 33 likes The public assessment documents published at approval are free, detailed and largely unread here. I would want a second opinion before relying on that.
Research-use-only status: what it means legally and practically — a second dataset Replied, post #78 · Compounds › Other compounds · 1 Feb 2025 · 8 likes Where I part company with post #75, and it is a narrow parting. Counterpoint on Research-use-only status, offered without confidence: the same observation is consistent…
What a seizure notice actually says Replied, post #28 · Sourcing › Logistics · 28 Jan 2025 · 0 likes Building on post #26 rather than restating it. What I would check first on seizure notice is whether the thing being measured moved or whether the way of measuring it…
[2026 update] New subcategory: rationale and scope Replied, post #158 · Meta › Announcements · 17 Jan 2025 · 23 likes This is the first time the answer has come with its own limits attached. Appreciated.
Coming back to: When to suspect the method rather than the sample Replied, post #79 · Analytics › Method validation · 15 Dec 2024 · 0 likes Following this. I have the same question and no better information than the first post.
Journal club: SURMOUNT-1, read without the press release Replied, post #23 · Evidence › Journal club · 5 Dec 2024 · 7 likes An observation about SURMOUNT-1 that I cannot explain and am posting anyway, on the principle that unexplained observations are more useful public than private.
Second pass at: A field-by-field walk through a certificate of analysis Replied, post #130 · Analytics › COA interpretation · 26 Nov 2024 · 4 likes I had written a reply contradicting post #128 and deleted it. Here is what survived. The distinction between release testing and characterisation is one industrial…
TB-500 and thymosin beta-4: the fragment versus the protein — does this still hold? Replied, post #6 · Compounds › Repair & healing peptides · 21 Nov 2024 · 29 likes Where I part company with post #2, and it is a narrow parting. Two questions I would want answered before drawing anything from the TB-500 and thymosin beta-4 data…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #131 · Clinical › Comorbidities · 30 Oct 2024 · 5 likes Hypertension improvement: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.
Requesting a page: what makes a good request — what changed since Replied, post #134 · Documentation › Wiki requests · 13 Oct 2024 · 29 likes Post #132 and I disagree about the size of the effect, not about the direction. Request a new maintained page: if a question recurs, has a good marked solution, and…
Follow-up: A site rotation scheme that is easy enough to actually follow Replied, post #39 · Practice › Administration · 19 Sep 2024 · 0 likes Following this. I have the same question and no better information than the first post.
Second pass at: Sodium, potassium and magnesium when intake drops Replied, post #89 · Nutrition & Training › Hydration & electrolytes · 12 Sep 2024 · 17 likes Orthostatic symptoms: dizziness on standing after lying down can indicate dehydration or electrolyte depletion. Increasing fluids, salt, and potassium usually resolves…
Correlation in a self-tracked dataset: what it can support Replied, post #31 · Research Methods › Statistics · 21 Aug 2024 · 6 likes Post #30 is the version of this I will quote in future. One addition. Correlation: I would want to see the raw numbers rather than the summary before agreeing.…
The C-cell question: rodent findings and their human context — what changed since Replied, post #6 · Compounds › Semaglutide · 13 Aug 2024 · 5 likes I came in to disagree and I am leaving without a disagreement.
Coming back to: Purity assay versus content assay: two different numbers Replied, post #47 · Analytics › COA interpretation · 11 Aug 2024 · 21 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Oral contraceptives and delayed emptying: what the data shows Replied, post #19 · Practice › Interactions · 9 Jul 2024 · 23 likes Delayed gastric emptying is the mechanism behind most of the plausible interactions in this class: anything whose absorption depends on how quickly the stomach empties…
Blind submission and why it changes minds Replied, post #8 · Sourcing › Independent verification · 2 Jul 2024 · 16 likes Taking post #7 at face value and following it one step further. The version of blind submission that circulates here is a simplification of a simplification. It is not…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #7 · Practice › Dosing & titration · 31 May 2024 · 2 likes Where I have landed on four-week escalation interval, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise…