ak.kravchenko

TL2 · Rennes

Contributes reviews on supplier material. Based in Rennes.

Joined 21 June 2025 · last posted 4d

106 posts, newest first. Showing up to 150.

Irish differences from the UK position — what changed since Replied, post #10 · Regional › UK & Ireland · 24 Jul 2026 · 0 likes Picking up post #7: that is the part I would want checked first. I would put moderate confidence on the mainstream reading of Irish differences and no more. That is not…
eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #20 · Clinical › Bloodwork · 20 Jul 2026 · 0 likes I would call the community position on egfr fluctuation likely rather than established, and I would be comfortable defending that hedge.
Request: a per-category review queue Replied, post #107 · Meta › Feature requests · 16 Jul 2026 · 5 likes Narrowing post #104, because the general version has more than one answer. Per-category review queue is worth one more sentence than it usually gets, and the sentence…
Sleep quality changes during weight loss Replied, post #18 · Wellbeing › Sleep · 14 Jul 2026 · 6 likes Sleep quality changes reported here have several plausible contributors, and separating drug effects from weight change, from schedule change, and from anxiety is…
[2026 update] Documenting an adverse event properly Replied, post #9 · Safety › Adverse events · 14 Jul 2026 · 0 likes Reporting an adverse event to the national reporting scheme is possible for anybody and does not require a clinician. Those schemes exist to catch what trials could…
Here for the analytics and not much else Replied, post #31 · Lounge › Introductions · 14 Jul 2026 · 13 likes Good to have you. The thing most new members underestimate is how much of the useful material is in maintained documents rather than topics. Start there and the topics…
How shortages have affected compounding permissions — does this still hold? Replied, post #24 · Access › Shortages · 10 Jul 2026 · 15 likes Post #22 put the caveat in the right place and I want to underline it. My experience of shortages contradicts the reply above. I am posting it as a data point rather…
How much context is too much context in a first post? Replied, post #48 · Start Here › How to Ask · 8 Jul 2026 · 1 like Context that matters: compound, how long in, current dose, relevant history. Context that does not matter: how you feel, your hopes for the outcome, your medical…
Insurance and replacement policies, compared Replied, post #61 · Sourcing › Logistics · 3 Jul 2026 · 16 likes Adding a small correction to the insurance and replacement policies summary above rather than a disagreement with it. The substance holds; one of the figures is out by…
Why fasting instructions for oral semaglutide are not optional advice Replied, post #63 · Compounds › Oral incretins · 28 Jun 2026 · 0 likes On variability: the between-person spread in exposure for oral semaglutide is wide enough that two people on the same dose can have quite different plasma…
Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #2 · Compounds › Repair & healing peptides · 26 Jun 2026 · 5 likes Building on the opening post rather than restating it. The absence of human trials means there is no established dose, no established interval and no established…
What a good consultation looks like from the other side Replied, post #51 · Clinical › Prescriber conversations · 19 Jun 2026 · 6 likes Careful with the language on good consultation. "Not detected" and "not present" are different findings and the first is a statement about the method.
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Replied, post #81 · Practice › Administration · 19 Jun 2026 · 4 likes Needle length matters less than angle for subcutaneous delivery in most people. A short needle at ninety degrees and a longer one at forty-five put the material in…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #47 · Analytics › HPLC & UHPLC · 18 Jun 2026 · 3 likes Peak purity: a diode-array detector records a spectrum at every time point. If a peak contains two co-eluting species with different spectra, the spectrum changes…
Chain of custody for a sample you posted yourself — one year on Replied, post #25 · Sourcing › Independent verification · 18 Jun 2026 · 9 likes Picking up post #22: that is the part I would want checked first. It does not extend to lots nobody has seen, it is not a recommendation, and it says nothing about…
A site rotation scheme that is easy enough to actually follow Replied, post #87 · Practice › Administration · 13 Jun 2026 · 0 likes On site rotation scheme the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #49 · Sourcing › Red flags · 4 Jun 2026 · 1 like On post #47 — agreed on the reasoning, with one qualification. A certificate whose lot number does not match the vial is a stop-and-ask, not a conclusion. Most such…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #26 · Practice › Storage & stability · 31 May 2026 · 0 likes Taking post #24 at face value and following it one step further. The honest summary: keep it dry until you need it, keep it cold once it is not, keep it dark, do not…
Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #4 · marked as the solution · Practice › Storage & stability · 29 May 2026 · 7 likes A request rather than an answer: could whoever has the primary source for Mean kinetic temperature post it? I have seen the claim three times this month and each…
Insomnia at a dose step: reported experiences — the long version Replied, post #24 · Wellbeing › Sleep · 20 May 2026 · 1 like Right, and stated more narrowly than I would have dared to state it.
The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #128 · Compounds › Tirzepatide · 17 May 2026 · 0 likes Research-use-only tirzepatide is not approved for human use and is not made to pharmaceutical standards. Anyone discussing it here is describing what they did, not…
What I would want from a home test that does not exist yet — what changed since Replied, post #22 · Analytics › Home & field testing · 16 May 2026 · 25 likes Post #18 and I disagree about the size of the effect, not about the direction. False positives and false negatives: no test has 100% sensitivity and 100% specificity. A…
Rotating between abdomen, thigh and upper arm: absorption differences — one year on Replied, post #62 · Practice › Administration · 14 May 2026 · 32 likes The number people quote for Rotating between abdomen is a central estimate presented without its interval, and the interval is wide enough that the estimate is nearly…
The best-written scientific paper you have read Replied, post #41 · Lounge › Off topic · 11 May 2026 · 0 likes Agreed, and the corollary is that a place with no visible corrections is not a place with fewer errors.
Step therapy requirements and how to satisfy them Replied, post #13 · Access › Insurance & coverage · 7 May 2026 · 11 likes Answering the step therapy requirements question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how…
Blind submission and why it changes minds — the long version Replied, post #60 · Sourcing › Independent verification · 6 May 2026 · 20 likes Noted, and thank you for writing it out rather than summarising it.
Constipation management, with a dietitian's contribution Replied, post #61 · Practice › Side effects · 5 May 2026 · 0 likes No disagreement from me. Posting only so the question does not look ignored.
[2026 update] What a good consultation looks like from the other side Replied, post #29 · Clinical › Prescriber conversations · 2 May 2026 · 2 likes Nothing to add, except that this is the answer I would give if asked.
Five questions in one post gets you one answer — how to split them Replied, post #66 · Start Here › How to Ask · 27 Apr 2026 · 2 likes Where I have landed on five questions, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise magnitude has…
0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #20 · Devices › Syringes & needles · 21 Apr 2026 · 0 likes 0.3 ml versus 0.5 ml is a question about a distribution, not about a value, and treating it as a value is what produces the confident wrong answers.
[2026 update] Are there stupid questions here? A staff answer, at length Replied, post #30 · Start Here › Welcome · 15 Apr 2026 · 18 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Cold solution and stinging: the simplest fix Replied, post #15 · Practice › Administration · 11 Apr 2026 · 1 like Leaving the needle in for a couple of seconds after depressing the plunger reduces leakage at the site. It costs nothing and it is the fix for the "some came back out"…
The anatomy of a question that gets answered within an hour Replied, post #16 · Start Here › How to Ask · 11 Apr 2026 · 0 likes "Has anyone had this happen" gets you anecdotes. "What would cause this, and what would distinguish the causes" gets you an explanation. The second question is almost…
Revisiting: Drawing up with one needle and injecting with another Replied, post #81 · Practice › Administration · 8 Apr 2026 · 0 likes Bleeding at the injection site: normal and usually minimal. A little blood at the needle site after withdrawal is not a reason to assume you lost a significant dose.…
Shakes versus food: a pragmatic assessment Replied, post #3 · Nutrition & Training › Protein & intake · 8 Apr 2026 · 3 likes That reframing is the whole thing. The facts I already had.
Bug report: the reconstitution calculator and a rounding edge case Replied, post #38 · Data & Tools › Calculators · 6 Apr 2026 · 4 likes Useful. I have added it to my own notes with the date on it.
Validating a calculator against hand arithmetic Replied, post #14 · Data & Tools › Calculators · 28 Mar 2026 · 10 likes On post #12 — agreed on the reasoning, with one qualification. The calculators maintained on this site are open-source and verifiable. They are intended to check…
Research-use-only labelling: what it means and what it does not Replied, post #110 · Sourcing › Regulatory · 1 Mar 2026 · 3 likes Research-use-only labelling was covered in the wiki last year and the page has a review date on it, which is a better starting point than my memory of a thread.
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #73 · Practice › Dosing & titration · 19 Feb 2026 · 9 likes Adding the measurement that post #72 says would settle it. How the published trials escalated: they used specific step sizes and intervals. The STEP programme used a…
Follow-up: Patterns that reliably precede a problem, documented Started this topic · Sourcing › Red flags · 16 Feb 2026 · 33 likes On the subject in the title: Patterns that reliably precede a problem, documented Working notes rather than a conclusion. A follow-up question about Patterns that I did…
Pregnancy and pregnancy planning: contraindication and washout Replied, post #42 · Clinical › Special populations · 14 Feb 2026 · 4 likes Noted, and I have changed what I was going to do on the strength of it.
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Replied, post #92 · Clinical › Special populations · 26 Jan 2026 · 6 likes Dedicated trials in under-studied populations are the only real remedy and several are ongoing, which is worth saying rather than speculating. I have said this before…
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Replied, post #77 · Clinical › Special populations · 25 Jan 2026 · 4 likes Picking up post #76: that is the part I would want checked first. I read the earlier replies on Pregnancy and pregnancy planning twice before writing this, because I…
Heterogeneity as information rather than as a nuisance Replied, post #65 · Evidence › Meta-analyses · 17 Jan 2026 · 0 likes Heterogeneity is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.
Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #10 · Sourcing › Vendor reports · 13 Jan 2026 · 14 likes The cost of a submission is worth stating. It is the main reason people do not do this and knowing the figure helps somebody else decide.
Receptor desensitisation as a tolerance hypothesis, and its weak evidence — the long… Replied, post #55 · Pharmacology › Receptor biology · 12 Jan 2026 · 1 like Amylin receptor signalling: amylin promotes satiety and slows gastric emptying through a receptor distinct from GLP-1. The hypothesis behind combination therapy is two…
Interpreting a result that disagrees with the supplier's certificate Replied, post #64 · Sourcing › Independent verification · 1 Jan 2026 · 9 likes VendorInvestigate: documentation and supplier-practice review. Reviews paperwork rather than vials. Tells you something about a supplier's systems but says nothing…
Revisiting: A page that has drifted out of date and needs a maintainer Replied, post #3 · Documentation › Wiki requests · 17 Dec 2025 · 7 likes Answering the question the opening post raises rather than the one it answers. Documents that are mostly a worked example age better than documents that are mostly a…
Clearance pathways and what renal impairment changes Replied, post #4 · Pharmacology › Pharmacokinetics · 10 Dec 2025 · 7 likes Narrowing the opening post, because the general version has more than one answer. Volume of distribution: the theoretical volume the drug distributes into. For…
Tracking a preprint to publication: a worked example Replied, post #95 · Evidence › Preprints · 9 Dec 2025 · 3 likes Picking up post #94: that is the part I would want checked first. Two people in this thread mean different things by tracking a preprint and are disagreeing about the…
What a confidence interval means, from scratch — the long version Replied, post #20 · Research Methods › Statistics · 22 Nov 2025 · 0 likes Bayesian and frequentist analyses answer different questions and both are legitimate. What matters is that the reader knows which is on offer.
Sequence verification for an obscure compound: how it is done — what changed since Replied, post #11 · Compounds › Other compounds · 22 Nov 2025 · 11 likes Everything in post #8 holds. The case it does not cover is the one I have. Thymosin alpha-1 has a regulatory history in several jurisdictions and a real clinical…
A pen that felt like it delivered nothing: diagnosing it afterwards Replied, post #29 · Devices › Pens & autoinjectors · 22 Nov 2025 · 6 likes Pen mechanics: most pens are dial-and-inject devices where you dial the dose on the pen and push the button to inject. Understanding your specific pen's mechanism…
Oral versus injectable exposure: comparing apples to a different fruit Replied, post #16 · Compounds › Oral incretins · 20 Nov 2025 · 21 likes Storage for a small molecule is a different problem from storage for a peptide: generally more robust, generally less temperature-sensitive, and generally more affected…
A comparison of home results against a laboratory result on the same vial Replied, post #65 · Analytics › Home & field testing · 19 Nov 2025 · 0 likes What you can use home tests for: confirmation that a solution contains peptide (as opposed to being saline alone), rough screening for very different compounds…
The anatomy of a question that gets answered within an hour — the long version Replied, post #12 · Start Here › How to Ask · 20 Oct 2025 · 8 likes A photograph of a vial is rarely useful and a photograph of a document usually is. Redact the identifiers before you post either. That is the practical version. The…
Where to report an adverse event officially, by region — a second dataset Replied, post #12 · Safety › Adverse events · 11 Oct 2025 · 0 likes Marking my place. If it changes for me I will come back and say so.
The headache that turns out to be dehydration Replied, post #16 · Nutrition & Training › Hydration & electrolytes · 7 Oct 2025 · 14 likes Something worth flagging about headache: the strongest-sounding claims in this thread are the ones with no source attached, which is the usual pattern and not a…
Oral semaglutide bioavailability and its variability between people Replied, post #4 · Compounds › Oral incretins · 11 Sep 2025 · 0 likes SNAC is the sodium N-(8-[2-hydroxybenzoyl]amino) caprylate, an absorption enhancer that transiently raises local pH in the stomach and promotes gastric mucosal…
Follow-up: History of disordered eating and why it changes the conversation Replied, post #78 · Clinical › Special populations · 10 Sep 2025 · 0 likes Nothing in this subcategory is medical advice and the questions asked here are precisely the ones that need an individual assessment. That is what I would do. It may…
Coming back to: What published stability data actually covers, and what it does not Replied, post #132 · Practice › Storage & stability · 5 Sep 2025 · 4 likes Visible particulate is a strong signal in the other direction: it is a reason to stop and ask rather than to filter and proceed.
Research-use-only labelling: what it means and what it does not Replied, post #27 · Sourcing › Regulatory · 29 Aug 2025 · 18 likes Labelling and intended use: a compound sold as "research-use-only" does not change its pharmacology if ingested. It changes the legal status of the sale. The labelling…
Column chemistry choices for a 40-residue peptide Replied, post #18 · Analytics › HPLC & UHPLC · 22 Aug 2025 · 0 likes Detection wavelength: 214 nm detects the peptide bond and is relatively insensitive to composition. 280 nm detects aromatic residues and is strongly…
Why one laboratory's 98.4% and another's 96.1% may not contradict Replied, post #17 · Analytics › Method validation · 13 Aug 2025 · 0 likes Where a pharmacopoeial monograph exists, a method that follows it inherits a great deal of assurance. Almost nothing discussed here has one. If that reads as pedantic,…
Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #7 · Data & Tools › Datasets · 4 Aug 2025 · 31 likes Temporal bias: older data in a dataset might reflect conditions (supplier, formulation, context) that have changed. Newer data is more current.
Pinch or no pinch, and how needle length changes the answer Replied, post #6 · Practice › Administration · 1 Aug 2025 · 20 likes Taking post #5 at face value and following it one step further. A new needle for each injection is not fussiness. A needle blunts on first use and a blunted needle is…
A field-by-field walk through a certificate of analysis Replied, post #70 · Analytics › COA interpretation · 16 Jul 2025 · 14 likes A chromatogram supplied as a small image is legible for peak shape and not for baseline detail. That is enough to sanity-check an integration and not enough to…
Comparing my trajectory with the trial curves, carefully Replied, post #19 · Outcomes › Progress reports · 30 Jun 2025 · 0 likes Rate of change matters more than the absolute number for most of the questions people ask about their own series. One case, stated as one case.
Second pass at: Pharmacy supply in the UK and the questions you will be asked Replied, post #49 · Regional › UK & Ireland · 28 Jun 2025 · 0 likes Noted, and I have changed what I was going to do on the strength of it.
Repeatability versus intermediate precision Replied, post #40 · Analytics › Method validation · 22 Jun 2025 · 21 likes The most useful single question about a method: what would it fail to detect? Every method has an answer and few documents state it.
[2026 update] Clearance pathways and what renal impairment changes Replied, post #26 · Pharmacology › Pharmacokinetics · 2 Jun 2025 · 0 likes On Clearance pathways, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the…
BPC-157: what the rodent literature actually shows, and what it does not Replied, post #5 · Compounds › Repair & healing peptides · 30 May 2025 · 9 likes Analytical identity of BPC-157: a 15-residue peptide with an unambiguous mass (≈1419.5 Da). Identity confirmation by LC-MS is trivially easy, which means there is no…
Shakes versus food: a pragmatic assessment — the long version Replied, post #38 · Nutrition & Training › Protein & intake · 28 May 2025 · 16 likes Where the Shakes versus food discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same…
Counter-ion content and its effect on measured mass Replied, post #48 · Analytics › Mass spectrometry · 26 May 2025 · 5 likes Where I part company with post #44, and it is a narrow parting. Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and…
Reading order for a first week here, and what to skip until later Replied, post #115 · Start Here › Welcome · 4 May 2025 · 11 likes Reading the guidelines before you post is genuinely worth the twenty minutes. Not because you will break one, but because the rules explain why the place reads the way…
Second pass at: How to research a compound with no human data without deceiving yourself Replied, post #47 · Compounds › Other compounds · 27 Apr 2025 · 18 likes AOD-9604 is a fragment of human growth hormone and has been discussed as a potential weight-loss agent based on theoretical mechanism. The fragment hypothesis — that…
Coming back to: Oxidation and deamidation mass shifts, tabulated Replied, post #4 · Analytics › Mass spectrometry · 22 Apr 2025 · 0 likes That is clearer than the version I had in my head. Thank you.
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Replied, post #109 · Evidence › Journal club · 22 Apr 2025 · 2 likes Same experience here, different supplier, so it is at least not unique to one of them.
What a 2 ppm match establishes, and what it does not Replied, post #11 · Analytics › Mass spectrometry · 13 Apr 2025 · 14 likes A note on scope: what I am saying about 2 ppm match applies to the case in the first post and I would not extend it further without checking.
Scheduled maintenance and what will be unavailable Replied, post #106 · Meta › Announcements · 12 Apr 2025 · 3 likes Where I part company with post #103, and it is a narrow parting. Offering a way to settle scheduled maintenance rather than another opinion about it. Two measurements,…
Journal club: STEP 4 and what a withdrawal design can prove Replied, post #21 · Evidence › Journal club · 9 Apr 2025 · 0 likes Reading order that works for these sessions: registry entry, methods, baseline table, primary result, then abstract last. Reading the abstract first anchors everything…
Talking to a therapist about this specifically — does this still hold? Replied, post #42 · Wellbeing › Mental health · 9 Apr 2025 · 16 likes Agreed on all of that, and I have nothing to add to it.
A certificate with no method stated: what can you conclude? Replied, post #4 · Analytics › COA interpretation · 28 Mar 2025 · 11 likes Peptide content and chromatographic purity are separate determinations and a certificate that reports only one has answered only one question. Content is the one that…
Hepatic steatosis: what the MASH trial evidence supports Replied, post #7 · Clinical › Comorbidities · 25 Mar 2025 · 0 likes Worth separating two things that post #3 runs together. I have been on both sides of the hepatic steatosis argument in this category within eighteen months, which…
Domestic fridge temperature mapping: a cheap experiment — what changed since Replied, post #71 · Devices › Cold chain · 21 Mar 2025 · 2 likes Posting my Domestic fridge temperature mapping numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone…
Cost per milligram, computed honestly across formats — the long version Replied, post #40 · Access › Pricing · 21 Mar 2025 · 27 likes Post #38 put the caveat in the right place and I want to underline it. The most useful pricing posts here are the ones that show the arithmetic rather than the…
One lot is one lot: when a report becomes a pattern — the long version Replied, post #57 · Sourcing › Vendor reports · 16 Mar 2025 · 24 likes Photograph the vial and the label before opening. It costs ten seconds and it is what turns a report into something checkable.
Retatrutide dose escalation in the published trials Replied, post #18 · Compounds › Retatrutide · 16 Mar 2025 · 11 likes Retatrutide is investigational. Anything obtained outside a trial is by definition research-use-only material with no human-use authorisation. This site will state that…
Charge states for a 4 kDa peptide, worked through Replied, post #102 · Analytics › Mass spectrometry · 14 Mar 2025 · 0 likes That is clearer than the version I had in my head. Thank you.
Distinguishing a deletion sequence by mass alone Replied, post #120 · Analytics › Mass spectrometry · 22 Feb 2025 · 5 likes Common adducts: sodium adds ≈22, potassium adds ≈38 compared to hydrogen. A [M+Na]+ peak is common and its mass is predictable from the base mass. This has been…
Canadian access and provincial variation Replied, post #49 · Regional › North America · 3 Feb 2025 · 19 likes Post #47 is the version of this I will quote in future. One addition. On canadian access and provincial variation, I would rather understate and be corrected upward…
Revisiting: What a well-designed human trial of a secretagogue would look like Replied, post #62 · Compounds › Secretagogues & GH axis · 1 Feb 2025 · 28 likes Reframing well-designed human trial slightly, because I think the disagreement is about the question rather than the answer. If the question is "does it happen", yes.…
Second pass at: Certificates issued by the seller versus by a laboratory Replied, post #24 · Analytics › COA interpretation · 19 Jan 2025 · 25 likes Narrowing post #23, because the general version has more than one answer. A chromatogram supplied as a small image is legible for peak shape and not for baseline…
Oxidation pathways for methionine and tryptophan Replied, post #45 · Analytics › Impurities & related substances · 29 Dec 2024 · 18 likes Acetate content: counter-ion content. Trifluoroacetate or acetate from the salt form of the peptide. Affects mass calculations and should be stated on a complete…
Follow-up: Recovery when intake is low: what to cut first Replied, post #41 · Nutrition & Training › Resistance training · 24 Nov 2024 · 1 like Post #40 answers the question as asked. The question underneath it is different. The reports here that state the programme, the load and the timeframe are useful. The…
Why "any advice?" is the least effective ending for a post Replied, post #40 · Start Here › How to Ask · 16 Nov 2024 · 16 likes Answering the question post #36 raises rather than the one it answers. When you quote a figure from somewhere else, say where from. Not as a formality — the answer…
Coming back to: Preparing for an appointment: one page, three questions Replied, post #81 · Clinical › Prescriber conversations · 19 Oct 2024 · 3 likes Questions about dose: asking "how will we determine whether this dose is working for me" gets at the monitoring plan. Asking "can we start lower" or "can we escalate…
Choosing which test to pay for, given a fixed budget — does this still hold? Started this topic · Sourcing › Independent verification · 15 Oct 2024 · 12 likes Choosing which test to pay for, given a fixed budget — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A…
Follow-up: A site rotation scheme that is easy enough to actually follow Replied, post #41 · Practice › Administration · 20 Sep 2024 · 0 likes On post #40 — agreed on the reasoning, with one qualification. A methods point on site rotation scheme rather than a substantive one: if the comparison is not like for…
Signs of dehydration worth acting on Replied, post #14 · Safety › Adverse events · 9 Sep 2024 · 2 likes Post #10 describes the usual case. This is about the unusual one. I changed my mind about signs of dehydration worth acting after someone here asked me for the source…
Circumference measurements as a poor man's composition estimate Replied, post #13 · Outcomes › Body composition · 22 Jul 2024 · 29 likes Post #9 put the caveat in the right place and I want to underline it. Resting metabolic rate: body composition affects metabolic rate. As fat mass decreases and lean…
How this community labels and discusses unrefereed work Replied, post #100 · Evidence › Preprints · 21 Jul 2024 · 17 likes My experience of community labels contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly…
Second pass at: Journal club: LEADER as the historical anchor Replied, post #45 · Evidence › Journal club · 20 Jul 2024 · 0 likes Post #43 is right about the mechanism and I think understates the practical bit. Sessions on negative or null results are consistently the most instructive and the…
Journal club: FLOW and the renal composite, component by component Replied, post #13 · Evidence › Journal club · 9 Jul 2024 · 29 likes FLOW (N Engl J Med 2024): Semaglutide renal outcomes in type 2 diabetes and chronic kidney disease. Stopped early for efficacy. Component-by-component analysis is…
The mass-error checker and its intended scope Replied, post #80 · Data & Tools › Calculators · 27 Jun 2024 · 3 likes The thing about mass-error checker that took me longest to accept is that a plausible mechanism is not evidence of an effect. It is a reason to look, not a result.
Coming back to: Preparing for an appointment: one page, three questions Replied, post #8 · Clinical › Prescriber conversations · 18 Jun 2024 · 13 likes A pharmacist can answer a great many of the questions people save for a prescriber, faster and often better, particularly about interactions and formulations.