v.malinowski

TL2 · Curitiba

Contributes reviews on supplier material. Based in Curitiba.

Joined 26 April 2025 · last posted 10d

103 posts, newest first. Showing up to 150.

What is genuinely unknown about long-term amylin agonism Replied, post #51 · Compounds › Cagrilintide & amylin analogues · 18 Jul 2026 · 1 like Where I part company with post #50, and it is a narrow parting. Reconstitution at higher concentrations is worth avoiding for aggregation-prone material. The published…
How shortages have affected compounding permissions Replied, post #36 · Access › Shortages · 13 Jul 2026 · 0 likes On post #34 — agreed on the reasoning, with one qualification. Practical note on shortages: write down what you expect before you look. The number of times I have found…
Follow-up: Reading an interaction checker output critically Replied, post #45 · Practice › Interactions · 13 Jul 2026 · 8 likes Post #42 put the caveat in the right place and I want to underline it. Insulin interaction: semaglutide and tirzepatide are not contraindicated with insulin but the…
Osteoarthritis and mechanical versus metabolic improvement — one year on Replied, post #53 · Clinical › Comorbidities · 13 Jul 2026 · 0 likes Nobody has said the unglamorous part of Osteoarthritis and mechanical versus metabolic yet, so: most of the variation is explained by things that are boring to write…
Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #27 · Compounds › Secretagogues & GH axis · 7 Jul 2026 · 0 likes Evidence quality in the secretagogue literature is honestly weaker than in the incretin literature. Large randomised controlled trials are rare. Most evidence is…
Submitting a sample: the process end to end Replied, post #59 · Sourcing › Independent verification · 5 Jul 2026 · 3 likes A note on scope: what I am saying about submitting a sample applies to the case in the first post and I would not extend it further without checking.
Private prescribing in the UK: what is actually involved Replied, post #55 · Regional › UK & Ireland · 4 Jul 2026 · 0 likes What would change my mind on private prescribing is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather…
I joined for one answer and stayed for a year — what changed my mind Replied, post #36 · Start Here › Welcome · 22 Jun 2026 · 14 likes Reading the guidelines before you post is genuinely worth the twenty minutes. Not because you will break one, but because the rules explain why the place reads the way…
Tracking intake honestly when appetite is absent Replied, post #58 · Nutrition & Training › Protein & intake · 13 Jun 2026 · 8 likes The arithmetic in post #55 is right; the assumption feeding it is the part to check. Tracking intake has a well-known answer and a correct answer, and the interesting…
What I would want from a home test that does not exist yet Replied, post #8 · Analytics › Home & field testing · 11 Jun 2026 · 11 likes A home refractometer is not measuring what people hope it is measuring in these preparations, and the readings are dominated by everything other than the peptide. The…
Sample size intuition for a personal experiment — does this still hold? Replied, post #31 · Research Methods › Statistics · 9 Jun 2026 · 4 likes On Sample size intuition: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any…
A reconstituted vial's beyond-use date and the reasoning behind common figures Replied, post #110 · Practice › Storage & stability · 9 Jun 2026 · 15 likes Published stability data applies specifically to the formulation studied, under the specific conditions stated. It does not automatically transfer to something…
Shoulders, tangent skims, and defensible integration Replied, post #7 · Analytics › HPLC & UHPLC · 9 Jun 2026 · 10 likes A chromatogram image at a resolution where you can see peak shape but not baseline detail is worth having and is not the same as the data. Ask for the integration table…
Injecting into an area that has become firm: why not to Replied, post #21 · Practice › Administration · 6 Jun 2026 · 1 like Worth separating two things that post #17 runs together. If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels…
A certificate whose chromatogram axes do not match its stated method — one year on Replied, post #26 · Sourcing › Red flags · 3 Jun 2026 · 20 likes Post #25 is right about the mechanism and I think understates the practical bit. Trying to state the certificate whose chromatogram axes position in a way that someone…
A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #62 · Practice › Reconstitution · 28 May 2026 · 0 likes Reconstituting a multi-strength kit: if a kit contains 5 mg, 10 mg, 15 mg vials and you are reconstituting all of them, writing the concentration on each vial in…
Personal or family history of medullary thyroid carcinoma — what changed since Replied, post #50 · Safety › Contraindications · 25 May 2026 · 4 likes Somebody's condition being on a list does not settle the decision, and somebody's condition being absent from one does not either.
Coming back to: A structured critique template this community uses Replied, post #14 · Evidence › Study critique · 18 May 2026 · 0 likes Adding a null result on structured critique template. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.
Molecular mass of semaglutide and why the figure differs between sources Replied, post #57 · Compounds › Semaglutide · 16 May 2026 · 0 likes The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it…
Why this subcategory is stricter about sourcing than most Replied, post #28 · Compounds › Secretagogues & GH axis · 10 May 2026 · 31 likes I read post #26 twice before replying, because I had assumed the opposite. On analysis: these are short peptides and generally straightforward chromatographically,…
Books and papers worth reading that are not about this at all — one year on Started this topic · Lounge › Off topic · 10 May 2026 · 5 likes Books and papers worth reading that are not about this at all — one year on — setting out what I have, and where I think it stops being reliable. Reading back through…
Follow-up: Search filters: what is missing Replied, post #92 · Meta › Site feedback · 3 May 2026 · 4 likes Confirming post #91 from a second method, which matters more than confirming it from a second person. Feedback on the trust-level page: it explains what each level…
[2026 update] Regional warehouse stock versus direct despatch Replied, post #57 · Sourcing › Logistics · 1 May 2026 · 0 likes One caution on Regional warehouse stock versus direct: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work…
Subgroup analyses: pre-specified versus discovered — a second dataset Replied, post #56 · Evidence › Trials · 23 Apr 2026 · 0 likes Post #55 is the version of this I will quote in future. One addition. A treatment-policy estimand asks what happens to people assigned to a strategy, including those…
Price changes over 2025 and 2026, tabulated and dated — does this still hold? Replied, post #151 · Access › Pricing · 19 Apr 2026 · 31 likes Adding the boring version of Price changes, because the interesting version keeps getting posted and the boring one is usually right. Check the ordinary explanations,…
Publication bias detection and its low power — does this still hold? Replied, post #21 · Evidence › Meta-analyses · 2 Apr 2026 · 10 likes Double extraction with disagreement resolution is standard and is worth checking for, because single extraction errors are common and non-random. Happy to be the one…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #51 · Practice › Storage & stability · 27 Feb 2026 · 1 like Agreed on all of that, and I have nothing to add to it.
[2026 update] Confounding by indication, explained with a concrete example Replied, post #79 · Evidence › Study critique · 23 Feb 2026 · 16 likes The pre-specified endpoint being a weaker proxy than you would like is a real criticism. It is a smaller one than saying the result was chosen after the fact. I have…
Pharmacy supply in the UK and the questions you will be asked Replied, post #48 · Regional › UK & Ireland · 20 Feb 2026 · 5 likes Post #44 put the caveat in the right place and I want to underline it. Clinical guidance published for prescribers is public and answers most eligibility questions here…
Stepping down deliberately, and how to do it without losing progress Replied, post #61 · Practice › Dosing & titration · 19 Feb 2026 · 25 likes Titrating on tolerability rather than on the calendar: some people escalate when they tolerate a dose well, others escalate on the prescribed schedule regardless. The…
When a dose reduction is the correct response to a side effect Started this topic · Practice › Dosing & titration · 15 Feb 2026 · 0 likes When a dose reduction is the correct response to a side effect — that is the question, and I have not found it answered plainly anywhere I have looked. I have read the…
Why "dose equivalence" between different incretin analogues is a weak concept Replied, post #9 · Practice › Dosing & titration · 14 Feb 2026 · 2 likes That matches what I have seen, for whatever a single anecdote is worth.
Seven-day rolling means and why weekly readings mislead — one year on Replied, post #20 · Outcomes › Progress reports · 8 Feb 2026 · 3 likes Nothing here is medical advice and a progress report is a description of what happened to one person under uncontrolled conditions.
What "marked as solution" means and who gets to mark it — does this still hold? Replied, post #36 · Start Here › Welcome · 28 Jan 2026 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Replied, post #10 · Clinical › Special populations · 20 Jan 2026 · 0 likes Bookmarking this. I will come back when I have something worth adding.
Distinguishing expected GI effects from something that needs urgent attention Replied, post #15 · Practice › Side effects · 2 Jan 2026 · 31 likes The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
Vomiting: when it is expected and when it is a reason to stop Started this topic · Practice › Side effects · 25 Dec 2025 · 9 likes Posting this under the heading it deserves: Vomiting: when it is expected and when it is a reason to stop Everything below is what sits behind that. Reporting something…
Second pass at: Adsorptive losses at low concentration, and why dilute solutions are… Replied, post #6 · Practice › Storage & stability · 24 Dec 2025 · 28 likes I had written a reply contradicting post #4 and deleted it. Here is what survived. On Adsorptive losses I would separate what is worth knowing from what is worth acting…
Lurking for two months before posting: was that the right call? Replied, post #47 · Start Here › Welcome · 19 Nov 2025 · 13 likes The compound and evidence pages are updated regularly and they are worth reading when you are new. They answer the meta questions like "do we have data on this" and…
Persistent vomiting and the threshold for seeking help Replied, post #72 · Safety › Adverse events · 19 Nov 2025 · 16 likes Post #69 answers the question as asked. The question underneath it is different. Medullary thyroid carcinoma is the reason these compounds are contraindicated in people…
Why an oral GLP-1 agonist is a formulation achievement more than a chemistry one Replied, post #50 · Compounds › Oral incretins · 18 Nov 2025 · 8 likes Confirming post #47 from a second method, which matters more than confirming it from a second person. Dose numbers for oral formulations are not comparable to…
Comparing my trajectory with the trial curves, carefully Replied, post #76 · Outcomes › Progress reports · 15 Nov 2025 · 13 likes Narrowing post #74, because the general version has more than one answer. If a pattern survives a rolling-mean treatment it is worth explaining. Most do not, and that…
Why "add 2 mL" is not an instruction Replied, post #6 · Practice › Reconstitution · 8 Nov 2025 · 22 likes Picking up post #3: that is the part I would want checked first. Preservative effectiveness is tested against a defined microbial challenge under defined conditions. It…
Common supplements people ask about, assessed one at a time — a second dataset Started this topic · Practice › Interactions · 21 Oct 2025 · 60 likes Posting this under the heading it deserves: Common supplements people ask about, assessed one at a time — a second dataset Everything below is what sits behind that. A…
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #87 · Start Here › Welcome · 20 Oct 2025 · 31 likes If you are not sure which subcategory a question belongs in, post it in the closest one. A moderator will move it, the move is logged, and nothing bad happens to you.
SURMOUNT-4 and what withdrawal data does and does not tell an individual — one year on Replied, post #22 · Compounds › Tirzepatide · 19 Oct 2025 · 1 like I had written a reply contradicting post #20 and deleted it. Here is what survived. Practical answer on SURMOUNT-4, since the theoretical one is upthread: do the…
"Greater than or equal to 99%" as a specification rather than a result Replied, post #50 · Analytics › COA interpretation · 11 Oct 2025 · 3 likes What fields matter on a certificate: lot number matching the vial, test date, the analytical method stated specifically, the measured result as a number, and the…
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Replied, post #31 · Clinical › Special populations · 5 Oct 2025 · 11 likes Post #30 is right about the mechanism and I think understates the practical bit. Practical experience of Older adults, offered as one case with the conditions stated,…
Pinch or no pinch, and how needle length changes the answer Replied, post #79 · Practice › Administration · 25 Sep 2025 · 14 likes A methods point on pinch rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.
Hypertension improvement and when medication needs revisiting Replied, post #70 · Clinical › Comorbidities · 19 Sep 2025 · 0 likes Adding the measurement that post #69 says would settle it. Nothing here is medical advice and clinicians posting in this subcategory say so on their own account rather…
Lyophilisation and why the cake looks the way it does Replied, post #16 · Pharmacology › Formulation chemistry · 15 Sep 2025 · 6 likes Benzyl alcohol as a preservative is also a solubiliser for some peptides, which is an incidental property that occasionally matters.
What this community means by "a source", in practical terms Replied, post #105 · Start Here › Welcome · 8 Sep 2025 · 3 likes Reading the guidelines before you post is genuinely worth the twenty minutes. Not because you will break one, but because the rules explain why the place reads the way…
Aggregated purity results across four services, with caveats — a second dataset Replied, post #20 · Data & Tools › Datasets · 7 Sep 2025 · 7 likes Reading back through, this was answered upthread and I missed it. My fault.
A parcel that arrived warm: a decision process, not a verdict Replied, post #20 · Practice › Storage & stability · 1 Sep 2025 · 0 likes Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear.
Are there stupid questions here? A staff answer, at length Replied, post #124 · Start Here › Welcome · 28 Aug 2025 · 0 likes The Lounge is a real category rather than a dumping ground. The sourcing rule still applies there, which surprises people, but the register is looser and nobody minds a…
Fatigue in the first month: how much is the drug and how much is intake — what changed… Replied, post #52 · Practice › Side effects · 25 Aug 2025 · 0 likes Answering the question post #48 raises rather than the one it answers. Fatigue is a question about a distribution, not about a value, and treating it as a value is what…
Detection wavelength and why 214 nm and 280 nm disagree Replied, post #37 · Analytics › HPLC & UHPLC · 24 Aug 2025 · 28 likes On post #33 — agreed on the reasoning, with one qualification. Where I have landed on detection wavelength, having got it wrong once in public: the direction is clear,…
Immortal time bias in a claims-database study Replied, post #28 · Evidence › Study critique · 23 Aug 2025 · 2 likes The documentation on immortal time bias is better than this thread and I say that as someone who has posted in the thread.
Coming back to: Why quantitation is the hard part, not detection Replied, post #52 · Analytics › Home & field testing · 16 Aug 2025 · 12 likes That is a cleaner way of putting what I was circling around.
Reading a combination trial: attributing effect to components Started this topic · Compounds › Cagrilintide & amylin analogues · 30 Jul 2025 · 32 likes On the subject in the title: Reading a combination trial: attributing effect to components Working notes rather than a conclusion. Collecting what is known about…
Second pass at: What "verified" means on our vendor pages, stated narrowly Replied, post #3 · Sourcing › Vendor reports · 26 Jul 2025 · 5 likes The cost of a submission is worth stating. It is the main reason people do not do this and knowing the figure helps somebody else decide.
A field-by-field walk through a certificate of analysis Replied, post #2 · Analytics › COA interpretation · 13 Jul 2025 · 29 likes On the opening post — agreed on the reasoning, with one qualification. The most useful thing anyone has posted about field-by-field walk through a certificate in this…
Airline travel with a temperature-sensitive injectable — what changed since Replied, post #47 · Devices › Cold chain · 6 Jul 2025 · 26 likes Everything in post #43 holds. The case it does not cover is the one I have. I would rather this thread reach "we do not know" about Airline travel than reach a…
Why fasting instructions for oral semaglutide are not optional advice — does this still… Replied, post #53 · Compounds › Oral incretins · 25 Jun 2025 · 2 likes Dose equivalence between oral and injectable formulations is not a simple conversion and no published factor should be used as one. The two were developed and titrated…
Asking about a compound your prescriber has not heard of Replied, post #71 · Clinical › Prescriber conversations · 20 Jun 2025 · 32 likes This follows post #68 rather than contradicting it. Prescription logistics: confirm whether it will be filled locally, requires mail order, or will be prescribed…
Revisiting: Reading a denial letter as a specification for your appeal Replied, post #14 · Access › Insurance & coverage · 13 Jun 2025 · 6 likes Where an exception process exists separately from an appeal, they are different routes with different criteria and using the wrong one loses time. This is where my…
Half-life, steady state, and accumulation worked through Replied, post #96 · Pharmacology › Pharmacokinetics · 10 Jun 2025 · 4 likes Volume of distribution: the theoretical volume the drug distributes into. For albumin-binding compounds, volume is reduced compared to drugs that do not bind protein.…
Antibiotics and a course of something with delayed emptying Replied, post #58 · Practice › Interactions · 6 Jun 2025 · 4 likes I read post #54 twice before replying, because I had assumed the opposite. SGLT2 inhibitors: frequently co-administered and relevant to renal and cardiovascular…
TB-500 and thymosin beta-4: the fragment versus the protein Replied, post #23 · Compounds › Repair & healing peptides · 26 May 2025 · 0 likes Nothing in this subcategory is medical advice and several members here are describing experiments on themselves. Both of those things should be stated plainly rather…
Coming back to: Sample size calculations, read backwards from the published number Replied, post #30 · Evidence › Trials · 24 May 2025 · 4 likes On post #26 — agreed on the reasoning, with one qualification. Discontinuation handling is the methodological detail that most changes a result and gets the least…
A supplier that answers analytical questions with restated claims Replied, post #81 · Sourcing › Red flags · 22 May 2025 · 0 likes That is a cleaner way of putting what I was circling around.
Pregnancy as an absolute contraindication Replied, post #105 · Safety › Contraindications · 21 May 2025 · 4 likes Understood, and I withdraw the assumption I opened with.
Requesting a translation of an existing page Replied, post #14 · Documentation › Wiki requests · 3 May 2025 · 21 likes Accessibility feedback: if you have trouble accessing or reading a maintained page (screen reader issues, contrast problems, small text) report it. Accessibility…
A page that has drifted out of date and needs a maintainer Replied, post #91 · Documentation › Wiki requests · 18 Apr 2025 · 28 likes Post #88 describes the usual case. This is about the unusual one. Documents that are mostly a worked example age better than documents that are mostly a summary,…
Transit times by route, from a logged dataset — the long version Replied, post #81 · Sourcing › Logistics · 12 Apr 2025 · 2 likes Building on post #80 rather than restating it. Practical note on Transit times: write down what you expect before you look. The number of times I have found what I went…
BPC-157: what the rodent literature actually shows, and what it does not — a second… Replied, post #31 · Compounds › Repair & healing peptides · 6 Apr 2025 · 14 likes Marking my uncertainty on BPC-157 explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past…
Validating a calculator against hand arithmetic — what changed since Replied, post #2 · marked as the solution · Data & Tools › Calculators · 2 Apr 2025 · 11 likes Maintaining a calculator means checking the arithmetic against hand-worked cases at each review, not checking that it still loads.
[2026 update] What the GIP component of tirzepatide is thought to contribute, and how… Replied, post #32 · Compounds › Tirzepatide · 30 Mar 2025 · 0 likes Post #28 describes the usual case. This is about the unusual one. The dual agonism is not a marketing framing — GIP receptor and GLP-1 receptor engagement are both…
Consistent declarations and why they matter more than clever ones Replied, post #157 · Sourcing › Logistics · 10 Mar 2025 · 23 likes The strongest argument against my own position on consistent declarations, stated as well as I can state it, since nobody else has yet.
Coming back to: Recording a dissent on a document rather than suppressing it Replied, post #45 · Documentation › Doc review · 10 Mar 2025 · 0 likes Post #44 is the version of this I will quote in future. One addition. An update on my earlier Recording a dissent post: the pattern held for another six weeks and then…
Counter-ion form: the field almost nobody reports — one year on Replied, post #55 · Analytics › COA interpretation · 6 Mar 2025 · 0 likes Post #51 and I disagree about the size of the effect, not about the direction. Adding a small correction to the Counter-ion form summary above rather than a…
Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Started this topic · Evidence › Journal club · 6 Mar 2025 · 55 likes Posting this under the heading it deserves: Journal club: SURMOUNT-4 and continuation versus withdrawal — a second dataset Everything below is what sits behind that.…
Pharmaceutical compounding rules, summarised from primary sources Replied, post #154 · Sourcing › Regulatory · 6 Mar 2025 · 5 likes Import restrictions vary by compound and by jurisdiction: what is a controlled substance in one place is legal to purchase in another. What you can import for personal…
Second pass at: Manufacturer assistance programmes and their eligibility rules Replied, post #7 · Access › Pricing · 18 Feb 2025 · 0 likes Everything in post #3 holds. The case it does not cover is the one I have. Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance…
An orphaned page with no inbound links Replied, post #5 · Meta › Wiki maintenance · 1 Feb 2025 · 12 likes Post #3 put the caveat in the right place and I want to underline it. I keep a log for orphaned page specifically because my memory of it turned out to be…
Research-use-only status: what it means legally and practically — a second dataset Replied, post #62 · Compounds › Other compounds · 12 Jan 2025 · 0 likes Useful. I had the fact and not the reason, which turns out to be the important half.
[2026 update] New subcategory: rationale and scope Replied, post #121 · Meta › Announcements · 5 Jan 2025 · 11 likes One question about the transition rather than the policy: what happens to topics that are in flight when it takes effect? The announcement is clear about posts and…
Feature request: should a dose-equivalence tool exist at all? Replied, post #6 · Data & Tools › Calculators · 30 Dec 2024 · 32 likes Thank you — that answers what I came here to find out.
Oxidation and deamidation mass shifts, tabulated Replied, post #27 · Analytics › Mass spectrometry · 29 Dec 2024 · 3 likes Mass error in parts per million is (observed minus theoretical) divided by theoretical, times a million. On a high-resolution instrument a low single-digit figure is…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #132 · Practice › Dosing & titration · 23 Dec 2024 · 13 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.…
Building a sensible monitoring schedule with your prescriber Replied, post #21 · Clinical › Bloodwork · 19 Dec 2024 · 0 likes I read post #19 twice before replying, because I had assumed the opposite. Two questions I would want answered before drawing anything from the building a sensible…
Coming back to: When to suspect the method rather than the sample Replied, post #69 · Analytics › Method validation · 13 Dec 2024 · 25 likes An independent laboratory's method being different from the supplier's is not a discrepancy. It becomes one only when the results differ by more than both methods'…
Semaglutide in people without diabetes: what the evidence base looks like Replied, post #4 · Compounds › Semaglutide · 25 Nov 2024 · 11 likes The opening post answers the question as asked. The question underneath it is different. The opalescent appearance in semaglutide solutions is occasionally noted and…
What a stability-indicating method is and how you demonstrate one — one year on Replied, post #71 · Analytics › Method validation · 12 Nov 2024 · 3 likes Linearity across the working range is a routine demonstration and it constrains how far a result can be extrapolated. A method linear from 80 to 120 per cent of nominal…
US compounding rules and how they changed Replied, post #67 · Regional › North America · 11 Nov 2024 · 0 likes Nothing in this subcategory is medical or legal advice, and the clinicians posting here say so on their own account. The right answer here may simply be that it has not…
Hypertension improvement and when medication needs revisiting — a second dataset Replied, post #121 · Clinical › Comorbidities · 28 Oct 2024 · 2 likes Coming back to post #119, because the follow-up matters more than the original answer. Two people in this thread mean different things by Hypertension improvement and…
Pen wastage and its effect on real cost Replied, post #25 · Access › Pricing · 15 Sep 2024 · 6 likes Worth separating two things that post #21 runs together. Compute cost per delivered dose at your dose if you want a number you can act on. Everything else is a…
Progressive overload when the scale is falling — one year on Replied, post #13 · Nutrition & Training › Resistance training · 29 Aug 2024 · 22 likes Marking my place. If it changes for me I will come back and say so.
Correlation in a self-tracked dataset: what it can support Replied, post #21 · Research Methods › Statistics · 20 Aug 2024 · 0 likes Where I part company with post #19, and it is a narrow parting. Adding a reference point for correlation. Mine is a single case, collected without controls, and I am…
Follow-up: Where the four-week escalation interval comes from, and what it is not Replied, post #36 · Practice › Dosing & titration · 30 Jul 2024 · 10 likes I read post #35 twice before replying, because I had assumed the opposite. Holding at a dose that is working is a legitimate position and it is not what the trial…
Reading a meta-analysis you disagree with, fairly Replied, post #7 · Evidence › Meta-analyses · 26 Jul 2024 · 4 likes A meta-analysis of four small trials is not stronger evidence than one adequately powered trial, whatever the summary statistic looks like.
The mass-error checker and its intended scope Replied, post #148 · Data & Tools › Calculators · 23 Jul 2024 · 25 likes Small methodological point on mass-error checker: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
Oral contraceptives and delayed emptying: what the data shows Replied, post #10 · Practice › Interactions · 6 Jul 2024 · 0 likes The bit of oral contraceptives and delayed emptying that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the…